Browsing HMS Scholarly Articles by Title

Now showing items 10436-10455 of 17922

    • Methodological Framework for World Health Organization Estimates of the Global Burden of Foodborne Disease 

      Devleesschauwer, Brecht; Haagsma, Juanita A.; Angulo, Frederick J.; Bellinger, David C.; Cole, Dana; Döpfer, Dörte; Fazil, Aamir; Fèvre, Eric M.; Gibb, Herman J.; Hald, Tine; Kirk, Martyn D.; Lake, Robin J.; Maertens de Noordhout, Charline; Mathers, Colin D.; McDonald, Scott A.; Pires, Sara M.; Speybroeck, Niko; Thomas, M. Kate; Torgerson, Paul R.; Wu, Felicia; Havelaar, Arie H.; Praet, Nicolas (Public Library of Science, 2015)
      Background: The Foodborne Disease Burden Epidemiology Reference Group (FERG) was established in 2007 by the World Health Organization to estimate the global burden of foodborne diseases (FBDs). This paper describes the ...

    • Methodology for developing quality indicators for the care of older people in the Emergency Department 

      Martin-Khan, Melinda; Burkett, Ellen; Schnitker, Linda; Jones, Richard N; Gray, Leonard C (BioMed Central, 2013)
      Background: Compared with younger people, older people have a higher risk of adverse health outcomes when presenting to emergency departments. As the population ages, older people will make up an increasing proportion of ...

    • Methodology for the Development of a Taxonomy and Toolkit to Evaluate Health-related Habits and Lifestyle (eVITAL) 

      Alonso, Federico; Salvador-Carulla, Luis; Walsh, Carolyn Ayer; The eVITAL group (BioMed Central, 2010)
      Background: Chronic diseases cause an ever-increasing percentage of morbidity and mortality, but many have modifiable risk factors. Many behaviors that predispose or protect an individual to chronic disease are interrelated, ...

    • Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization 

      Link, AJ; Phillips, D; Church, George (American Society for Microbiology, 1997-10)
      We have developed a new system of chromosomal mutagenesis in order to study the functions of uncharacterized open reading frames (ORFs) in wild-type Escherichia coli. Because of the operon structure of this organism, ...

    • Methods Guide for Authors of Systematic Reviews of Medical Tests: A Collaboration Between the Agency for Healthcare Research and Quality (AHRQ) and the Journal of General Internal Medicine 

      Smetana, Gerald William; Umscheid, Craig A.; Chang, Stephanie; Matchar, David B. (Springer-Verlag, 2012)

    • Methods of high integrity RNA extraction from cell/agarose construct 

      Ogura, Takahiro; Tsuchiya, Akihiro; Minas, Tom; Mizuno, Shuichi (BioMed Central, 2015)
      Background: Agarose hydrogels are widely used for three-dimensional cell scaffolding in tissue engineering and cell biology. Recently, molecular profiles have been obtained with extraction of a minimal volume of RNA using ...

    • Methods of Suicide: International Suicide Patters Derived From the WHO Mortality Database 

      Ajdacic-Gross, Vladeta; Weiss, Mitchell; Ring, Mariann; Hepp, Urs; Bopp, Matthias; Gutzwiller, Felix; Rössler, Wulf (World Health Organization, 2008-09)
      Objective Accurate information about preferred suicide methods is important for devising strategies and programmes for suicide prevention. Our knowledge of the methods used and their variation across countries and world ...

    • Methods to Develop an Electronic Medical Record Phenotype Algorithm to Compare the Risk of Coronary Artery Disease across 3 Chronic Disease Cohorts 

      Liao, Katherine P.; Ananthakrishnan, Ashwin N.; Kumar, Vishesh; Xia, Zongqi; Cagan, Andrew; Gainer, Vivian S.; Goryachev, Sergey; Chen, Pei; Savova, Guergana K.; Agniel, Denis; Churchill, Susanne; Lee, Jaeyoung; Murphy, Shawn N.; Plenge, Robert M.; Szolovits, Peter; Kohane, Isaac; Shaw, Stanley Y.; Karlson, Elizabeth W.; Cai, Tianxi (Public Library of Science, 2015)
      Background: Typically, algorithms to classify phenotypes using electronic medical record (EMR) data were developed to perform well in a specific patient population. There is increasing interest in analyses which can allow ...

    • Methylation by Set9 Modulates FoxO3 Stability and Transcriptional Activity 

      Calnan, Daniel R.; Webb, Ashley E.; White, Jamie L.; Stowe, Timothy R.; Goswami, Tapasree; Shi, Xiaobing; Espejo, Alexsandra; Bedford, Mark T.; Gozani, Or; Brunet, Anne; Gygi, Steven P. (Impact Journals LLC, 2012)
      The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme ...

    • Methylation-dependent and -independent roles of EZH2 synergize in CDCA8 activation in prostate cancer 

      Yi, Yang; Li, Yanqiang; Li, Chao; Wu, Longxiang; Zhao, Dongyu; Li, Fuxi; Fazli, Ladan; Wang, Rui; Wang, Long; Dong, Xuesen; Zhao, Wei; Chen, Kaifu; Cao, Qi (Springer Science and Business Media LLC, 2022-01-29)
      Cell division cycle associated 8 (CDCA8) is a component of chromosomal passenger complex (CPC) that participates in mitotic regulation. Although cancer-related CDCA8 hyperactivation has been widely observed, its molecular ...

