Browsing HMS Scholarly Articles by Author "Kwon, Douglas S."

Now showing items 1-3 of 3

    • Capturing sequence diversity in metagenomes with comprehensive and scalable probe design 

      Metsky, Hayden C.; Siddle, Katherine J.; Gladden-Young, Adrianne; Qu, James; Yang, David K.; Brehio, Patrick; Goldfarb, Andrew; Piantadosi, Anne; Wohl, Shirlee; Carter, Amber; Lin, Aaron E.; Barnes, Kayla G.; Tully, Damien C.; Corleis, Bjӧrn; Hennigan, Scott; Barbosa-Lima, Giselle; Vieira, Yasmine R.; Paul, Lauren M.; Tan, Amanda L.; Garcia, Kimberly F.; Parham, Leda A.; Odia, Ikponmwosa; Eromon, Philomena; Folarin, Onikepe A.; Goba, Augustine; Simon-Lorière, Etienne; Hensley, Lisa; Balmaseda, Angel; Harris, Eva; Kwon, Douglas S.; Allen, Todd M.; Runstadler, Jonathan A.; Smole, Sandra; Bozza, Fernando A.; Souza, Thiago M. L.; Isern, Sharon; Michael, Scott F.; Lorenzana, Ivette; Gehrke, Lee; Bosch, Irene; Ebel, Gregory; Grant, Donald S.; Happi, Christian T.; Park, Daniel J.; Gnirke, Andreas; Sabeti, Pardis; Matranga, Christian B. (Springer Science and Business Media LLC, 2019-02)
      Metagenomic sequencing has the potential to transform microbial detection and characterization, but new tools are needed to improve its sensitivity. Here we present CATCH, a computational method to enhance nucleic-acid ...

    • Electron Tomography of HIV-1 Infection in Gut-Associated Lymphoid Tissue 

      Ladinsky, Mark S.; Kieffer, Collin; Olson, Gregory; Deruaz, Maud; Vrbanac, Vladimir; Tager, Andrew M.; Kwon, Douglas S.; Bjorkman, Pamela J. (Public Library of Science, 2014)
      Critical aspects of HIV-1 infection occur in mucosal tissues, particularly in the gut, which contains large numbers of HIV-1 target cells that are depleted early in infection. We used electron tomography (ET) to image HIV-1 ...

    • IL-21 induces antiviral microRNA-29 in CD4 T cells to limit HIV-1 infection 

      Adoro, Stanley; Cubillos-Ruiz, Juan R.; Chen, Xi; Deruaz, Maud; Vrbanac, Vladimir; Song, Minkyung; Park, Suna; Murooka, Thomas T.; Dudek, Timothy E.; Luster, Andrew D.; Tager, Andrew M.; Streeck, Hendrik; Bowman, Brittany; Walker, Bruce D.; Kwon, Douglas S.; Lazarevic, Vanja; Glimcher, Laurie H. (Nature Pub. Group, 2015)
      Initial events after exposure determine HIV-1 disease progression, underscoring a critical need to understand host mechanisms that interfere with initial viral replication. Although associated with chronic HIV-1 control, ...