Browsing HMS Scholarly Articles by Keyword "T cells"
Now showing items 21-26 of 26
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Regulation of T Cell Differentiation and Function by EZH2
(Frontiers Media S.A., 2016)The enhancer of zeste homolog 2 (EZH2), one of the polycomb-group proteins, is the catalytic subunit of Polycomb-repressive complex 2 (PRC2) and induces the trimethylation of the histone H3 lysine 27 (H3K27me3) promoting ... -
A Subset of Latency-Reversing Agents Expose HIV-Infected Resting CD4+ T-Cells to Recognition by Cytotoxic T-Lymphocytes
(Public Library of Science, 2016)Resting CD4+ T-cells harboring inducible HIV proviruses are a critical reservoir in antiretroviral therapy (ART)-treated subjects. These cells express little to no viral protein, and thus neither die by viral cytopathic ... -
T Cell Costimulatory and Coinhibitory Pathways in Vascular Inflammatory Diseases
(Frontiers Research Foundation, 2012)A broad array of evidence indicates that T lymphocytes make significant contributions to vascular inflammation in the setting of atherosclerotic disease, hypertension, autoimmune vasculitis, and other disorders. Experimental ... -
Targeting cancer stem cells with p53 modulators
(Impact Journals LLC, 2016)Cancer stem cells (CSC) typically over-express aldehyde dehydrogenase (ALDH). Thus, ALDHbright tumor cells represent targets for developing novel cancer prevention/treatment interventions. Loss of p53 function is a common ... -
TIM3 Mediates T Cell Exhaustion during Mycobacterium tuberculosis Infection
(Public Library of Science, 2016)While T cell immunity initially limits Mycobacterium tuberculosis infection, why T cell immunity fails to sterilize the infection and allows recrudescence is not clear. One hypothesis is that T cell exhaustion impairs ... -
Towards the introduction of the ‘Immunoscore’ in the classification of malignant tumours
(John Wiley & Sons, Ltd, 2013)The American Joint Committee on Cancer/Union Internationale Contre le Cancer (AJCC/UICC) TNM staging system provides the most reliable guidelines for the routine prognostication and treatment of colorectal carcinoma. This ...