Browsing HMS Scholarly Articles by Title

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    • Multichannel vibrotactile display for sensory substitution during teleoperation 

      Debus, Thomas; Becker, Theresia; Dupont, Pierre E; Jang, Tae-Jeong; Howe, Robert D. (SPIE, 2001)
      This paper presents the design and testing of a multi-channel vibrotactile display composed of cylindrical handle with four embedded vibrating elements driven by piezoelectric beams. The experimental goal of the paper is ...

    • Multiclass Cancer Classification by Using Fuzzy Support Vector Machine and Binary Decision Tree With Gene Selection 

      Mao, Yong; Zhou, Xiaobo; Pi, Daoying; Sun, Youxian; Wong, Stephen T. C. (Hindawi Publishing Corporation, 2005)
      We investigate the problems of multiclass cancer classification with gene selection from gene expression data. Two different constructed multiclass classifiers with gene selection are proposed, which are fuzzy support ...

    • Multicomponent Assembly of Proposed DNA Precursors in Water 

      Powner, Matthew W.; Zheng, Shao-Liang; Szostak, Jack William (American Chemical Society, 2012)
      We propose a novel pathway for the prebiotic synthesis of 2′-deoxynucleotides. Consideration of the constitutional chemical relationships between glycolaldehyde and β-mercapto-acetaldehyde, and the corresponding proteinogenic ...

    • A Multicomponent Intervention to Prevent Delirium in Hospitalized Older Patients 

      Inouye, Sharon; Bogardus, Sidney T.; Charpentier, Peter A.; Leo-Summers, Linda; Acampora, Denise; Holford, Theodore R.; Cooney, Leo M. (New England Journal of Medicine (NEJM/MMS), 1999)
      BACKGROUND: Since in hospitalized older patients delirium is associated with poor outcomes, we evaluated the effectiveness of a multicomponent strategy for the prevention of delirium. METHODS: We studied 852 patients ...

    • Multicomponent Targeted Intervention to Prevent Delirium in Hospitalized Older Patients 

      Rizzo, John A.; Bogardus, Sidney T.; Leo-Summers, Linda; Williams, Christianna S.; Acampora, Denise; Inouye, Sharon (Ovid Technologies (Wolters Kluwer Health), 2001)
      Introduction. Delirium, or acute confusional state, is a common and serious occurrence among hospitalized older persons. Current estimates suggest that delirium complicates hospital stays for more than 2.3 million older ...

    • Multicore Assemblies Potentiate Magnetic Properties of Biomagnetic Nanoparticles 

      Yoon, Tae-Jong; Lee, Hakho; Shao, Huilin; Hilderbrand, Scott A.; Weissleder, Ralph (Wiley, 2011)
      Highly potent magnetic nanomaterials are developed by encasing multiple magnetic cores inside a thin silica shell, in much the same way as the pomegranate fruit contains many seeds within a thin skin. This construct not ...

    • Multidetector Computed Tomography Features in Differentiating Exophytic Renal Angiomyolipoma from Retroperitoneal Liposarcoma: A Strobe-Compliant Observational Study 

      Wang, Qiushi; Juan, Yu-Hsiang; Li, Yong; Xie, Jia-Jun; Liu, Hui; Huang, Hongfei; Liu, Zaiyi; Zheng, Junhui; Saboo, Ujwala S.; Saboo, Sachin S.; Liang, Changhong (Wolters Kluwer Health, 2015)
      Abstract This study aims to evaluate the multidetector computed tomography (CT) imaging features in differentiating exophytic renal angiomyolipoma (AML) from retroperitoneal liposarcoma. We retrospectively enrolled 42 ...

    • Multidimensional Dyspnea Profile: an instrument for clinical and laboratory research 

      Banzett, Robert B.; O'Donnell, Carl R.; Guilfoyle, Tegan E.; Parshall, Mark B.; Schwartzstein, Richard M.; Meek, Paula M.; Gracely, Richard H.; Lansing, Robert W. (European Respiratory Society, 2015)
      There is growing awareness that dyspnoea, like pain, is a multidimensional experience, but measurement instruments have not kept pace. The Multidimensional Dyspnea Profile (MDP) assesses overall breathing discomfort, sensory ...

    • Multidimensional heritability analysis of neuroanatomical shape 

      Ge, Tian; Reuter, Martin; Winkler, Anderson M.; Holmes, Avram J.; Lee, Phil H.; Tirrell, Lee S.; Roffman, Joshua L.; Buckner, Randy L.; Smoller, Jordan W.; Sabuncu, Mert R. (Nature Publishing Group, 2016)
      In the dawning era of large-scale biomedical data, multidimensional phenotype vectors will play an increasing role in examining the genetic underpinnings of brain features, behaviour and disease. For example, shape ...

    • Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers 

      Nikolaou, Panayiotis; Coffey, Aaron M.; Ranta, Kaili; Walkup, Laura L.; Gust, Brogan M.; Barlow, Michael J.; Rosen, Matthew S.; Goodson, Boyd M.; Chekmenev, Eduard Y. (American Chemical Society, 2014)
      We present a systematic, multiparameter study of Rb/129Xe spin-exchange optical pumping (SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical-scale stopped-flow hyperpolarizer. In situ ...

    • Multidimensional Measurement of Household Water Poverty in a Mumbai Slum: Looking Beyond Water Quality 

      Subbaraman, Ramnath; Nolan, Laura; Sawant, Kiran; Shitole, Shrutika; Shitole, Tejal; Nanarkar, Mahesh; Patil-Deshmukh, Anita; Bloom, David E. (Public Library of Science, 2015)
      Objective: A focus on bacterial contamination has limited many studies of water service delivery in slums, with diarrheal illness being the presumed outcome of interest. We conducted a mixed methods study in a slum of ...

    • Multidrug Intrinsic Resistance Factors inStaphylococcus aureusIdentified by Profiling Fitness within High-Diversity Transposon Libraries 

      Rajagopal, Mithila; Martin, Melissa Janet; Santiago, Marina Joy; Lee, Wonsik; Kos, Veronica N.; Meredith, Timothy Charles; Gilmore, Michael S.; Kahne, Suzanne Walker (American Society for Microbiology, 2016)
      Staphylococcus aureus is a leading cause of life-threatening infections worldwide. The MIC of an antibiotic against S. aureus, as well as other microbes, is determined by the affinity of the antibiotic for its target in ...

    • Multidrug Resistant Pulmonary Tuberculosis Treatment Regimens and Patient Outcomes: An Individual Patient Data Meta-analysis of 9,153 Patients 

      Ahuja, Shama D.; Ashkin, David; Avendano, Monika; Banerjee, Rita; Bauer, Melissa; Bayona, Jamie N.; Becerra, Mercedes C.; Benedetti, Andrea; Burgos, Marcos; Centis, Rosella; Chan, Eward D.; Chiang, Chen-Yuan; Cox, Helen; D'Ambrosio, Lia; DeRiemer, Kathy; Dung, Nguyen Huy; Enarson, Donald; Falzon, Dennis; Flanagan, Katherine; Flood, Jennifer; Garcia-Garcia, Maria L.; Gandhi, Neel; Granich, Reuben M.; Hollm-Delgado, Maria G.; Holtz, Timothy H.; Iseman, Michael D.; Jarlsberg, Leah G.; Keshavjee, Salmaan A.; Kim, Hye-Ryoun; Koh, Won-Jung; Lancaster, Joey; Lange, Christophe; de Lange, Wiel C. M.; Leimane, Vaira; Leung, Chi Chiu; Li, Jiehui; Menzies, Dick; Migliori, Giovanni B.; Mishustin, Sergey P.; Mitnick, Carole Diane; Narita, Masa; O'Riordan, Philly; Pai, Madhukar; Palmero, Domingo; Park, Seung-kyu; Pasvol, Geoffrey; Peña, Jose; Pérez-Guzmán, Carlos; Quelapio, Maria I. D.; Ponce-de-Leon, Alfredo; Riekstina, Vija; Robert, Jerome; Royce, Sarah; Schaaf, H. Simon; Seung, Kwonjune Justin; Shah, Lena; Shim, Tae Sun; Shin, Sonya Sunhi; Shiraishi, Yuji; Sifuentes-Osornio, José; Sotgiu, Giovanni; Strand, Matthew J.; Tabarsi, Payam; Tupasi, Thelma E.; van Altena, Robert; Van der Walt, Martie; Van der Werf, Tjip S.; Vargas, Mario H.; Viiklepp, Pirett; Westenhouse, Janice; Yew, Wing Wai; Yim, Jae-Joon (Public Library of Science, 2012)
      Background: Treatment of multidrug resistant tuberculosis (MDR-TB) is lengthy, toxic, expensive, and has generally poor outcomes. We undertook an individual patient data meta-analysis to assess the impact on outcomes of ...

