Browsing HMS Scholarly Articles by Title

Now showing items 11906-11925 of 17922

    • Objective Sequence-Based Subfamily Classifications of Mouse Homeodomains Reflect Their In Vitro DNA-Binding Preferences 

      Santos, Miguel A.; Turinsky, Andrei L.; Ong, Serene; Tsai, Jennifer; Berger, Michael F.; Badis, Gwenael; Talukder, Shaheynoor; Gehrke, Andrew R.; Hughes, Timothy R.; Wodak, Shoshana J.; Bulyk, Martha Leonia (Oxford University Press, 2010)
      Classifying proteins into subgroups with similar molecular function on the basis of sequence is an important step in deriving reliable functional annotations computationally. So far, however, available classification ...

    • Objectively measured physical activity and sedentary behaviour and ankle brachial index: Cross-sectional and longitudinal associations in older men 

      Parsons, Tessa J.; Sartini, Claudio; Ellins, Elizabeth A.; Halcox, Julian P.J.; Smith, Kirsten E.; Ash, Sarah; Lennon, Lucy T.; Wannamethee, S. Goya; Lee, I-Min; Whincup, Peter H.; Jefferis, Barbara J. (Elsevier, 2016)
      Background: Associations between bouts of physical activity (PA), sedentary behaviour (SB) and cardiovascular disease, and their mutual independence are not well defined. A low ankle brachial index (ABI ≤0.9) indicates ...

    • Objectively measured physical activity, sedentary time and subclinical vascular disease: Cross-sectional study in older British men 

      Parsons, Tessa J.; Sartini, Claudio; Ellins, Elizabeth A.; Halcox, Julian P.J.; Smith, Kirsten E.; Ash, Sarah; Lennon, Lucy T.; Wannamethee, S. Goya; Lee, I-Min; Whincup, Peter H.; Jefferis, Barbara J. (Academic Press, 2016)
      Low physical activity (PA) and high levels of sedentary time (ST) are associated with higher cardiovascular disease (CVD) risk among older people. However, their independent contribution and importance of duration of PA ...

    • An Obligate Role of Oxytocin Neurons in Diet Induced Energy Expenditure 

      Wu, Zhaofei; Xu, Yuanzhong; Zhu, Yaming; Sutton, Amy K.; Zhao, Rongjie; Lowell, Bradford Barr; Olson, David Paul; Tong, Qingchun (Public Library of Science, 2012)
      Oxytocin neurons represent one of the major subsets of neurons in the paraventricular hypothalamus (PVH), a critical brain region for energy homeostasis. Despite substantial evidence supporting a role of oxytocin in body ...

    • Observational Cohort Study of the Safety of Digoxin Use in Women with Heart Failure 

      Flory, James H; Ky, Bonnie; Haynes, Kevin; Brunelli, Steven M.; Munson, Jeffrey; Rowan, Christopher; Strom, Brian L; Hennessy, Sean (BMJ Group, 2012)
      Objectives: This study aims to assess whether digoxin has a different effect on mortality risk for women than it does for men in patients with heart failure (HF). Design This study uses the UK-based The Health Information ...

    • An Observational Report of Intensive Robotic and Manual Gait Training in Sub-acute Stroke 

      Conesa, Lucas; Costa, Úrsula; Morales, Eva; Edwards, Dylan James; Cortes, Mar; León, Daniel; Bernabeu, Montserrat; Medina, Josep (BioMed Central, 2012)
      Background: The use of automated electromechanical devices for gait training in neurological patients is increasing, yet the functional outcomes of well-defined training programs using these devices and the characteristics ...

    • Observational Study of Changes in Epidural Pressure and Elastance During Epidural Blood Patch in Obstetric Patients 

      Pratt, Stephen Douglas; Kaczka, D; Hess, Philip E. (Elsevier BV, 2014)
      Background During an epidural blood patch, we inject blood until the patient describes mild back pressure, often leading to injection of more than 20 mL of blood. We undertook this study to measure the epidural pressures ...

    • Observing the cell in its native state: Imaging subcellular dynamics in multicellular organisms 

      Liu, Tsung-Li; Upadhyayula, Srigokul; Milkie, Daniel E.; Singh, Ved; Wang, Kai; Swinburne, Ian A.; Mosaliganti, Kishore R.; Collins, Zach M.; Hiscock, Tom W.; Shea, Jamien; Kohrman, Abraham Q.; Medwig, Taylor N.; Dambournet, Daphne; Forster, Ryan; Cunniff, Brian; Ruan, Yuan; Yashiro, Hanako; Scholpp, Steffen; Meyerowitz, Elliot M.; Hockemeyer, Dirk; Drubin, David G.; Martin, Benjamin L.; Matus, David Q.; Koyama, Minoru; Megason, Sean G.; Kirchhausen, Tom; Betzig, Eric (American Association for the Advancement of Science (AAAS), 2018-04-20)
      The living cell contains dynamic, spatially complex subassemblies that are sensitive to external perturbations. To minimize such perturbations, cells should be imaged in their native multicellular environments, under as ...

