Now showing items 1049-1068 of 17918

    • Asbestos Burden Predicts Survival in Pleural Mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Roelofs, Cora R.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Marsit, Carmen J.; Nelson, Heather H.; Kelsey, Karl T. (National Institute of Environmental Health Sciences, 2008)
      Background: Malignant pleural mesothelioma (MPM) is a rapidly fatal asbestos-associated malignancy with a median survival time of < 1 year following diagnosis. Treatment strategy is determined in part using known ...
    • Asbestos exposure predicts cell cycle control gene promoter methylation in pleural mesothelioma 

      Christensen, Brock C.; Godleski, John Joseph; Marsit, Carmen J.; Houseman, Eugene Andres; Lopez-Fagundo, Cristina Y.; Longacker, Jennifer L.; Bueno, Raphael; Sugarbaker, David John; Nelson, Heather H.; Kelsey, Karl T. (Oxford University Press, 2008)
      Malignant pleural mesothelioma (MPM) is a rapidly fatal tumor with increasing incidence worldwide responsible for many thousands of deaths annually. Although there is a clear link between exposure to asbestos and mesothelioma, ...
    • Ascites analysis by a microfluidic chip allows tumor-cell profiling 

      Peterson, Vanessa M.; Castro, Cesar M.; Chung, Jaehoon; Miller, Nathan C.; Ullal, Adeeti V.; Castano, Maria D.; Penson, Richard T.; Lee, Hakho; Birrer, Michael J.; Weissleder, Ralph (National Academy of Sciences, 2013)
      Ascites tumor cells (ATCs) represent a potentially valuable source of cells for monitoring treatment of ovarian cancer as it would obviate the need for more invasive surgical biopsies. The ability to perform longitudinal ...
    • Ascorbic Acid Prevents Loss of Dlk1-Dio3 Imprinting and Facilitates Generation of All-iPS Cell Mice from Terminally Differentiated B Cells 

      Stadtfeld, Matthias; Apostolou, Effie; Chen, Taiping; Oi, Steen; Bestor, Tim; Ferrari, Francesco; Choi, Jiho; Walsh, Ryan Michael; Kim, Sang Yong; Shioda, Toshi; Park, Peter J.; Hochedlinger, Konrad (Nature Publishing Group, 2012)
      The generation of induced pluripotent stem cells (iPSCs) often results in aberrant epigenetic silencing of the imprinted Dlk1-Dio3 gene cluster, compromising the ability to generate entirely iPSC-derived adult mice ('all-iPSC ...
    • Aseptic Meningitis with Craniopharyngioma Resection: Consideration after Endoscopic Surgery 

      Chen, Jenny X.; Alkire, Blake C.; Lam, Allen C.; Curry, William T.; Holbrook, Eric H. (Georg Thieme Verlag KG, 2016)
      Objectives: While bacterial meningitis is a concerning complication after endoscopic skull base surgery, the diagnosis can be made without consideration for aseptic meningitis. This article aims to (1) present a patient ...
    • Asian-White disparities in short sleep duration by industry of employment and occupation in the US: a cross-sectional study 

      Jackson, Chandra L; Kawachi, Ichiro; Redline, Susan; Juon, Hee-Soon; Hu, Frank B (BioMed Central, 2014)
      Background: Although short sleep is associated with an increased risk of morbidity as well as mortality and has been shown to vary by industry of employment and occupation, little is known about the relationship between ...
    • ASM Journals Eliminate Impact Factor Information from Journal Websites 

