Browsing HMS Scholarly Articles by Title

Now showing items 12047-12066 of 17922

    • Optical coherence tomography angiography in pediatric choroidal neovascularization 

      Veronese, Chiara; Maiolo, Chiara; Huang, David; Jia, Yali; Armstrong, Grayson W.; Morara, Mariachiara; Ciardella, Antonio P. (2016)
      Purpose To report two cases of pediatric choroidal neovascularization (CNV) and the associated neo-vascular and retinal findings identified on Optical Coherence Tomography Angiography (OCTA) imaging. Methods: A 14-year-old ...

    • Optical Control of Mammalian Endogenous Transcription and Epigenetic States 

      Konermann, Silvana; Brigham, Mark D.; Trevino, Alexandro; Hsu, Patrick D.; Heidenreich, Matthias; Cong, Le; Platt, Randall J.; Scott, David A.; Church, George M.; Zhang, Feng (2013)
      The dynamic nature of gene expression enables cellular programming, homeostasis, and environmental adaptation in living systems. Dissection of causal gene functions in cellular and organismal processes therefore necessitates ...

    • Optical Endomicroscopy and the Road to Real-Time, In Vivo Pathology: Present and Future 

      Carignan, Charles S; Yagi, Yukako (BioMed Central, 2012)
      Epithelial cancers account for substantial mortality and are an important public health concern. With the need for earlier detection and treatment of these malignancies, the ability to accurately detect precancerous lesions ...

    • Optical Imaging of Apoptosis as a Biomarker of Tumor Response to Chemotherapy 

      Schellenberger, Eyk A.; Bogdanov, Alexei, Jr.; Petrovsky, Alexander; Ntziachristos, Vasilis; Weissleder, Ralph; Josephson, Lee (Elsevier, 2003)
      A rapid and accurate assessment of the antitumor efficacy of new therapeutic drugs could speed up drug discovery and improve clinical decision making. Based on the hypothesis that most effective antitumor agents induce ...

    • Optical Imaging of Mesenchymal Epithelial Transition Factor (MET) for Enhanced Detection and Characterization of Primary and Metastatic Hepatic Tumors 

      Esfahani, Shadi A.; Heidari, Pedram; Kim, Sun A.; Ogino, Shuji; Mahmood, Umar (Ivyspring International Publisher, 2016)
      Purpose: To assess optical imaging of Mesenchymal-Epithelial Transition factor (MET) for delineation and characterization of intrahepatic models of human hepatocellular carcinoma (HCC) and metastatic colorectal cancer ...

    • Optical Imaging with a Cathepsin B Activated Probe for the Enhanced Detection of Esophageal Adenocarcinoma by Dual Channel Fluorescent Upper GI Endoscopy 

      Habibollahi, Peiman; Figueiredo, Jose-Luiz; Heidari, Pedram; Dulak, Austin M; Imamura, Yu; Bass, Adam Joel; Ogino, Shuji; Chan, Andrew Tan; Mahmood, Umar (Ivyspring International Publisher, 2012)
      Despite significant advances in diagnosis and treatment, the prognosis of esophageal adenocarcinoma remains poor highlighting the importance of early detection. Although white light (WL) upper endoscopy can be used for ...

    • Optical lens-microneedle array for percutaneous light delivery 

      Kim, Moonseok; An, Jeesoo; Kim, Ki Su; Choi, Myunghwan; Matjaž Humar; Kwok, Sheldon; Dai, Tianhong; Yun, Seok Hyun (Optical Society of America, 2016)
      The limited penetration depth of light in skin tissues is a practical bottleneck in dermatologic applications of light-induced therapies, including anti-microbial blue light therapy and photodynamic skin cancer therapy. ...

    • Optical measurement of arterial mechanical properties: from atherosclerotic plaque initiation to rupture 

      Nadkarni, Seemantini K. (Society of Photo-Optical Instrumentation Engineers, 2013)
      Abstract. During the pathogenesis of coronary atherosclerosis, from lesion initiation to rupture, arterial mechanical properties are altered by a number of cellular, molecular, and hemodynamic processes. There is growing ...

    • Optical visualisation of individual biomolecules in densely packed clusters 

      Dai, Mingjie; Jungmann, Ralf; Yin, Peng (2016)
      Recent advances in fluorescence super-resolution microscopy have allowed sub-cellular features and synthetic nanostructures down to ~15 nm in size to be imaged. However, direct optical observation of individual molecular ...

    • Optical-domain subsampling for data efficient depth ranging in Fourier-domain optical coherence tomography 

      Siddiqui, Meena; Vakoc, Benjamin J. (Optical Society of America, 2012)
      Recent advances in optical coherence tomography (OCT) have led to higher-speed sources that support imaging over longer depth ranges. Limitations in the bandwidth of state-of-the-art acquisition electronics, however, prevent ...