    • An OBSL1-Cul7\(^{\text{Fbxw8}}\) Ubiquitin Ligase Signaling Mechanism Regulates Golgi Morphology and Dendrite Patterning 

      Litterman, Nadia Kathryn; Ikeuchi, Yoshiho; Gallardo, Gilbert; O'Connell, Brenda C.; Sowa, Mathew E.; Gygi, Steven P.; Harper, J. Wade; Bonni, Azad (Public Library of Science, 2011)
      The elaboration of dendrites in neurons requires secretory trafficking through the Golgi apparatus, but the mechanisms that govern Golgi function in neuronal morphogenesis in the brain have remained largely unexplored. ...

    • Obstructed Labor and Caesarean Delivery: The Cost and Benefit of Surgical Intervention 

      Alkire, Blake Christian; Vincent, Jeffrey R.; Burns, Christy Turlington; Metzler, Ian Scott; Farmer, Paul Edward; Meara, John Gerard (Public Library of Science, 2012)
      Background: Although advances in the reduction of maternal mortality have been made, up to 273,000 women will die this year from obstetric etiologies. Obstructed labor (OL), most commonly treated with Caesarean delivery, ...

    • Obstructive Sleep Apnea Alters Sleep Stage Transition Dynamics 

      Bianchi, Matt Travis; Cash, Sydney S.; Mietus, Joseph; Peng, Chung-Kang; Thomas, Robert Joseph (Public Library of Science (PLoS), 2010)
      Introduction: Enhanced characterization of sleep architecture, compared with routine polysomnographic metrics such as stage percentages and sleep efficiency, may improve the predictive phenotyping of fragmented sleep. One ...

    • Obstructive Sleep Apnea and Cardiovascular Disease: Back and Forward in Time Over the Last 25 Years 

      Quan, Stuart (2012)
      Over the past 25 years, there have been significant advances made in understanding the pathophysiology and cardiovascular consequences of obstructive sleep apnea (OSA). Substantial evidence now implicates OSA as an independent ...

    • Obstructive Sleep Apnea and Progression of Coronary Artery Calcium: The Multi‐Ethnic Study of Atherosclerosis Study 

      Kwon, Younghoon; Duprez, Daniel A.; Jacobs, David R.; Nagayoshi, Mako; McClelland, Robyn L.; Shahar, Eyal; Budoff, Matthew; Redline, Susan; Shea, Steven; Carr, J. Jeffrey; Lutsey, Pamela L. (Blackwell Publishing Ltd, 2014)
      Background: Obstructive sleep apnea (OSA) is a common condition associated with cardiovascular disease. Its potential effect on progression of subclinical atherosclerosis is not well understood. We tested the hypothesis ...

    • Obstructive sleep apnea and psychomotor vigilance task performance 

      Batool-Anwar, Salma; Kales, Stefanos N; Patel, Sanjay R; Varvarigou, Vasileia; DeYoung, Pamela N; Malhotra, Atul (Dove Medical Press, 2014)
      Background: Obstructive sleep apnea (OSA) is a highly prevalent disorder with considerable morbidity and mortality. Vigilance and attentiveness are often impaired in OSA patients. In occupational medicine settings, subjective ...

    • Obstructive sleep apnea and quality of life: comparison of the SAQLI, FOSQ, and SF-36 questionnaires 

      Silva, Graciela; Goodwin, James; Vana, Kimberly; Quan, Stuart Fun (Southwest Journal of Pulmonary and Critical Care, 2016)
      Introduction: The impact of sleep on quality of life (QoL) has been well documented; however, there is a great need for reliable QoL measures for persons with obstructive sleep apnea (OSA). We compared the QoL scores ...

    • Obstructive Sleep Apnea in North American Commercial Drivers 

      KALES, Stefanos N.; STRAUBEL, Madeleine G. (National Institute of Occupational Safety and Health, Japan, 2014)
      The most common medical cause of excessive daytime sleepiness (EDS) is obstructive sleep apnea (OSA). Specifically, among an estimated 14 million US commercial drivers, 17–28% or 2.4 to 3.9 million are expected to have ...

    • Occipital lobe gray matter volume in male patients with chronic schizophrenia: A quantitative MRI study 

      Onitsuka, Toshiaki; McCarley, Robert William; Kuroki, Noriomi; Dickey, Chandlee C.; Kubicki, Marek R.; Demeo, Susan S.; Frumin, Melissa; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (Elsevier BV, 2007)
      Schizophrenia is characterized by deficits in cognition as well as visual perception. There have, however, been few magnetic resonance imaging (MRI) studies of the occipital lobe as an anatomically defined region of interest ...

    • Occult Langerhans Cell Histiocytosis Presenting with Papillary Thyroid Carcinoma, a Thickened Pituitary Stalk and Diabetes Insipidus 

      Gordon, Michael S.; Gordon, Murray B. (Hindawi Publishing Corporation, 2016)
      Etiologies of a thickened stalk include inflammatory, neoplastic, and idiopathic origins, and the underlying diagnosis may remain occult. We report a patient with a thickened pituitary stalk (TPS) and papillary thyroid ...

    • Occupational and environmental lung diseases: an overview. 

      Speizer, Frank Erwin (2000)

    • Occupational Deaths among Healthcare Workers 

      Sepkowitz, Kent A.; Eisenberg, Leon (Centers for Disease Control and Prevention, 2005)
      Recent experiences with severe acute respiratory syndrome and the US smallpox vaccination program have demonstrated the vulnerability of healthcare workers to occupationally acquired infectious diseases. However, despite ...