Now showing items 11500-11519 of 17918

    • A New Method for Quantitative Immunoblotting of Endogenous α-Synuclein 

      Newman, Andrew J.; Selkoe, Dennis; Dettmer, Ulf (Public Library of Science, 2013)
      β-Sheet-rich aggregates of α-synuclein (αSyn) are the hallmark neuropathology of Parkinson’s disease and related synucleinopathies, whereas the principal native structure of αSyn in healthy cells - unfolded monomer or ...
    • A New Metric for Detecting Change in Slowly Evolving Brain Tumors: Validation in Meningioma Patients 

      Pohl, Kilian M; Konukoglu, Ender; Novellas, Sebastian; Ayache, Nicholas; Fedorov, Andriy; Talos, Ion-Florin; Golby, Alexandra Jacqueline; Wells, William Mercer; Kikinis, Ron; Black, Peter McLaren (Oxford University Press (OUP), 2011)
      BACKGROUND: Change detection is a critical component in the diagnosis and monitoring of many slowly evolving pathologies. OBJECTIVE: This article describes a semiautomatic monitoring approach using longitudinal medical ...
    • A New Paradigm for Individual Subject Language Mapping: Movie-Watching fMRI 

      Tie, Yanmei; Rigolo, Laura; Ozdemir Ovalioglu, Aysegul; Olubiyi, Olutayo I; Doolin, Kelly L.; Mukundan, Srinivasan; Golby, Alexandra Jacqueline (Wiley-Blackwell, 2015)
      BACKGROUND: Functional MRI (fMRI) based on language tasks has been used in presurgical language mapping in patients with lesions in or near putative language areas. However, if patients have difficulty performing the tasks ...
    • A new paradigm for transcription factor TFIIB functionality 

      Gelev, Vladimir; Zabolotny, Janice M.; Lange, Martin; Hiromura, Makoto; Yoo, Sang Wook; Orlando, Joseph S.; Kushnir, Anna; Horikoshi, Nobuo; Paquet, Eric; Bachvarov, Dimcho; Schaffer, Priscilla A.; Usheva, Anny (Nature Publishing Group, 2014)
      Experimental and bioinformatic studies of transcription initiation by RNA polymerase II (RNAP2) have revealed a mechanism of RNAP2 transcription initiation less uniform across gene promoters than initially thought. However, ...
    • The new paradigm of hepatitis C therapy: integration of oral therapies into best practices 

      Afdhal, N H; Zeuzem, S; Schooley, R T; Thomas, D L; Ward, J W; Litwin, A H; Razavi, H; Castera, L; Poynard, T; Muir, A; Mehta, S H; Dee, L; Graham, C; Church, D R; Talal, A H; Sulkowski, M S; Jacobson, I M for the New Paradigm of HCV Therapy Meeting Participants (John Wiley & Sons, 2013)
      SUMMARY. Emerging data indicate that all-oral antiviral treatments for chronic hepatitis C virus (HCV) will become a reality in the near future. In replacing interferon-based therapies, all-oral regimens are expected to ...
    • New Perspectives on Diabetic Vascular Complications: The Loss of Endogenous Protective Factors Induced by Hyperglycemia 

      Jeong, In-Kyung; King, George Liang (Korean Diabetes Association, 2011)
      Diabetic vascular complications are among the leading causes of morbidity and mortality in diabetic patients. In the past, many studies have focused on the mechanisms of hyperglycemia-induced chronic vascular complications ...
    • New Photosensitizers for Photodynamic Therapy 

      Abrahamse, H.; Hamblin, Michael (Portland Press Ltd., 2016-02-09)
      Photodynamic therapy (PDT) was discoveredmore than 100 years ago, and has since become a well-studied therapy for cancer and various non-malignant diseases including infections. PDT uses photosensitizers (PSs, non-toxic ...
    • New players on the metabolic stage 

      Cohen, David E (Landes Bioscience, 2013)
      Members of the acyl-CoA thioesterase (Acot) gene family catalyze the hydrolysis of fatty acyl-CoA thioesters. Thioesterase superfamily member (Them) 1 (synonym: Acot11) is enriched in brown adipose tissue and is markedly ...
    • New Regulatory Paradigms for Innovative Drugs to Treat Pediatric Diseases 

