Browsing HMS Scholarly Articles by Title

Now showing items 10310-10329 of 17922

    • Membrane Binding of MinE Allows for a Comprehensive Description of Min-Protein Pattern Formation 

      Bonny, Mike; Fischer-Friedrich, Elisabeth; Loose, Martin; Schwille, Petra; Kruse, Karsten (Public Library of Science, 2013)
      The rod-shaped bacterium Escherichia coli selects the cell center as site of division with the help of the proteins MinC, MinD, and MinE. This protein system collectively oscillates between the two cell poles by alternately ...

    • Membrane dynamics of dividing cells imaged by lattice light-sheet microscopy 

      Aguet, François; Upadhyayula, Srigokul; Gaudin, Raphaël; Chou, Yi-ying; Cocucci, Emanuele; He, Kangmin; Chen, Bi-Chang; Mosaliganti, Kishore; Pasham, Mithun; Skillern, Wesley; Legant, Wesley R.; Liu, Tsung-Li; Findlay, Greg; Marino, Eric; Danuser, Gaudenz; Megason, Sean; Betzig, Eric; Kirchhausen, Tom (The American Society for Cell Biology, 2016)
      Membrane remodeling is an essential part of transferring components to and from the cell surface and membrane-bound organelles and for changes in cell shape, which are particularly critical during cell division. Earlier ...

    • Membrane fission by dynamin: what we know and what we need to know 

      Antonny, Bruno; Burd, Christopher; De Camilli, Pietro; Chen, Elizabeth; Daumke, Oliver; Faelber, Katja; Ford, Marijn; Frolov, Vadim A; Frost, Adam; Hinshaw, Jenny E; Kirchhausen, Tom; Kozlov, Michael M; Lenz, Martin; Low, Harry H; McMahon, Harvey; Merrifield, Christien; Pollard, Thomas D; Robinson, Phillip J; Roux, Aurélien; Schmid, Sandra (John Wiley and Sons Inc., 2016)
      Abstract The large GTPase dynamin is the first protein shown to catalyze membrane fission. Dynamin and its related proteins are essential to many cell functions, from endocytosis to organelle division and fusion, and it ...

    • Membrane guanylyl cyclase complexes shape the photoresponses of retinal rods and cones 

      Wen, Xiao-Hong; Dizhoor, Alexander M; Makino, Clint L (Frontiers Media S.A., 2014)
      In vertebrate rods and cones, photon capture by rhodopsin leads to the destruction of cyclic GMP (cGMP) and the subsequent closure of cyclic nucleotide gated ion channels in the outer segment plasma membrane. Replenishment ...

    • Membrane-Assisted Growth of DNA Origami Nanostructure Arrays 

      Kocabey, Samet; Kempter, Susanne; List, Jonathan; Xing, Yongzheng; Bae, Wooli; Schiffels, Daniel; Shih, William M.; Simmel, Friedrich C.; Liedl, Tim (American Chemical Society, 2015)
      Biological membranes fulfill many important tasks within living organisms. In addition to separating cellular volumes, membranes confine the space available to membrane-associated proteins to two dimensions (2D), which ...

    • Membrane-bound and soluble Fas ligands have opposite functions in photoreceptor cell death following separation from the retinal pigment epithelium 

      Matsumoto, H; Murakami, Y; Kataoka, K; Notomi, S; Mantopoulos, D; Trichonas, G; Miller, J W; Gregory, M S; Ksander, B R; Marshak-Rothstein, A; Vavvas, D G (Nature Publishing Group, 2015)
      Fas ligand (FasL) triggers apoptosis of Fas-positive cells, and previous reports described FasL-induced cell death of Fas-positive photoreceptors following a retinal detachment. However, as FasL exists in membrane-bound ...

    • Membrane-To-Nucleus Signaling Links Insulin-Like Growth Factor-1- and Stem Cell Factor-Activated Pathways 

      Hayashi, Yujiro; Asuzu, David T.; Gibbons, Simon J.; Aarsvold, Kirsten H.; Bardsley, Michael R.; Lomberk, Gwen A.; Mathison, Angela J.; Kendrick, Michael L.; Shen, K. Robert; Taguchi, Takahiro; Gupta, Anu; Rubin, Brian P.; Fletcher, Jonathan A.; Farrugia, Gianrico; Urrutia, Raul A.; Ordog, Tamas (Public Library of Science, 2013)
      Stem cell factor (mouse: Kitl, human: KITLG) and insulin-like growth factor-1 (IGF1), acting via KIT and IGF1 receptor (IGF1R), respectively, are critical for the development and integrity of several tissues. Autocrine/paracrine ...

