Browsing HMS Scholarly Articles by Keyword "cancer"
Now showing items 21-40 of 72
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Extracellular vesicles, tissue factor, cancer and thrombosis – discussion themes of the ISEV 2014 Educational Day
(Co-Action Publishing, 2015)Although the association between cancer and venous thromboembolism (VTE) has long been known, the mechanisms are poorly understood. Circulating tissue factor–bearing extracellular vesicles have been proposed as a possible ... -
Factors Predicting Survival in Patients with Proximal Gastric Carcinoma Involving the Esophagus
(Baishideng Publishing Group Co., Limited (formerly WJG Press), 2012)AIM: To investigate the clinicopathologic features which predict surgical overall survival in patients with proximal gastric carcinoma involving the esophagus (PGCE). METHODS: Electronic pathology database established ... -
Focus on Extracellular Vesicles: New Frontiers of Cell-to-Cell Communication in Cancer
(MDPI, 2016)Extracellular Vesicles (EVs) have received considerable attention in recent years, both as mediators of intercellular communication pathways that lead to tumor progression, and as potential sources for discovery of novel ... -
Functional Identification of Api5 as a Suppressor of E2F-Dependent Apoptosis In Vivo
(Public Library of Science, 2006)Retinoblastoma protein and E2-promoter binding factor (E2F) family members are important regulators of G1-S phase progression. Deregulated E2F also sensitizes cells to apoptosis, but this aspect of E2F function is poorly ... -
Gastric cardiac carcinomas involving the esophagus are more adequately staged as gastric cancers by the 7th edition of the American Joint Commission on Cancer Staging System
(Springer Nature, 2010)Background: The genetics of advanced biliary tract cancers (BTC), which encompass intra- and extra-hepatic cholangiocarcinomas as well as gallbladder carcinomas, are heterogeneous and remain to be fully defined. Methods: ... -
Genome-Wide Analysis of ETS-Family DNA-Binding In Vitro and In Vivo
(Nature Publishing Group, 2010)Members of the large ETS family of transcription factors (TFs) have highly similar DNA-binding domains (DBDs)—yet they have diverse functions and activities in physiology and oncogenesis. Some differences in DNA-binding ... -
High-throughput approaches to discover novel immunomodulatory agents for cancer
(Landes Bioscience, 2012)The clinical success of immunomodulatory thalidomide derivatives has renewed the general interest in immunomodulatory anticancer compounds and prompted us to develop a high-throughput system to quantify immune effector-cell ... -
Identification of acetylation-dependent regulatory mechanisms that govern the oncogenic functions of Skp2
(Impact Journals LLC, 2012)The Skp2 (S-phase kinase associated protein 2) oncoprotein is often highly expressed in various types of human cancers. However, the mechanistic basis of its oncogenic function, as well as the upstream regulatory pathway(s) ... -
IKK\(\beta\) Regulates Essential Functions of the Vascular Endothelium Through Kinase-Dependent and -Independent Pathways
(Nature Publishing Group, 2011)Vascular endothelium provides a selective barrier between the blood and tissues, participates in wound healing and angiogenesis, and regulates tissue recruitment of inflammatory cells. Nuclear factor (NF)- \(\kappa\)B ... -
Impact of Circulating Cholesterol Levels on Growth and Intratumoral Androgen Concentration of Prostate Tumors
(Public Library of Science, 2012)Prostate cancer (PCa) is the second most common cancer in men. Androgen deprivation therapy (ADT) leads to tumor involution and reduction of tumor burden. However, tumors eventually reemerge that have overcome the absence ... -
The Impact of Economic Recession on the Incidence and Treatment of Cancer
(Ivyspring International Publisher, 2015)Purpose: The impact of economic recessions on the incidence and treatment of cancer is unknown. We test the hypothesis that cancer incidence and treatment rates decrease during a recession, and that this relationship is ... -
Influence of Patients' Preferences and Treatment Site on Cancer Patients' End-of-Life Care
(Wiley-Blackwell, 2010)BACKGROUND: Research suggests that patients' end-of-life (EOL) care is determined primarily by the medical resources available, and not by patient preferences. The authors examined whether patients' desire for life-extending ... -
Injection of Syngeneic Murine Melanoma Cells to Determine Their Metastatic Potential in the Lungs
(MyJove Corporation, 2016)Approximately 90% of human cancer deaths are linked to metastasis. Despite the prevalence and relative harm of metastasis, therapeutics for treatment or prevention are lacking. We report a method for the establishment of ... -
Integration of Architectural and Cytologic Driven Image Algorithms for Prostate Adenocarcinoma Identification
(IOS Press, 2012)Introduction:: The advent of digital slides offers new opportunities within the practice of pathology such as the use of image analysis techniques to facilitate computer aided diagnosis (CAD) solutions. Use of CAD holds ... -
The International Cancer Expert Corps: A Unique Approach for Sustainable Cancer Care in Low and Lower-Middle Income Countries
(Frontiers Media S.A., 2014)The growing burden of non-communicable diseases including cancer in low- and lower-middle income countries (LMICs) and in geographic-access limited settings within resource-rich countries requires effective and sustainable ... -
Intracellular activation of EGFR by fatty acid synthase dependent palmitoylation
(Impact Journals LLC, 2015)Epidermal growth factor receptor (EGFR) is an oncogenic receptor tyrosine kinase. Canonically, the tyrosine kinase activity of EGFR is regulated by its extracellular ligands. However, ligand-independent activation of EGFR ... -
Junk DNA and the long non-coding RNA twist in cancer genetics
(2015)The central dogma of molecular biology states that the flow of genetic information moves from DNA to RNA to protein. However, in the last decade this dogma has been challenged by new findings on non-coding RNAs (ncRNAs) ... -
The landscape of metastatic progression patterns across major human cancers
(Impact Journals LLC, 2015)The majority of patients with solid malignancies die from metastatic burden. However, our current understanding of the mechanisms and resulting patterns of dissemination is limited. Here, we analyzed patterns of metastatic ... -
Longitudinal confocal microscopy imaging of solid tumor destruction following adoptive T cell transfer
(Landes Bioscience, 2013)A fluorescence-based, high-resolution imaging approach was used to visualize longitudinally the cellular events unfolding during T cell-mediated tumor destruction. The dynamic interplay of T cells, cancer cells, cancer ... -
Mechanisms of Cancer Induction by Tobacco-Specific NNK and NNN
(MDPI, 2014)Tobacco use is a major public health problem worldwide. Tobacco-related cancers cause millions of deaths annually. Although several tobacco agents play a role in the development of tumors, the potent effects of ...