      Hwang, Thomas J; Bourgeois, Florence Tanya (American Medical Association (AMA), 2014)
    • New Social Adaptability Index Predicts Overall Mortality 

      Goldfarb-Rumyantzev, Alexander; Barenbaum, Anna; Rodrigue, James R; Rout, Preeti; Isaacs, Ross; Mukamal, Ken J. (Termedia Publishing House, 2011)
      Introduction: Definitions of underprivileged status based on race, gender and geographic location are neither sensitive nor specific; instead we proposed and validated a composite index of social adaptability (SAI). Material ...
    • A new statistical approach to combining p-values using gamma distribution and its application to genome-wide association study 

      Chen, Zhongxue; Yang, William; Liu, Qingzhong; Yang, Jack Y; Li, Jing; Yang, Mary Qu (BioMed Central, 2014)
      Background: Combining information from different studies is an important and useful practice in bioinformatics, including genome-wide association study, rare variant data analysis and other set-based analyses. Many statistical ...
    • A new statistical method for testing hypotheses of neuropsychological/MRI relationships in schizophrenia: partial least squares analysis 

      Nestor, Paul Gerard; O, Brian F.; McCarley, Robert William; Niznikiewicz, Margaret A.; Barnard, John; Jen Shen, Zi; Bookstein, Fred L.; Shenton, Martha Elizabeth (Elsevier BV, 2002)
      We applied partial least squares (PLS) as a novel multivariate statistical technique to examine neuropsychological correlates of magnetic resonance imaging (MRI) measures of brain volumes in a well studied sample of 15 ...
    • New Susceptibility Loci Associated with Kidney Disease in Type 1 Diabetes 

      Sandholm, Niina; Salem, Rany M.; McKnight, Amy Jayne; Brennan, Eoin P.; Forsblom, Carol; Isakova, Tamara; McKay, Gareth J.; Williams, Winfred Woodrow; Sadlier, Denise M.; Mäkinen, Ville-Petteri; Swan, Elizabeth J.; Palmer, Cameron Douglas; Boright, Andrew P.; Ahlqvist, Emma; Deshmukh, Harshal A.; Keller, Benjamin J.; Huang, Huateng; Ahola, Aila J.; Fagerholm, Emma; Gordin, Daniel; Harjutsalo, Valma; He, Bing; Heikkilä, Outi; Hietala, Kustaa; Kytö, Janne; Lahermo, Päivi; Lehto, Markku; Lithovius, Raija; Österholm, Anne-May; Parkkonen, Maija; Pitkäniemi, Janne; Rosengård-Bärlund, Milla; Saraheimo, Markku; Sarti, Cinzia; Söderlund, Jenny; Soro-Paavonen, Aino; Syreeni, Anna; Thorn, Lena M.; Tikkanen, Heikki; Tolonen, Nina; Tryggvason, Karl; Tuomilehto, Jaakko; Wadén, Johan; Gill, Geoffrey V.; Prior, Sarah Virginie; Guiducci, Candace; Mirel, Daniel B.; Taylor, Andrew; Hosseini, S. Mohsen; Parving, Hans-Henrik; Rossing, Peter; Tarnow, Lise; Ladenvall, Claes; Alhenc-Gelas, François; Lefebvre, Pierre; Rigalleau, Vincent; Roussel, Ronan; Tregouet, David-Alexandre; Maestroni, Anna; Maestroni, Silvia; Falhammar, Henrik; Gu, Tianwei; Möllsten, Anna; Cimponeriu, Danut; Ioana, Mihai; Mota, Maria; Mota, Eugen; Serafinceanu, Cristian; Stavarachi, Monica; Hanson, Robert L.; Nelson, Robert G.; Kretzler, Matthias; Colhoun, Helen M.; Panduru, Nicolae Mircea; Gu, Harvest F.; Brismar, Kerstin; Zerbini, Gianpaolo; Hadjadj, Samy; Marre, Michel; Groop, Leif; Lajer, Maria; Bull, Shelley B.; Waggott, Daryl; Paterson, Andrew D.; Savage, David A.; Bain, Stephen C.; Martin, Finian; Hirschhorn, Joel Naom; Godson, Catherine; Florez, Jose Carlos; Groop, Per-Henrik; Maxwell, Alexander P. (Public Library of Science, 2012)
      Diabetic kidney disease, or diabetic nephropathy (DN), is a major complication of diabetes and the leading cause of end-stage renal disease (ESRD) that requires dialysis treatment or kidney transplantation. In addition to ...
    • New targeted molecular therapies for cancer: radiological response in intrathoracic malignancies and cardiopulmonary toxicity: what the radiologist needs to know 

