Browsing HMS Scholarly Articles by Title
Now showing items 11672-11691 of 17922
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Normal Wound Healing and Tumor Angiogenesis as a Game of Competitive Inhibition
(Public Library of Science, 2016)Both normal wound healing and tumor angiogenesis are mitigated by the sequential, carefully orchestrated release of growth stimulators and inhibitors. These regulators are released from platelet clots formed at the sites ... -
Normalization and Experimental Design for ChIP-chip Data
(BioMed Central, 2007)Background: Chromatin immunoprecipitation on tiling arrays (ChIP-chip) has been widely used to investigate the DNA binding sites for a variety of proteins on a genome-wide scale. However, several issues in the processing ... -
A Normalization Model of Attentional Modulation of Single Unit Responses
(Public Library of Science, 2009)Although many studies have shown that attention to a stimulus can enhance the responses of individual cortical sensory neurons, little is known about how attention accomplishes this change in response. Here, we propose ... -
Normalization of Plasma 25-Hydroxy Vitamin D Is Associated with Reduced Risk of Surgery in Crohn’s Disease
(Oxford University Press (OUP), 2013-08-01)Introduction Vitamin D may have an immunological role in Crohn’s disease (CD) and ulcerative colitis (UC). Retrospective studies suggested a weak association between vitamin D status and disease activity but have significant ... -
Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner
(Springer Nature, 2012)The blood vessels of cancerous tumours are leaky1–3 and poorly organized4–7. This can increase the interstitial fluid pressure (IFP) inside tumours and reduce blood supply to them, which impairs drug delivery8–9. Anti-angiogenic ... -
Normalizing acronyms and abbreviations to aid patient understanding of clinical texts: ShARe/CLEF eHealth Challenge 2013, Task 2
(BioMed Central, 2016)Background: The ShARe/CLEF eHealth challenge lab aims to stimulate development of natural language processing and information retrieval technologies to aid patients in understanding their clinical reports. In clinical text, ... -
A Normative Study of the Synovial Fluid Proteome from Healthy Porcine Knee Joints
(American Chemical Society, 2014)Synovial fluid in an articulating joint contains proteins derived from the blood plasma and proteins that are produced by cells within the joint tissues, such as synovium, cartilage, ligament, and meniscus. The proteome ... -
NOS3 Protects Against Systemic Inflammation and Myocardial Dysfunction in Murine Polymicrobial Sepsis
(Ovid Technologies (Wolters Kluwer Health), 2010)NO has been implicated in the pathogenesis of septic shock. However, the role of NO synthase 3 (NOS3) during sepsis remains incompletely understood. Here, we examined the impact of NOS3 deficiency on systemic inflammation ... -
Nosocomial Dengue by Mucocutaneous Transmission
(Centers for Disease Control and Prevention, 2005) -
Not All Are Lost: Interrupted Laboratory Monitoring, Early Death, and Loss to Follow-Up (LTFU) in a Large South African Treatment Program
(Public Library of Science, 2012)Background: Many HIV treatment programs in resource-limited settings are plagued by high rates of loss to follow-up (LTFU). Most studies have not distinguished between those who briefly interrupt, but return to care, and ... -
Not All Missed Doses Are the Same: Sustained NNRTI Treatment Interruptions Predict HIV Rebound at Low-to-Moderate Adherence Levels
(Public Library of Science, 2008)Background: While the relationship between average adherence to HIV potent antiretroviral therapy is well defined, the relationship between patterns of adherence within adherence strata has not been investigated. We examined ... -
Not just gRASping at flaws: Finding vulnerabilities to develop novel therapies for treating KRAS mutant cancers
(BlackWell Publishing Ltd, 2014)Mutations in Kirsten rat-sarcoma (KRAS) are well appreciated to be major drivers of human cancers through dysregulation of multiple growth and survival pathways. Similar to many other non-kinase oncogenes and tumor ... -
Not seeing or feeling is still believing: conscious and non-conscious pain modulation after direct and observational learning
(Nature Publishing Group, 2015)Our experience with the world is shaped not only directly through personal exposure but also indirectly through observing others and learning from their experiences. Using a conditioning paradigm, we investigated how ... -
Notch and MAML-1 Complexation Do Not Detectably Alter the DNA Binding Specificity of the Transcription Factor CSL
(Public Library of Science, 2010)Background: Canonical Notch signaling is initiated when ligand binding induces proteolytic release of the intracellular part of Notch (ICN) from the cell membrane. ICN then travels into the nucleus where it drives the ... -
Notch ligand Delta-like 4 blockade attenuates atherosclerosis and metabolic disorders
(National Academy of Sciences, 2012)Atherosclerosis and insulin resistance are major components of the cardiometabolic syndrome, a global health threat associated with a systemic inflammatory state. Notch signaling regulates tissue development and participates ... -
Notch Modulates Wnt Signalling by Associating With Armadillo/ -Catenin and Regulating Its Transcriptional Activity
(The Company of Biologists, 2005-04-15)The establishment and stability of cell fates during development depend on the integration of multiple signals, which ultimately modulate specific patterns of gene expression. While there is ample evidence for this integration ... -
Notch signal strength controls cell fate in the haemogenic endothelium
(Nature Pub. Group, 2015)Acquisition of the arterial and haemogenic endothelium fates concurrently occur in the aorta–gonad–mesonephros (AGM) region prior to haematopoietic stem cell (HSC) generation. The arterial programme depends on Dll4 and the ... -
Notch Signaling and T-Helper Cells in EAE/MS
(Hindawi Publishing Corporation, 2013)The Notch signaling pathway preservation across species hints to the indispensable role it plays during evolution. Over the last decade the science community has extensively studied the Notch signaling pathway, with Notch ... -
Notch signaling expands a pre-malignant pool of T-cell acute lymphoblastic leukemia clones without affecting leukemia-propagating cell frequency
(2012)NOTCH1 pathway activation contributes to the pathogenesis of over 60% of T-cell acute lymphoblastic leukemia (T-ALL). While Notch is thought to exert the majority of its effects through transcriptional activation of Myc, ...