Now showing items 1-2 of 2

    • Modelling kidney disease with CRISPR-mutant kidney organoids derived from human pluripotent epiblast spheroids 

      Freedman, Benjamin S.; Brooks, Craig R.; Lam, Albert Q.; Fu, Hongxia; Morizane, Ryuji; Agrawal, Vishesh; Saad, Abdelaziz F.; Li, Michelle K.; Hughes, Michael R.; Werff, Ryan Vander; Peters, Derek T.; Lu, Junjie; Baccei, Anna; Siedlecki, Andrew M.; Valerius, M. Todd; Musunuru, Kiran; McNagny, Kelly M.; Steinman, Theodore I.; Zhou, Jing; Lerou, Paul H.; Bonventre, Joseph V. (Nature Pub. Group, 2015)
      Human-pluripotent-stem-cell-derived kidney cells (hPSC-KCs) have important potential for disease modelling and regeneration. Whether the hPSC-KCs can reconstitute tissue-specific phenotypes is currently unknown. Here we ...
    • Multi-Scale Imaging and Informatics Pipeline for In Situ Pluripotent Stem Cell Analysis 

      Gorman, Bryan R.; Lu, Junjie; Baccei, Anna; Lowry, Nathan C.; Purvis, Jeremy E.; Mangoubi, Rami S.; Lerou, Paul H. (Public Library of Science, 2014)
      Human pluripotent stem (hPS) cells are a potential source of cells for medical therapy and an ideal system to study fate decisions in early development. However, hPS cells cultured in vitro exhibit a high degree of ...