Browsing HMS Scholarly Articles by Title
Now showing items 11965-11984 of 17922
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On Diffusion Tensor Estimation
(IEEE, 2006)In this paper we propose a formal formulation for the estimation of Diffusion Tensors in the space of symmetric positive semidefinite (PSD) tensors. Traditionally, diffusion tensor model estimation has been carried out ... -
On evaluating brain tissue classifiers without a ground truth
(Elsevier BV, 2007)In this paper, we present a set of techniques for the evaluation of brain tissue classifiers on a large data set of MR images of the head. Due to the difficulty of establishing a gold standard for this type of data, we ... -
On Holo-Hilbert spectral analysis: a full informational spectral representation for nonlinear and non-stationary data
(The Royal Society Publishing, 2016)The Holo-Hilbert spectral analysis (HHSA) method is introduced to cure the deficiencies of traditional spectral analysis and to give a full informational representation of nonlinear and non-stationary data. It uses a nested ... -
On Quality Control Measures in Genome-wide Association Studies: A Test to Assess the Genotyping Quality of Individual Probands in Family-based Association Studies and an Application to the HapMap Data
(Public Library of Science, 2009)Allele transmissions in pedigrees provide a natural way of evaluating the genotyping quality of a particular proband in a family-based, genome-wide association study. We propose a transmission test that is based on this ... -
On the alert: future priorities for alerts in clinical decision support for computerized physician order entry identified from a European workshop
(BioMed Central, 2013)Background: Clinical decision support (CDS) for electronic prescribing systems (computerized physician order entry) should help prescribers in the safe and rational use of medicines. However, the best ways to alert users ... -
On the Analysis of Genome-Wide Association Studies in Family-Based Designs: A Universal, Robust Analysis Approach and an Application to Four Genome-Wide Association Studies
(Public Library of Science, 2009)For genome-wide association studies in family-based designs, we propose a new, universally applicable approach. The new test statistic exploits all available information about the association, while, by virtue of its design, ... -
On the Bayesian Derivation of a Treatment-based Cancer Ontology
(American Medical Informatics Association, 2014)Traditional cancer classifications are primarily based on anatomical locations. As knowledge is heavily compartmentalized in the oncological specialties, discovering new targets for existing drugs (drug inference) can take ... -
On the design of clone-based haplotyping
(BioMed Central, 2013)Background: Haplotypes are important for assessing genealogy and disease susceptibility of individual genomes, but are difficult to obtain with routine sequencing approaches. Experimental haplotype reconstruction based on ... -
On the epidemiology of influenza
(BioMed Central, 2008)The epidemiology of influenza swarms with incongruities, incongruities exhaustively detailed by the late British epidemiologist, Edgar Hope-Simpson. He was the first to propose a parsimonious theory explaining why influenza ... -
On the Epidemiology of Influenza: Reply to Radonovich et al
(BioMed Central, 2009)On the epidemiology of influenza: reply to Radonovich LJ, Martinello RA, Hodgson M, Milton DK, Nardell EA. Influenza and ultraviolet germicidal irradiation. Virol J. 2008, 5:149 -
On the Interactions between Virulent Bacteriophages and Bacteria in the gut
(Landes Bioscience, 2013)We recently described the targeting of O104:H4 Escherichia coli in mouse gut by several virulent bacteriophages, highlighting several issues relating to virus-host interactions, which we discuss further in this addendum ... -
On the Minimization of Fluctuations in the Response Times of Autoregulatory Gene Networks
(Elsevier BV, 2011)The temporal dynamics of the concentrations of several proteins are tightly regulated, particularly for critical nodes in biological networks such as transcription factors. An important mechanism to control transcription ... -
On the near-wall accumulation of injectable particles in the microcirculation: smaller is not better
(Nature Publishing Group, 2013)Although most nanofabrication techniques can control nano/micro particle (NMP) size over a wide range, the majority of NMPs for biomedical applications exhibits a diameter of ~100 nm. Here, the vascular distribution of ... -
On the Nose
(New England Journal of Medicine (NEJM/MMS), 2015)A 67-year-old man presented with a 3-day history of chest tightness, wheezing, coughing, and dyspnea. He had a history of asthma but had not had major exacerbations for 20 years. He did not have fever, sputum production, ... -
On the Origins and Control of Community Types in the Human Microbiome
(Public Library of Science, 2016)Microbiome-based stratification of healthy individuals into compositional categories, referred to as “enterotypes” or “community types”, holds promise for drastically improving personalized medicine. Despite this potential, ... -
On the Recombination Rate Estimation in the Presence of Population Substructure
(Public Library of Science, 2015)As recombination events are not uniformly distributed along the human genome, the estimation of fine-scale recombination maps, e.g. HapMap Project, has been one of the major research endeavors over the last couple of years. ... -
On the Sources of the Height–Intelligence Correlation: New Insights from a Bivariate ACE model with Assortative Mating
(Springer US, 2010)A robust positive correlation between height and intelligence, as measured by IQ tests, has been established in the literature. This paper makes several contributions toward establishing the causes of this association. ... -
On the Understanding and Development of Modern Physical Neurorehabilitation Methods: Robotics and Non-invasive Brain Stimulation
(BioMed Central, 2009)The incidence of physical disability in the community resulting from neurological dysfunction is predicted to increase in the coming years. The impetus for immediate and critical evaluation of physical neurorehabilitation ... -
On the use of propensity scores in case of rare exposure
(BioMed Central, 2016)Background: Observational post-marketing assessment studies often involve evaluating the effect of a rare treatment on a time-to-event outcome, through the estimation of a marginal hazard ratio. Propensity score (PS) methods ... -
On-Chip Bioorthogonal Chemistry Enables Immobilization of in Situ Modified Nanoparticles and Small Molecules for Label-Free Monitoring of Protein Binding and Reaction Kinetics
(Royal Society of Chemistry, 2012)Efficient methods to immobilize small molecules under continuous-flow microfluidic conditions would greatly improve label-free molecular interaction studies using biosensor technology. At present, small-molecule immobilization ...