    • Methylene Chloride Poisoning in a Cabinet Worker 

      Mahmud, M; Kales, Stefanos Nicholas (National Institute of Environmental Health Sciences, 1999)
      More than a million workers are at risk for methylene chloride exposure. Aerosol sprays and paint stripping may also cause significant nonoccupational exposures. After methylene chloride inhalation, significant amounts of ...

    • Methylmercury: significance of intrauterine and postnatal exposures. 

      Grandjean, Philippe; Weihe, Pal; Nielsen, JB (American Association for Clinical Chemistry, 1994)
      Outbreaks of methylmercury poisoning in Japan and Iraq have demonstrated the sensitivity of the fetus to neurotoxic effects. Based on toxicokinetics and considerations of practicability, the optimal biomarker of methylmercury ...

    • Methylome-wide Association Study of Atrial Fibrillation in Framingham Heart Study 

      Lin, Honghuang; Yin, Xiaoyan; Xie, Zhijun; Lunetta, Kathryn L.; Lubitz, Steven A.; Larson, Martin G.; Ko, Darae; Magnani, Jared W.; Mendelson, Michael M.; Liu, Chunyu; McManus, David D.; Levy, Daniel; Ellinor, Patrick T.; Benjamin, Emelia J. (Nature Publishing Group, 2017)
      Atrial fibrillation (AF) is the most common cardiac arrhythmia, but little is known about the molecular mechanisms associated with AF arrhythmogenesis. DNA methylation is an important epigenetic mechanism that regulates ...

    • MetR-Regulated Vibrio cholerae Metabolism Is Required for Virulence 

      Bogard, Ryan William; Davies, Bryan William; Mekalanos, John J. (American Society of Microbiology, 2012)
      LysR-type transcriptional regulators (LTTRs) are the largest, most diverse family of prokaryotic transcription factors, with regulatory roles spanning metabolism, cell growth and division, and pathogenesis. Using a ...

    • mGlu5 receptors and cellular prion protein mediate amyloid-β-facilitated synaptic long-term depression in vivo 

      Hu, Neng-Wei; Nicoll, Andrew J.; Zhang, Dainan; Mably, Alexandra J.; O’Malley, Tiernan; Purro, Silvia A.; Terry, Cassandra; Collinge, John; Walsh, Dominic M.; Rowan, Michael J. (Nature Pub. Group, 2014)
      NMDA-type glutamate receptors (NMDARs) are currently regarded as paramount in the potent and selective disruption of synaptic plasticity by Alzheimer’s disease amyloid β-protein (Aβ). Non-NMDAR mechanisms remain relatively ...

    • MHC Class II haplotypes of Colombian Amerindian tribes 

      Yunis, Juan J.; Yunis, Edmond J.; Yunis, Emilio (Sociedade Brasileira de Genética, 2013)
      We analyzed 1041 individuals belonging to 17 Amerindian tribes of Colombia, Chimila, Bari and Tunebo (Chibcha linguistic family), Embera, Waunana (Choco linguistic family), Puinave and Nukak (Maku-Puinave linguistic ...

    • MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration 

      Cebrián, Carolina; Zucca, Fabio A.; Mauri, Pierluigi; Steinbeck, Julius A.; Studer, Lorenz; Scherzer, Clemens R.; Kanter, Ellen; Budhu, Sadna; Mandelbaum, Jonathan; Vonsattel, Jean P.; Zecca, Luigi; Loike, John D.; Sulzer, David (2014)
      Subsets of rodent neurons are reported to express major histocompatibilty complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA ...

    • Miami Classification for Probe-Based Confocal Laser Endomicroscopy 

      Wallace, M.; Lauwers, Gregory Y.; Chen, Y.; Dekker, E.; Fockens, P.; Sharma, P.; Meining, A. (Thieme Publishing Group, 2011)
      An essential element for any new advanced imaging technology is standardization of indications, terminology, categorization of images, and research priorities. In this review, we propose a state-of-the-art classification ...

    • Mice lacking WRB reveal differential biogenesis requirements of tail-anchored proteins in vivo 

      Rivera-Monroy, Jhon; Musiol, Lena; Unthan-Fechner, Kirsten; Farkas, Ákos; Clancy, Anne; Coy-Vergara, Javier; Weill, Uri; Gockel, Sarah; Lin, Shuh-Yow; Corey, David P.; Kohl, Tobias; Ströbel, Philipp; Schuldiner, Maya; Schwappach, Blanche; Vilardi, Fabio (Nature Publishing Group, 2016)
      Tail-anchored (TA) proteins are post-translationally inserted into membranes. The TRC40 pathway targets TA proteins to the endoplasmic reticulum via a receptor comprised of WRB and CAML. TRC40 pathway clients have been ...

    • Micro- and Nanoengineering Approaches to Control Stem Cell-Biomaterial Interactions 

      Dolatshahi-Pirouz, Alireza; Nikkhah, Mehdi; Kolind, Kristian; Dokmeci, Mehmet R.; Khademhosseini, Ali (MDPI, 2011)
      As our population ages, there is a greater need for a suitable supply of engineered tissues to address a range of debilitating ailments. Stem cell based therapies are envisioned to meet this emerging need. Despite significant ...