    • Memory and Emotions for the September 11, 2001, Terrorist Attacks in Patients With Alzheimer's Disease, Patients With Mild Cognitive Impairment, and Healthy Older Adults. 

      Budson, Andrew E.; Daffner, Kirk R.; Schacter, Daniel L.; Simons, Jon; `Sullivan, Alison; Beier, Jonathan; Solomon, Paul; Scinto, Leonard (American Psychological Association (APA), 2004)
      National traumatic events can produce extremely vivid memories. Using a questionnaire administered during telephone interviews, the authors investigated emotional responses to, and memory for. the September 11, 2001, ...

    • Memory and Modularity in Cell-Fate Decision Making 

      Norman, Thomas M.; Lord, Nathan D.; Paulsson, Johan; Losick, Richard (2014)
      Genetically identical cells sharing an environment can display markedly different phenotypes. It is often unclear how much of this variation derives from chance, external signals, or attempts by individual cells to exert ...

    • Memory B Cell and Other Immune Responses in Children Receiving Two Doses of an Oral Killed Cholera Vaccine Compared to Responses following Natural Cholera Infection in Bangladesh 

      Leung, Daniel; Rahman, Mohammad Arif; Mohasin, M.; Patel, Sweta; Aktar, Amena; Khanam, Farhana; Uddin, Taher; Riyadh, M. Asrafuzzaman; Saha, Amit; Alam, Mohammad Murshid; Chowdhury, Fahima; Khan, Ashraful Islam; Charles, Richelle; LaRocque, Regina; Harris, Jason; Calderwood, Stephen; Qadri, Firdausi; Ryan, Edward (American Society for Microbiology, 2012)
      Current oral cholera vaccines induce lower protective efficacy and shorter duration of protection against cholera than wild-type infection provides, and this difference is most pronounced in young children. Despite this, ...

    • Memory B Cell Responses to Vibrio cholerae O1 Lipopolysaccharide Are Associated with Protection against Infection from Household Contacts of Patients with Cholera in Bangladesh 

      Patel, Sweta M.; Rahman, Mohammad Arif; Mohasin, M.; Riyadh, M. Asrafuzzaman; Leung, Daniel T.; Alam, Mohammad Murshid; Chowdhury, Fahima; Khan, Ashraful I.; Weil, Ana A.; Aktar, Amena; Nazim, Mohammad; LaRocque, Regina C.; Ryan, Edward T.; Calderwood, Stephen B.; Qadri, Firdausi; Harris, Jason B. (American Society for Microbiology, 2012)
      Vibrio cholerae O1 causes cholera, a dehydrating diarrheal disease. We have previously shown that V. cholerae-specific memory B cell responses develop after cholera infection, and we hypothesize that these mediate long-term ...

    • Memory for Semantically Related and Unrelated Declarative Information: The Benefit of Sleep, the Cost of Wake 

      Payne, Jessica D.; Tucker, Matthew; Ellenbogen, Jeffrey; Wamsley, Erin; Walker, Matthew P.; Schacter, Daniel L.; Stickgold, Robert A. (Public Library of Science, 2012)
      Numerous studies have examined sleep's influence on a range of hippocampus-dependent declarative memory tasks, from text learning to spatial navigation. In this study, we examined the impact of sleep, wake, and time-of-day ...

    • Memory T-Cell Responses to Vibrio cholerae O1 Infection 

      Weil, Ana A.; Arifuzzaman, Mohammad; Bhuiyan, Taufiqur R.; LaRocque, Regina C.; Harris, Aaron M.; Kendall, Emily A.; Hossain, Azim; Tarique, Abdullah A.; Sheikh, Alaullah; Chowdhury, Fahima; Khan, Ashraful I.; Murshed, Farhan; Parker, Kenneth C.; Banerjee, Kalyan K.; Ryan, Edward T.; Harris, Jason B.; Qadri, Firdausi; Calderwood, Stephen B. (American Society for Microbiology, 2009)
      Vibrio cholerae O1 can cause diarrheal disease that may be life-threatening without treatment. Natural infection results in long-lasting protective immunity, but the role of T cells in this immune response has not been ...

    • MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis 

      Oudin, Madeleine J.; Miller, Miles A.; Klazen, Joelle A. Z.; Kosciuk, Tatsiana; Lussiez, Alisha; Hughes, Shannon K.; Tadros, Jenny; Bear, James E.; Lauffenburger, Douglas A.; Gertler, Frank B. (The American Society for Cell Biology, 2016)
      Directed cell migration, a key process in metastasis, arises from the combined influence of multiple processes, including chemotaxis—the directional movement of cells to soluble cues—and haptotaxis—the migration of cells ...