      Casadevall, Arturo; Bertuzzi, Stefano; Buchmeier, Michael J.; Davis, Roger J.; Drake, Harold; Fang, Ferric C.; Gilbert, Jack; Goldman, Barbara M.; Imperiale, Michael J.; Matsumura, Philip; McAdam, Alexander J.; Pasetti, Marcela F.; Sandri-Goldin, Rozanne M.; Silhavy, Thomas; Rice, Louis; Young, Jo-Anne H.; Shenk, Thomas (American Society for Microbiology, 2016)
      Many scientists attempt to publish their work in a journal with the highest possible journal impact factor (IF). Despite widespread condemnation of the use of journal IFs to assess the significance of published work, these ...
    • Asn 362 in gp120 Contributes to Enhanced Fusogenicity by CCR5-restricted HIV-1 Envelope Glycoprotein Variants from Patients with AIDS 

      Sterjovski, Jasminka; Churchill, Melissa J; Ellett, Anne; Gray, Lachlan R; Roche, Michael J; Dunfee, Rebecca L; Purcell, Damian FJ; Saksena, Nitin; Sonza, Secondo; Wesselingh, Steven L; Karlsson, Ingrid; Fenyo, Eva-Maria; Cunningham, Anthony L; Gorry, Paul R; Wang, Bin; Gabuzda, Dana Helga (BioMed Central, 2007)
      Background: CCR5-restricted (R5) human immunodeficiency virus type 1 (HIV-1) variants cause CD4+ T-cell loss in the majority of individuals who progress to AIDS, but mechanisms underlying the pathogenicity of R5 strains ...
    • Aspects of the Release of Superoxide by Leukocytes, and a Means by Which This Is Switched Off 

      Karnovsky, Manfred L.; Bishop, Amy; Camerero, Valeria C.P.C.; Paz, Mercedes Aurora; Colepicolo, Pio; Ribeiro, Jose M.C.; Gallop, Paul M. (US Department of Health and Human Services, 1994)
      Although great progress has been made in understanding the respiratory burst of leukocytes that produce superoxide (O2-), it is possible that a component or components, might have been overlooked. Furthermore, O2- production ...
    • Aspects of Vitamin A 

      Hedley-Whyte, John; Milamed, Debra (Ulster Medical Society, 2009)
      Musgrave Park Hospital in 1942 was the site of an Anglo-American Vitamin A caper. A threatened court-martial was pre-empted. Subsequently the Queen's lecturer in Anatomy, JW Millen, who was the other lecturer to the first ...
    • Aspergillus Antigen Induces Robust Th2 Cytokine Production, Inflammation, Airway Hyperreactivity and Fibrosis in the Absence of MCP-1 or CCR2 

      Koth, Laura L; Rodriguez, Madeleine W; Bernstein, Xin Liu; Chan, Salina; Huang, Xiaozhu; Charo, Israel F; Rollins, Barrett Jon; Erle, David J (BioMed Central, 2004)
      Background: Asthma is characterized by type 2 T-helper cell (Th2) inflammation, goblet cell hyperplasia, airway hyperreactivity, and airway fibrosis. Monocyte chemoattractant protein-1 (MCP-1 or CCL2) and its receptor, ...
    • Aspirin and Low-Dose Nitric Oxide–Donating Aspirin Increase Life Span in a Lynch Syndrome Mouse Model 

      Mcilhatton, Michael A.; Tyler, Jessica; Kerepesi, Laura A.; Bocker-Edmonston, Tina; Kucherlapati, Melanie; Edelmann, Winfried; Kucherlapati, Raju; Kopelovich, Levy; Fishel, Richard (American Association for Cancer Research (AACR), 2011-05)
      Non-steroidal anti-inflammatory drugs (NSAIDs) appear to be effective cancer chemopreventives. Previous cellular studies demonstrated that aspirin (acetylsalicylic acid: ASA) and nitric oxide-donating ASA (NO-ASA) suppressed ...
    • Aspirin for Primary Prevention of Cardiovascular Events: Meta-Analysis of Randomized Controlled Trials and Subgroup Analysis by Sex and Diabetes Status 