    • Multidrug-Resistant Enterococci Lack CRISPR-cas 

      Palmer, K. L.; Gilmore, Michael S. (American Society for Microbiology, 2010)
      Clustered, regularly interspaced short palindromic repeats (CRISPR) provide bacteria and archaea with sequence-specific, acquired defense against plasmids and phage. Because mobile elements constitute up to 25% of the ...

    • Multidrug-Resistant Tuberculosis Management in Resource-Limited Settings 

      Nathanson, Eva; Lambregts-van Weezenbeek, Catharina; Gupta, Rajesh; Blöndal, Kai; Caminero, José A.; Cegielski, J. Peter; Danilovits, Manfred; Espinal, Marcos A.; Hollo, Vahur; Jaramillo, Ernesto; Leimane, Vaira; Nunn, Paul; Pasechnikov, Alexander; Tupasi, Thelma; Wells, Charles; Raviglione, Mario C.; Rich, Michael Leonard; Bayona, Jaime; Mitnick, Carole Diane; Mukherjee, Joia Stapleton (Centers for Disease Control and Prevention, 2006)
      Evidence of successful management of multidrug-resistant tuberculosis (MDRTB) is mainly generated from referral hospitals in high-income countries. We evaluate the management of MDRTB in 5 resource-limited countries: ...

    • Multidrug-resistant tuberculosis treatment failure detection depends on monitoring interval and microbiological method 

      Mitnick, Carole D.; White, Richard A.; Lu, Chunling; Rodriguez, Carly A.; Bayona, Jaime; Becerra, Mercedes C.; Burgos, Marcos; Centis, Rosella; Cohen, Theodore; Cox, Helen; D'Ambrosio, Lia; Danilovitz, Manfred; Falzon, Dennis; Gelmanova, Irina Y.; Gler, Maria T.; Grinsdale, Jennifer A.; Holtz, Timothy H.; Keshavjee, Salmaan; Leimane, Vaira; Menzies, Dick; Migliori, Giovanni Battista; Milstein, Meredith B.; Mishustin, Sergey P.; Pagano, Marcello; Quelapio, Maria I.; Shean, Karen; Shin, Sonya S.; Tolman, Arielle W.; van der Walt, Martha L.; Van Deun, Armand; Viiklepp, Piret (European Respiratory Society, 2016)
      Debate persists about monitoring method (culture or smear) and interval (monthly or less frequently) during treatment for multidrug-resistant tuberculosis (MDR-TB). We analysed existing data and estimated the effect of ...

    • Multidrug-Resistant Tuberculosis Treatment in North Korea: Is Scale-Up Possible? 

      Seung, Kwonjune J.; Franke, Molly; Linton, Stephen W. (Public Library of Science, 2016)
      Kwonjune Seung and colleagues describe the Eugene Bell Foundation's experience of treating MDR-TB in North Korea.

    • A Multiepitope of XBP1, CD138 and CS1 Peptides Induces Myeloma-Specific Cytotoxic T lymphocytes in T cells of Smoldering Myeloma Patients 

      Bae, Jooeun; Prabhala, Rao; Voskertchian, Annie; Brown, Andrew; Maguire, Craig; Richardson, Paul; Dranoff, Glen; Anderson, Kenneth C.; Munshi, Nikhil C. (2014)
      We evaluated a cocktail of HLA-A2-specific peptides including heteroclitic XBP1 US184-192 (YISPWILAV), heteroclitic XBP1 SP367-375 (YLFPQLISV), native CD138260-268 (GLVGLIFAV) and native CS1239-247 (SLFVLGLFL), for their ...

    • Multiethnic Genetic Association Studies Improve Power for Locus Discovery 

      Pulit, Sara L.; Voight, Benjamin F.; de Bakker, Paul I Wen (Public Library of Science, 2010)
      To date, genome-wide association studies have focused almost exclusively on populations of European ancestry. These studies continue with the advent of next-generation sequencing, designed to systematically catalog and ...

    • A Multifunctional AAV–CRISPR–Cas9 and Its Host Response 

      Chew, Wei Leong; Tabebordbar, Mohammadsharif; Cheng, Jason K W; Mali, Prashant; Wu, Elizabeth Y; Ng, Hon Man Alex; Zhu, Kexian; Wagers, Amy; Church, George (Springer Science and Business Media LLC, 2016-09-05)
      CRISPR-Cas9 delivery by AAV holds promise for gene therapy but faces critical barriers due to its potential immunogenicity and limited payload capacity. Here, we demonstrate genome engineering in postnatal mice using ...