    • Mendelian randomisation analysis strongly implicates adiposity with risk of developing colorectal cancer 

      Jarvis, David; Mitchell, Jonathan S; Law, Philip J; Palin, Kimmo; Tuupanen, Sari; Gylfe, Alexandra; Hänninen, Ulrika A; Cajuso, Tatiana; Tanskanen, Tomas; Kondelin, Johanna; Kaasinen, Eevi; Sarin, Antti-Pekka; Kaprio, Jaakko; Eriksson, Johan G; Rissanen, Harri; Knekt, Paul; Pukkala, Eero; Jousilahti, Pekka; Salomaa, Veikko; Ripatti, Samuli; Palotie, Aarno; Järvinen, Heikki; Renkonen-Sinisalo, Laura; Lepistö, Anna; Böhm, Jan; Meklin, Jukka-Pekka; Al-Tassan, Nada A; Palles, Claire; Martin, Lynn; Barclay, Ella; Farrington, Susan M; Timofeeva, Maria N; Meyer, Brian F; Wakil, Salma M; Campbell, Harry; Smith, Christopher G; Idziaszczyk, Shelley; Maughan, Timothy S; Kaplan, Richard; Kerr, Rachel; Kerr, David; Buchanan, Daniel D; Win, Aung K; Hopper, John L; Jenkins, Mark A; Lindor, Noralane M; Newcomb, Polly A; Gallinger, Steve; Conti, David; Schumacher, Fred; Casey, Graham; Taipale, Jussi; Aaltonen, Lauri A; Cheadle, Jeremy P; Dunlop, Malcolm G; Tomlinson, Ian P; Houlston, Richard S (Nature Publishing Group, 2016)
      Background: Observational studies have associated adiposity with an increased risk of colorectal cancer (CRC). However, such studies do not establish a causal relationship. To minimise bias from confounding we performed a ...

    • A Mendelian randomization study of the effect of type-2 diabetes on coronary heart disease 

      Ahmad, Omar S.; Morris, John A.; Mujammami, Muhammad; Forgetta, Vincenzo; Leong, Aaron; Li, Rui; Turgeon, Maxime; Greenwood, Celia M.T.; Thanassoulis, George; Meigs, James B.; Sladek, Robert; Richards, J. Brent (Nature Pub. Group, 2015)
      In observational studies, type-2 diabetes (T2D) is associated with an increased risk of coronary heart disease (CHD), yet interventional trials have shown no clear effect of glucose-lowering on CHD. Confounding may have ...

    • Meningioma Genomics: Diagnostic, Prognostic, and Therapeutic Applications 

      Bi, Wenya Linda; Zhang, Michael; Wu, Winona W.; Mei, Yu; Dunn, Ian F. (Frontiers Media S.A., 2016)
      There has been a recent revolution in our understanding of the genetic factors that drive meningioma, punctuating an equilibrium that has existed since Cushing’s germinal studies nearly a century ago. A growing appreciation ...

    • A Meningococcal Outer Membrane Vesicle Vaccine Incorporating Genetically Attenuated Endotoxin Dissociates Inflammation from Immunogenicity 

      Dowling, David J.; Sanders, Holly; Cheng, Wing Ki; Joshi, Sweta; Brightman, Spencer; Bergelson, Ilana; Pietrasanta, Carlo; van Haren, Simon D.; van Amsterdam, Sandra; Fernandez, Jeffrey; van den Dobbelsteen, Germie P. J. M.; Levy, Ofer (Frontiers Media S.A., 2016)
      Background: Group B Neisseria meningitidis, an endotoxin-producing Gram-negative bacterium, causes the highest incidence of group B meningococcus (MenB) disease in the first year of life. The Bexsero vaccine is indicated ...

    • Meniscus Injuries Alter the Kinematics of Knees With Anterior Cruciate Ligament Deficiency 

      Hosseini, Ali; Li, Jing-Sheng; Gill, Thomas J.; Li, Guoan (SAGE Publications, 2014)
      Background: Most knee joint biomechanics studies have involved knees with an isolated anterior cruciate ligament (ACL) injury. However, a large portion of patients with injured ACLs have accompanied meniscus tearing. In ...

    • Menstrual pain and epithelial ovarian cancer risk 

      Babic, Ana; Cramer, Daniel William; Titus, Linda J.; Tworoger, Shelley Slate; Terry, Kathryn Lynne (Springer Science + Business Media, 2014)
      Purpose Menstrual pain is associated with increased production of inflammatory molecules, such as prostaglandins. Inflammation is involved in pathogenesis of several cancers, including ovarian cancer. In this study we ...