Browsing HMS Scholarly Articles by Keyword "DNA-binding proteins"
Now showing items 21-23 of 23
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SiteOut: An Online Tool to Design Binding Site-Free DNA Sequences
(Public Library of Science, 2016)DNA-binding proteins control many fundamental biological processes such as transcription, recombination and replication. A major goal is to decipher the role that DNA sequence plays in orchestrating the binding and activity ... -
Storage Temperature Alters the Expression of Differentiation-Related Genes in Cultured Oral Keratinocytes
(Public Library of Science, 2016)Purpose Storage of cultured human oral keratinocytes (HOK) allows for transportation of cultured transplants to eye clinics worldwide. In a previous study, one-week storage of cultured HOK was found to be superior with ... -
Winner's Curse Correction and Variable Thresholding Improve Performance of Polygenic Risk Modeling Based on Genome-Wide Association Study Summary-Level Data
(Public Library of Science, 2016)Recent heritability analyses have indicated that genome-wide association studies (GWAS) have the potential to improve genetic risk prediction for complex diseases based on polygenic risk score (PRS), a simple modelling ...