Browsing HMS Scholarly Articles by Title
Now showing items 11780-11799 of 17922
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A Novel Pro-Angiogenic Function for Interferon-Y–Secreting Natural Killer Cells
(Association for Research in Vision and Ophthalmology (ARVO), 2014)Purpose. To explore the function of natural killer (NK) cells in inflammatory angiogenesis in mice. Methods. To study ocular angiogenic responses we used the cornea BFGF micropellet and the laser-induced choroidal ... -
A Novel Protein Glycan Biomarker and Future Cardiovascular Disease Events
(Blackwell Publishing Ltd, 2014)Background: Glycosylated proteins partake in multiple cellular processes including inflammation. We hypothesized that GlycA, a novel biomarker of protein glycan N‐acetyl groups, is related to incident cardiovascular disease ... -
Novel Proteins Associated With Risk for Coronary Heart Disease or Stroke Among Postmenopausal Women Identified by In-Depth Plasma Proteome Profiling
(BioMed Central, 2010)Background: Coronary heart disease (CHD) and stroke were key outcomes in the Women's Health Initiative (WHI) randomized trials of postmenopausal estrogen and estrogen plus progestin therapy. We recently reported a large ... -
A Novel Quantitative Approach for Eliminating Sample-To-Sample Variation Using a Hue Saturation Value Analysis Program
(Public Library of Science, 2014)Objectives: As computing technology and image analysis techniques have advanced, the practice of histology has grown from a purely qualitative method to one that is highly quantified. Current image analysis software is ... -
Novel recombinant adeno-associated viruses for Cre activated and inactivated transgene expression in neurons
(Frontiers Media S.A., 2012)Understanding the organization of the nervous system requires methods for dissecting the contributions of each component cell type to circuit function. One widely used approach combines genetic targeting of Cre recombinase ... -
A novel recombinant immunotoxin with the smallest ribosome-inactivating protein Luffin P1: T-cell cytotoxicity and prolongation of allograft survival
(Blackwell Publishing Ltd, 2009)Abstract In the creation of stable tolerance to MHC-incompatible allografts, reducing the large mass of donor-reactive cells via apoptosis is often required. Apoptosis induction by immunotoxins targeting surface molecules ... -
A Novel Resolvin-Based Strategy for Limiting Acetaminophen Hepatotoxicity
(Nature Publishing Group, 2016)Objectives: Acetaminophen (APAP)-induced hepatotoxicity is a major cause of morbidity and mortality. The current pharmacologic treatment for APAP hepatotoxicity, N-acetyl cysteine (NAC), targets the initial metabolite-driven ... -
A Novel Reticular Dermal Graft Leverages Architectural and Biological Properties to Support Wound Repair
(Wolters Kluwer Health, 2016)Background: Acellular dermal matrices (ADMs) are frequently used in reconstructive surgery and as scaffolds to treat chronic wounds. The 3-dimensional architecture and extracellular matrix provide structural and signaling ... -
Novel Risk Markers and Long-Term Outcomes of Delirium: The Successful Aging after Elective Surgery (SAGES) Study Design and Methods
(Elsevier BV, 2012)Objectives: Delirium, a costly, life-threatening, and potentially preventable condition, is a common complication for older adults following major surgery. Although the basic epidemiology of delirium after surgery has been ... -
A Novel Role for CCL3 (MIP-1α) in Myeloma-induced Bone Disease via Osteocalcin Downregulation and Inhibition of Osteoblast Function
(2014)Upregulation of cytokines and chemokines is a frequent finding in multiple myeloma (MM). CCL3 (also known as MIP-1α) is a pro-inflammatory chemokine whose levels in the MM microenvironment correlate with osteolytic lesions ... -
A Novel Role for Mc1r in the Parallel Evolution of Depigmentation in Independent Populations of the Cavefish Astyanax mexicanus
(Public Library of Science, 2009)The evolution of degenerate characteristics remains a poorly understood phenomenon. Only recently has the identification of mutations underlying regressive phenotypes become accessible through the use of genetic analyses. ... -
A novel role for RIP1 kinase in mediating TNFα production
(Nature Publishing Group, 2012)Receptor-interacting protein 1 (RIP1) is a Ser/Thr kinase with both kinase-dependent and kinase-independent roles in death receptor signaling. The kinase activity of RIP1 is required for necroptosis, a caspase-independent ... -
A novel role of CD4 Th17 cells in mediating cardiac allograft rejection and vasculopathy
(The Rockefeller University Press, 2008)T-bet plays a crucial role in Th1 development. We investigated the role of T-bet in the development of allograft rejection in an established MHC class II–mismatched (bm12 into B6) model of chronic allograft vasculopathy ... -
A novel role of sphingosine 1-phosphate receptor S1pr1 in mouse thrombopoiesis
(The Rockefeller University Press, 2012)Millions of platelets are produced each hour by bone marrow (BM) megakaryocytes (MKs). MKs extend transendothelial proplatelet (PP) extensions into BM sinusoids and shed new platelets into the blood. The mechanisms that ... -
Novel Roles for MLH3 Deficiency and TLE6-Like Amplification in DNA Mismatch Repair-Deficient Gastrointestinal Tumorigenesis and Progression
(Public Library of Science, 2008)DNA mismatch repair suppresses gastrointestinal tumorgenesis. Four mammalian E. coli MutL homologues heterodimerize to form three distinct complexes: MLH1/PMS2, MLH1/MLH3, and MLH1/PMS1. To understand the mechanistic ... -
A Novel SALL4/OCT4 Transcriptional Feedback Network for Pluripotency of Embryonic Stem Cells
(Public Library of Science, 2010)Background: SALL4 is a member of the SALL gene family that encodes a group of putative developmental transcription factors. Murine Sall4 plays a critical role in maintaining embryonic stem cell (ES cell) pluripotency and ... -
Novel Secretion Apparatus Maintains Spore Integrity and Developmental Gene Expression in Bacillus subtilis
(Public Library of Science, 2009)Sporulation in Bacillus subtilis involves two cells that follow separate but coordinately regulated developmental programs. Late in sporulation, the developing spore (the forespore) resides within a mother cell. The ... -
A Novel Service-Oriented Professional Development Program for Research Assistants at an Academic Hospital: A Web-Based Survey
(JMIR Publications Inc., 2015)Background: Research assistants (RAs) are hired at academic centers to staff the research and quality improvement projects that advance evidence-based medical practice. Considered a transient population, these young ... -
A Novel Small-Molecule Tumor Necrosis Factor \(\alpha\) Inhibitor Attenuates Inflammation in a Hepatitis Mouse Model
(American Society for Biochemistry & Molecular Biology (ASBMB), 2014)Over-expression of tumor necrosis factor α (TNFα) is a hallmark of many inflammatory diseases including rheumatoid arthritis, inflammatory bowel disease and septic shock and hepatitis, making it a potential therapeutic ... -
Novel Strategies for Drug Discovery Based on Intrinsically Disordered Proteins (IDPs)
(Molecular Diversity Preservation International, 2011)Intrinsically disordered proteins (IDPs) are proteins that usually do not adopt well-defined native structures when isolated in solution under physiological conditions. Numerous IDPs have close relationships with human ...