Now showing items 21-23 of 23

    • SiteOut: An Online Tool to Design Binding Site-Free DNA Sequences 

      Estrada, Javier; Ruiz-Herrero, Teresa; Scholes, Clarissa; Wunderlich, Zeba; DePace, Angela H. (Public Library of Science, 2016)
      DNA-binding proteins control many fundamental biological processes such as transcription, recombination and replication. A major goal is to decipher the role that DNA sequence plays in orchestrating the binding and activity ...
    • Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes 

      Utheim, Tor Paaske; Islam, Rakibul; Fostad, Ida G.; Eidet, Jon R.; Sehic, Amer; Olstad, Ole K.; Dartt, Darlene A.; Messelt, Edward B.; Griffith, May; Pasovic, Lara (Public Library of Science, 2016)
      Purpose Storage of cultured human oral keratinocytes (HOK) allows for transportation of cultured transplants to eye clinics worldwide. In a previous study, one-week storage of cultured HOK was found to be superior with ...
    • Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data 

      Shi, Jianxin; Park, Ju-Hyun; Duan, Jubao; Berndt, Sonja T.; Moy, Winton; Yu, Kai; Song, Lei; Wheeler, William; Hua, Xing; Silverman, Debra; Garcia-Closas, Montserrat; Hsiung, Chao Agnes; Figueroa, Jonine D.; Cortessis, Victoria K.; Malats, Núria; Karagas, Margaret R.; Vineis, Paolo; Chang, I-Shou; Lin, Dongxin; Zhou, Baosen; Seow, Adeline; Matsuo, Keitaro; Hong, Yun-Chul; Caporaso, Neil E.; Wolpin, Brian; Jacobs, Eric; Petersen, Gloria M.; Klein, Alison P.; Li, Donghui; Risch, Harvey; Sanders, Alan R.; Hsu, Li; Schoen, Robert E.; Brenner, Hermann; Stolzenberg-Solomon, Rachael; Gejman, Pablo; Lan, Qing; Rothman, Nathaniel; Amundadottir, Laufey T.; Landi, Maria Teresa; Levinson, Douglas F.; Chanock, Stephen J.; Chatterjee, Nilanjan (Public Library of Science, 2016)
      Recent heritability analyses have indicated that genome-wide association studies (GWAS) have the potential to improve genetic risk prediction for complex diseases based on polygenic risk score (PRS), a simple modelling ...