Browsing HMS Scholarly Articles by Title
Now showing items 10728-10747 of 17922
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Modifier Genes as Therapeutics: The Nuclear Hormone Receptor Rev Erb Alpha (Nr1d1) Rescues Nr2e3 Associated Retinal Disease
(Public Library of Science, 2014)Nuclear hormone receptors play a major role in many important biological processes. Most nuclear hormone receptors are ubiquitously expressed and regulate processes such as metabolism, circadian function, and development. ... -
Modifiers of Short-term Effects of Ozone on Mortality in Eastern Massachusetts: A Case-crossover Analysis at Individual Level
(BioMed Central, 2010)Background: Substantial epidemiological studies demonstrate associations between exposure to ambient ozone and mortality. A few studies simply examine the modification of this ozone effect by individual characteristics and ... -
Modifying effect of obesity on the association between sitting time and incident diabetes in post-menopausal women
(2013)Objective: To evaluate the association between self-reported daily sitting time and the incidence of type II diabetes in a cohort of postmenopausal women. Design and Methods Women (N = 88,829) without diagnosed diabetes ... -
Modifying Effects of the HFE Polymorphisms on the Association Between Lead Burden and Cognitive Decline
(National Institute of Environmental Health Sciences, 2007)Background: As iron and lead promote oxidative damage, and hemochromatosis (HFE) gene polymorphisms increase body iron burden, HFE variant alleles may modify the lead burden and cognitive decline relationship. Objective: ... -
Modular Approach to Therapy for Anxiety, Depression, Trauma, or Conduct Problems in outpatient child and adolescent mental health services in New Zealand: study protocol for a randomized controlled trial
(BioMed Central, 2015)Background: Mental health disorders are common and disabling for young people because of the potential to disrupt key developmental tasks. Implementation of evidence-based psychosocial therapies in New Zealand is limited, ... -
Modular Evolution of DNA-Binding Preference of a Tbrain Transcription Factor Provides a Mechanism for Modifying Gene Regulatory Networks
(Oxford University Press, 2014)Gene regulatory networks (GRNs) describe the progression of transcriptional states that take a single-celled zygote to a multicellular organism. It is well documented that GRNs can evolve extensively through mutations to ... -
Modular glycosphere assays for high-throughput functional characterization of influenza viruses
(BioMed Central, 2013)Background: The ongoing global efforts to control influenza epidemics and pandemics require high-throughput technologies to detect, quantify, and functionally characterize viral isolates. The 2009 influenza pandemic as ... -
Modulating TRADD to restore cellular homeostasis and inhibit apoptosis
(Springer Science and Business Media LLC, 2020-09-23)Cell death in human disease is often a consequence of disrupted cellular homeostasis. Preventing cell death without restoring cellular homeostasis may lead to a persistent dysfunctional state that remains pathologically ... -
The modulation effect of longitudinal acupuncture on resting state functional connectivity in knee osteoarthritis patients
(BioMed Central, 2015)Recent advances in brain imaging have contributed to our understanding of the neural activity associated with acupuncture treatment. In this study, we investigated functional connectivity across longitudinal acupuncture ... -
Modulation of Acetylation: Creating a Pro-Survival and Anti-Inflammatory Phenotype in Lethal Hemorrhagic and Septic Shock
(Hindawi Publishing Corporation, 2011)Histone deacetylases (HDACs) play a key role in homeostasis of protein acetylation in histone and nonhistone proteins and in regulating fundamental cellular activities. In this paper we review and discuss intriguing recent ... -
Modulation of Alloimmunity by Heat Shock Proteins
(Frontiers Media S.A., 2016)The immunological mechanisms that evolved for host defense against pathogens and injury are also responsible for transplant rejection. Host rejection of foreign tissue was originally thought to be mediated mainly by T cell ... -
Modulation of anxiety and fear via distinct intrahippocampal circuits
(eLife Sciences Publications, Ltd, 2016)Recent findings indicate a high level of specialization at the level of microcircuits and cell populations within brain structures with regards to the control of fear and anxiety. The hippocampus, however, has been treated ... -
Modulation of Autophagy-Like Processes by Tumor Viruses
(MDPI, 2012)Autophagy is an intracellular degradation pathway for long-lived proteins and organelles. This process is activated above basal levels upon cell intrinsic or environmental stress and dysregulation of autophagy has been ... -
Modulation of corticospinal excitability by transcranial magnetic stimulation in children and adolescents with autism spectrum disorder
(Frontiers Media S.A., 2014)The developmental pathophysiology of autism spectrum disorders (ASD) is currently not fully understood. However, multiple lines of evidence suggest that the behavioral phenotype may result from dysfunctional inhibitory ... -
Modulation of Face-sensitive Event-related Potentials by Canonical and Distorted Human Faces: The Role of Vertical Symmetry and Up-Down Featural Arrangement
(MIT Press - Journals, 2006)The study examined the sensitivity of early face-sensitive ERP components to the disruption of two structural properties embedded in faces, namely up-down featural arrangement and vertical asymmetry. Response times and ... -
Modulation of Gene Expression in Key Survival Pathways During Daily Torpor in the Gray Mouse Lemur, Microcebus murinus
(Elsevier, 2015)A variety of mammals employ torpor as an energy-saving strategy in environments of marginal or severe stress either on a daily basis during their inactive period or on a seasonal basis during prolonged multi-day hibernation. ... -
Modulation of gene expression via overlapping binding sites exerted by ZNF143, Notch1 and THAP11
(Oxford University Press, 2013)ZNF143 is a zinc-finger protein involved in the transcriptional regulation of both coding and non-coding genes from polymerase II and III promoters. Our study deciphers the genome-wide regulatory role of ZNF143 in relation ... -
Modulation of Integrin α4β1 (VLA-4) in Dry Eye Disease
(American Medical Association (AMA), 2008)Objective To study the effect of topical application of very late antigen 4 (VLA-4) small-molecule antagonist (anti–VLA-4 sm) in a mouse model of dry eye disease. Methods Anti–VLA-4 sm (or control vehicle) was applied ... -
Modulation of Mcl-1 sensitizes glioblastoma to TRAIL-induced apoptosis
(Springer US, 2013)Glioblastoma (GBM) is the most aggressive form of primary brain tumour, with dismal patient outcome. Treatment failure is associated with intrinsic or acquired apoptosis resistance and the presence of a highly tumourigenic ... -
Modulation of microRNA-mRNA Target Pairs by Human Papillomavirus 16 Oncoproteins
(American Society for Microbiology, 2017)ABSTRACT The E6 and E7 proteins are the major oncogenic drivers encoded by high-risk human papillomaviruses (HPVs). While many aspects of the transforming activities of these proteins have been extensively studied, there ...