Browsing HMS Scholarly Articles by Title
Now showing items 10666-10685 of 17918
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MNase titration reveals differences between nucleosome occupancy and chromatin accessibility
(Nature Publishing Group, 2016)Chromatin accessibility plays a fundamental role in gene regulation. Nucleosome placement, usually measured by quantifying protection of DNA from enzymatic digestion, can regulate accessibility. We introduce a metric that ... -
Mobile Antibiotic Resistance Encoding Elements Promote Their Own Diversity
(Public Library of Science, 2009)Integrating conjugative elements (ICEs) are a class of bacterial mobile genetic elements that disseminate via conjugation and then integrate into the host cell genome. The SXT/R391 family of ICEs consists of more than 30 ... -
Mobile HIV Screening in Cape Town, South Africa: Clinical Impact, Cost and Cost-Effectiveness
(Public Library of Science, 2014)Background: Mobile HIV screening may facilitate early HIV diagnosis. Our objective was to examine the cost-effectiveness of adding a mobile screening unit to current medical facility-based HIV testing in Cape Town, South ... -
Mobile Phone Use in Psychiatry Residents in the United States: Multisite Cross-Sectional Survey Study
(JMIR Publications Inc., 2017-11-01)Background Mobile technology ownership in the general US population and medical professionals is increasing, leading to increased use in clinical settings. However, data on use of mobile technology by psychiatry residents ... -
Mobile Robotic Platform for Contactless Vital Sign Monitoring
(American Association for the Advancement of Science (AAAS), 2022-01)The COVID-19 pandemic has accelerated methods to facilitate contactless evaluation of patients in hospital settings. By minimizing unnecessary in-person contact with individuals who may have COVID-19 disease, healthcare ... -
Mobility impairment is associated with reduced microstructural integrity of the inferior and superior cerebellar peduncles in elderly with no clinical signs of cerebellar dysfunction☆
(Elsevier, 2013)While the cerebellum plays a critical role in motor coordination and control no studies have investigated its involvement in idiopathic mobility impairment in community-dwelling elderly. In this study we tested the hypothesis ... -
The MOBILIZE Boston Study: Design and Methods of a Prospective Cohort Study of Novel Risk Factors for Falls in an Older Population
(BioMed Central, 2008)Background: Falls are the sixth leading cause of death in elderly people in the U.S. Despite progress in understanding risk factors for falls, many suspected risk factors have not been adequately studied. Putative risk ... -
MobilomeFINDER: Web-Based Tools for In Silico and Experimental Discovery of Bacterial Genomic Islands
(Oxford University Press, 2007)MobilomeFINDER (http://mml.sjtu.edu.cn/MobilomeFINDER) is an interactive online tool that facilitates bacterial genomic island or ‘mobile genome’ (mobilome) discovery; it integrates the ArrayOme and tRNAcc software packages. ... -
Mode of Delivery and Cord Blood Cytokines: A Birth Cohort Study
(BioMed Central, 2006)Background: The mechanisms for the association between birth by cesarean section and atopy and asthma are largely unknown. Objective: To examine whether cesarean section results in neonatal secretion of cytokines that are ... -
A Model for How Signal Duration Can Determine Distinct Outcomes of Gene Transcription Programs
(Public Library of Science, 2012)The reason why IL-6 induces a pro-inflammatory response, while IL-10 induces an anti-inflammatory response, despite both cytokines activating the same transcription factor, STAT3, is not well understood. It is known that ... -
A model for training medical student innovators: the Harvard Medical School Center for Primary Care Abundance Agents of Change program
(Co-Action Publishing, 2016)Background: In 2013, the Harvard Medical School Center for Primary Care established the Abundance Agents of Change (AoC) program to promote interprofessional learning and innovation, increase partnership between 15 academic ... -
A Model-Based Framework for the Analysis of Miniature Post-Synaptic Currents
(BioMed Central, 2010) -
Model-based lamotrigine clearance changes during pregnancy: clinical implication
(BlackWell Publishing Ltd, 2014)Objective: The objective of the study was to characterize changes in the oral clearance (CL/F) of lamotrigine (LTG) over the course of pregnancy and the postpartum period through a model-based approach incorporating clinical ... -
Model-Driven Analysis of Experimentally Determined Growth Phenotypes for 465 Yeast Gene Deletion Mutants Under 16 Different Conditions
(BioMed Central, 2008)Background: Understanding the response of complex biochemical networks to genetic perturbations and environmental variability is a fundamental challenge in biology. Integration of high-throughput experimental assays and ... -
Modeling \(^{18}F-FDG\) Kinetics during Acute Lung Injury: Experimental Data and Estimation Errors
(Public Library of Science, 2012)Background: There is increasing interest in Positron Emission Tomography (PET) of 2-deoxy-2-[18F]flouro-D-glucose (\(^{18}F-FDG\)) to evaluate pulmonary inflammation during acute lung injury (ALI). We assessed the effect ... -
Modeling a Snap-Action, Variable-Delay Switch Controlling Extrinsic Cell Death
(Public Library of Science, 2008)When exposed to tumor necrosis factor (TNF) or TNF-related apoptosis-inducing ligand (TRAIL), a closely related death ligand and investigational therapeutic, cells enter a protracted period of variable duration in which ... -
Modeling Bacterial Evolution with Comparative-Genome-Based Marker Systems: Application to Mycobacterium tuberculosis Evolution and Pathogenesis
(American Society for Microbiology, 2003)The comparative-genomic sequencing of two Mycobacterium tuberculosis strains enabled us to identify single nucleotide polymorphism (SNP) markers for studies of evolution, pathogenesis, and epidemiology in clinical M. ... -
Modeling contextual effects using individual-level data and without aggregation: an illustration of multilevel factor analysis (MLFA) with collective efficacy
(BioMed Central, 2015)Population health scientists increasingly study how contextual-level attributes affect individual health. A major challenge in this domain relates to measurement, i.e., how best to measure and create variables that capture ... -
Modeling Disease Severity in Multiple Sclerosis Using Electronic Health Records
(Public Library of Science, 2013)Objective: To optimally leverage the scalability and unique features of the electronic health records (EHR) for research that would ultimately improve patient care, we need to accurately identify patients and extract ... -
Modeling HCV disease in animals: virology, immunology and pathogenesis of HCV and GBV-B infections
(Frontiers Media S.A., 2014)Hepatitis C virus (HCV) infection has become a global public health burden costing billions of dollars in health care annually. Even with rapidly advancing scientific technologies this disease still poses a significant ...