      Souza, Frederico F; Smith, Andrew; Araujo, Cyrillo; Jagannathan, Jyothi; Johnston, Ciaran; O’Regan, Kevin; Shinagare, Atul; Ramaiya, Nikhil (BioMed Central, 2014)
      The emergence of new novel therapeutic agents which directly target molecules that are uniquely or abnormally expressed in cancer cells (molecular targeted therapy, MTT) has changed dramatically the treatment of cancer in ...
    • New techniques for motion-artifact-free in vivo cardiac microscopy 

      Vinegoni, Claudio; Lee, Sungon; Aguirre, Aaron D.; Weissleder, Ralph (Frontiers Media S.A., 2015)
      Intravital imaging microscopy (i.e., imaging in live animals at microscopic resolution) has become an indispensable tool for studying the cellular micro-dynamics in cancer, immunology and neurobiology. High spatial and ...
    • New Techniques of Recording and Interpretation of Dynamic Coronary Angiography 

      Nguyen, Thach; Nguyen, Duc; Vu, Loc T; Nguyen, Hien Q; Le, Tu NH; Kieu, Thai N; Dinh, Hoang VK; Le, Linh K; Nguyen, Nguyen T; Nguyen, Thinh; Nguyen, Thang; Pham, Tran H; Tran, Khoa; Nguyen, Hao Thuy; Vo, Huy K; Bui, Nhan; Le, Thien C; Mihas, Imran; Singh, Mankirth; Talarico, Ernest; Zuin, Marco; Rigatelli, Gianluca; Nanjundappa, Aravinda; Gibson, Michael (Tan Tao University, 2023-08-15)
      In the study of coronary artery disease (CAD), the mechanism of plaque formation and development was still the subject of continuing debate. The limitation of the current coronary angiogram (CAG) is that it can only show ...
    • New Tools for Comparing Microscopy Images: Quantitative Analysis of Cell Types in Bacillus subtilis 

      van Gestel, Jordi; Vlamakis, Hera; Kolter, Roberto (American Society for Microbiology, 2015)
      Fluorescence microscopy is a method commonly used to examine individual differences between bacterial cells, yet many studies still lack a quantitative analysis of fluorescence microscopy data. Here we introduce some simple ...
    • New Treatments Addressing the Pathophysiology of Hereditary Angioedema 

      Davis, Alvin Ezra (BioMed Central, 2008)
      Hereditary angioedema is a serious medical condition caused by a deficiency of C1-inhibitor. The condition is the result of a defect in the gene controlling the synthesis of C1-inhibitor, which regulates the activity of a ...
    • New Treatments for Chronic Hepatitis C 

      Jang, Jae Young; Chung, Raymond Taeyong (The Korean Association for the Study of the Liver, 2010)
      Treatments for chronic hepatitis C has evolved significantly in the past 15 years. The standard of care (SOC) is peginterferon alfa-2a/-2b with ribavirin for 48 weeks or 24 weeks in patients infected with HCV genotype 1 ...
    • The New Zealand 1986 very low birth weight cohort as young adults: mapping the road ahead 

      Darlow, Brian A.; Horwood, L. John; Woodward, Lianne J.; Elliott, John M.; Troughton, Richard W.; Elder, Mark J.; Epton, Michael J.; Stanton, Josh D.; Swanney, Maureen P.; Keenan, Ross; Melzer, Tracy R.; McKelvey, Victoria A.; Levin, Karelia; Meeks, Margaret G.; Espiner, Eric A.; Cameron, Vicky A; Martin, Julia (BioMed Central, 2015)
      Background: Very low birth weight (less than 1500 g) is associated with increased morbidity and costs of health care in childhood. Emerging evidence suggests these infants face a range of health and social problems as young ...