Browsing HMS Scholarly Articles by Author "Qi, Lin"

Now showing items 1-2 of 2

    • The regulation of N-terminal Huntingtin (Htt552) accumulation by Beclin1 

      Wu, Jun-chao; Lin, Fang; Qi, Lin; Wang, Yan; Kegel, Kimberly B; Yoder, Jennifer; Difiglia, Marian; Qin, Zheng-hong (Nature Publishing Group, 2012)
      Aim: Huntingtin protein (Htt) was a neuropathological hallmark in human Huntington's Disease. The study aimed to investigate whether the macroautophagy regulator, Beclin1, was involved in the degradation of Htt. Methods: ...

    • The Role of Chaperone-Mediated Autophagy in Huntingtin Degradation 

      Qi, Lin; Lin, Fang; Zhang, Xing-Ding; Wu, Jun-Chao; Wang, Jin; DiFiglia, Marian; Qin, Zheng-Hong (Public Library of Science, 2012)
      Huntington Disease (HD) is caused by an abnormal expansion of polyQ tract in the protein named huntingtin (Htt). HD pathology is featured by accumulation and aggregation of mutant Htt in striatal and cortical neurons. ...