    • Optimal body weight for health and longevity: bridging basic, clinical, and population research 

      Fontana, Luigi; Hu, Frank B (BlackWell Publishing Ltd, 2014)
      Excess body weight and adiposity cause insulin resistance, inflammation, and numerous other alterations in metabolic and hormonal factors that promote atherosclerosis, tumorigenesis, neurodegeneration, and aging. Studies ...

    • Optimal Brain MRI Protocol for New Neurological Complaint 

      Mehan, William A.; González, R. Gilberto; Buchbinder, Bradley R.; Chen, John W.; Copen, William A.; Gupta, Rajiv; Hirsch, Joshua A.; Hunter, George J.; Hunter, Scott; Johnson, Jason M.; Kelly, Hillary R.; Larvie, Mykol; Lev, Michael H.; Pomerantz, Stuart R.; Rapalino, Otto; Rincon, Sandra; Romero, Javier M.; Schaefer, Pamela W.; Shah, Vinil (Public Library of Science, 2014)
      Background/Purpose Patients with neurologic complaints are imaged with MRI protocols that may include many pulse sequences. It has not been documented which sequences are essential. We assessed the diagnostic accuracy of ...

    • Optimal Cutoff Levels of More Sensitive Cardiac Troponin Assays for the Early Diagnosis of Myocardial Infarction in Patients With Renal Dysfunction 

      Twerenbold, Raphael; Wildi, Karin; Jaeger, Cedric; Gimenez, Maria Rubini; Reiter, Miriam; Reichlin, Tobias; Walukiewicz, Astrid; Gugala, Mathias; Krivoshei, Lian; Marti, Nadine; Moreno Weidmann, Zoraida; Hillinger, Petra; Puelacher, Christian; Rentsch, Katharina; Honegger, Ursina; Schumacher, Carmela; Zurbriggen, Felicitas; Freese, Michael; Stelzig, Claudia; Campodarve, Isabel; Bassetti, Stefano; Osswald, Stefan; Mueller, Christian (Lippincott Williams & Wilkins, 2015)
      Background— It is unknown whether more sensitive cardiac troponin (cTn) assays maintain their clinical utility in patients with renal dysfunction. Moreover, their optimal cutoff levels in this vulnerable patient population ...

    • Optimal Lifestyle Components in Young Adulthood Are Associated With Maintaining the Ideal Cardiovascular Health Profile Into Middle Age 

      Gooding, Holly C.; Shay, Christina M.; Ning, Hongyan; Gillman, Matthew W.; Chiuve, Stephanie E.; Reis, Jared P.; Allen, Norrina B.; Lloyd‐Jones, Donald M. (John Wiley and Sons Inc., 2015)
      Background: Middle‐aged adults with ideal blood pressure, cholesterol, and glucose levels exhibit substantially lower cardiovascular mortality than those with unfavorable levels. Four healthy lifestyle components—optimal ...

    • Optimal Long-Acting Injectable Antipsychotic Management During COVID-19 

      MacLaurin, Sarah A.; Mulligan, Caitlin; Van Alphen, Manjola Ujkaj; Freudenreich, Oliver (Physicians Postgraduate Press, Inc, 2021-01-12)
      N/A (letter)

    • Optimal management of hereditary hemorrhagic telangiectasia 

      Garg, Neetika; Khunger, Monica; Gupta, Arjun; Kumar, Nilay (Dove Medical Press, 2014)
      Hereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler–Weber–Rendu syndrome, is a group of related disorders inherited in an autosomal dominant fashion and characterized by the development of arteriovenous ...

    • Optimal policy for value-based decision-making 

      Tajima, Satohiro; Drugowitsch, Jan; Pouget, Alexandre (Nature Publishing Group, 2016)
      For decades now, normative theories of perceptual decisions, and their implementation as drift diffusion models, have driven and significantly improved our understanding of human and animal behaviour and the underlying ...

    • Optimal Workloop Energetics of Muscle-Actuated Systems: An Impedance Matching View 

      Farahat, Waleed A.; Herr, Hugh M. (Public Library of Science, 2010)
      Integrative approaches to studying the coupled dynamics of skeletal muscles with their loads while under neural control have focused largely on questions pertaining to the postural and dynamical stability of animals and ...

    • Optimism and the Socioeconomic Status Gradient in Adolescent Adiposity 

      Khullar, Dhruv; Oreskovic, Nicolas Michel; Perrin, James Marc; Goodman, Elizabeth (Elsevier BV, 2011)
      Purpose: To assess if dispositional optimism is associated with adiposity and explore if dispositional optimism mediates the relationship between parent education and adiposity (BMI z score). Methods: Multivariable regression ...

    • Optimization and control in bacterial Lag phase 

      Schultz, Daniel; Kishony, Roy (BioMed Central, 2013)
      The lag phase of bacterial growth is important from a medical and food safety perspective, but difficult to study due to the low density and metabolic rate of cells. A new study by Alon and colleagues reveals that the gene ...