Now showing items 1-2 of 2

    • Dissecting genetic requirements of human breast tumorigenesis in a tissue transgenic model of human breast cancer in mice 

      Wu, Min; Jung, Lina; Cooper, Adrian B.; Fleet, Christina; Chen, Lihao; Breault, Lyne; Clark, Kimberly; Cai, Zuhua; Vincent, Sylvie; Bottega, Steve; Shen, Qiong; Richardson, Andrea; Bosenburg, Marcus; Naber, Stephen P.; DePinho, Ronald A.; Kuperwasser, Charlotte; Robinson, Murray O. (National Academy of Sciences, 2009)
      Breast cancer development is a complex pathobiological process involving sequential genetic alterations in normal epithelial cells that results in uncontrolled growth in a permissive microenvironment. Accordingly, ...
    • Haploinsufficiency for BRCA1 leads to cell-type-specific genomic instability and premature senescence 

      Sedic, Maja; Skibinski, Adam; Brown, Nelson; Gallardo, Mercedes; Mulligan, Peter; Martinez, Paula; Keller, Patricia J.; Glover, Eugene; Richardson, Andrea L.; Cowan, Janet; Toland, Amanda E.; Ravichandran, Krithika; Riethman, Harold; Naber, Stephen P.; Näär, Anders M.; Blasco, Maria A.; Hinds, Philip W.; Kuperwasser, Charlotte (Nature Pub. Group, 2015)
      Although BRCA1 function is essential for maintaining genomic integrity in all cell types, it is unclear why increased risk of cancer in individuals harbouring deleterious mutations in BRCA1 is restricted to only a select ...