      Xie, Manling; Shan, Zhilei; Zhang, Yan; Chen, Sijing; Yang, Wei; Bao, Wei; Rong, Ying; Yu, Xuefeng; Hu, Frank B.; Liu, Liegang (Public Library of Science, 2014)
      Objective: To evaluate the benefits and harms of aspirin for the primary prevention of CVD and determine whether the effects vary by sex and diabetes status. Methods: We searched Medline, Embase, and Cochrane databases for ...
    • Aspirin intake and breast cancer survival – a nation-wide study using prospectively recorded data in Sweden 

      Holmes, Michelle D; Olsson, Henrik; Pawitan, Yudi; Holm, Johanna; Lundholm, Cecilia; Andersson, Therese M-L; Adami, Hans-Olov; Askling, Johan; Smedby, Karin Ekström (BioMed Central, 2014)
      Background: Aspirin (ASA) use has been associated with improved breast cancer survival in several prospective studies. Methods: We conducted a nested case–control study of ASA use after a breast cancer diagnosis among women ...
    • Aspirin triggers antiinflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial 

      Chiang, Nan; Bermudez, Edmund; Ridker, Paul; Hurwitz, Shelley; Serhan, Charles (National Academy of Sciences, 2004)
      There is increasing evidence that aspirin initiates biosynthesis of novel antiinflammatory mediators by means of interactions between endothelial cells and leukocytes. These mediators are classified as aspirin-triggered ...
    • Aspirin Use and Risk of Atrial Fibrillation in the Physicians' Health Study 

      Ofman, Peter; Petrone, Andrew B.; Peralta, Adelqui; Hoffmeister, Peter; Albert, Christine M.; Djousse, Luc; Gaziano, J. Michael; Rahilly‐Tierney, Catherine R. (Blackwell Publishing Ltd, 2014)
      Background: Inflammatory processes have been associated with an increased risk of atrial fibrillation (AF), potentially allowing for preventive therapy by anti‐inflammatory agents such as aspirin. However, the effect of ...
    • Aspirin-triggered resolvin D1 is produced during self-resolving gram-negative bacterial pneumonia and regulates host immune responses for the resolution of lung inflammation 

      Abdulnour, Raja Elie E.; Sham, Ho Pan; Douda, David N.; Colas, Romain A.; Dalli, Jesmond; Bai, Yan; Ai, Xingbin; Serhan, Charles N.; Levy, Bruce D. (2016)
      Bacterial pneumonia is a leading cause of morbidity and mortality worldwide. Host responses to contain infection and mitigate pathogen-mediated lung inflammation are critical for pneumonia resolution. Aspirin-triggered ...
    • Assembly Line Polyketide Synthases: Mechanistic Insights and Unsolved Problems 

      Khosla, Chaitan; Herschlag, Daniel; Cane, David E.; Walsh, Christopher T. (American Chemical Society, 2014)
      Two hallmarks of assembly line polyketide synthases have motivated an interest in these unusual multienzyme systems, their stereospecificity and their capacity for directional biosynthesis. In this review, we summarize the ...
    • Assembly of a functional Machupo virus polymerase complex 

      Kranzusch, Philip; Schenk, Andreas; Rahmeh, Amal; Radoshitzky, Sheli; Bavari, Sina; Walz, Thomas; Whelan, Sean (National Academy of Sciences, 2010)
      Segmented negative-sense viruses of the family Arenaviridae encode a large polymerase (L) protein that contains all of the enzymatic activities required for RNA synthesis. These activities include an RNA-dependent RNA ...
    • Assess the expression of ubiquitin specific protease USP2a for bladder cancer diagnosis 

      Jeong, Pildu; Ha, Yun-Sok; Yun, Seok-Joong; Yoon, Hyung Yoon; Freeman, Michael R.; Kim, Jayoung; Kim, Wun-Jae (BioMed Central, 2015)
      Background: Given that a deubiquitinating enzyme, ubiquitin-specific protease 2a (USP2a), regulates ubiquitination, trafficking, and degradation of EGFR, which plays a critical role in bladder cancer, in this study, we ...