Browsing HMS Scholarly Articles by Title
Now showing items 12062-12081 of 17922
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Optimal management of hereditary hemorrhagic telangiectasia
(Dove Medical Press, 2014)Hereditary hemorrhagic telangiectasia (HHT), also known by the eponym Osler–Weber–Rendu syndrome, is a group of related disorders inherited in an autosomal dominant fashion and characterized by the development of arteriovenous ... -
Optimal policy for value-based decision-making
(Nature Publishing Group, 2016)For decades now, normative theories of perceptual decisions, and their implementation as drift diffusion models, have driven and significantly improved our understanding of human and animal behaviour and the underlying ... -
Optimal Workloop Energetics of Muscle-Actuated Systems: An Impedance Matching View
(Public Library of Science, 2010)Integrative approaches to studying the coupled dynamics of skeletal muscles with their loads while under neural control have focused largely on questions pertaining to the postural and dynamical stability of animals and ... -
Optimism and the Socioeconomic Status Gradient in Adolescent Adiposity
(Elsevier BV, 2011)Purpose: To assess if dispositional optimism is associated with adiposity and explore if dispositional optimism mediates the relationship between parent education and adiposity (BMI z score). Methods: Multivariable regression ... -
Optimization and control in bacterial Lag phase
(BioMed Central, 2013)The lag phase of bacterial growth is important from a medical and food safety perspective, but difficult to study due to the low density and metabolic rate of cells. A new study by Alon and colleagues reveals that the gene ... -
An optimization formulation for characterization of pulsatile cortisol secretion
(Frontiers Media S.A., 2015)Cortisol is released to relay information to cells to regulate metabolism and reaction to stress and inflammation. In particular, cortisol is released in the form of pulsatile signals. This low-energy method of signaling ... -
Optimization of a Small Tropomyosin-Related Kinase B (TrkB) Agonist 7,8-Dihydroxyflavone Active in Mouse Models of Depression
(American Chemical Society (ACS), 2012)Structure–activity relationship study shows that the catechol group in 7,8-dihdyroxyflavone, a selective small TrkB receptor agonist, is critical for agonistic activity. To improve the poor pharmacokinetic profiles intrinsic ... -
Optimization of an Image-Guided Laser-Induced Choroidal Neovascularization Model in Mice
(Public Library of Science, 2015)The mouse model of laser-induced choroidal neovascularization (CNV) has been used in studies of the exudative form of age-related macular degeneration using both the conventional slit lamp and a new image-guided laser ... -
Optimization of Genome Engineering Approaches with the CRISPR/Cas9 System
(Public Library of Science, 2014)Designer nucleases such as TALENS and Cas9 have opened new opportunities to scarlessly edit the mammalian genome. Here we explored several parameters that influence Cas9-mediated scarless genome editing efficiency in murine ... -
Optimization of scarless human stem cell genome editing
(Oxford University Press, 2013)Efficient strategies for precise genome editing in human-induced pluripotent cells (hiPSCs) will enable sophisticated genome engineering for research and clinical purposes. The development of programmable sequence-specific ... -
Optimization of Storage Temperature for Cultured ARPE-19 Cells
(Hindawi Publishing Corporation, 2013)Purpose. The establishment of future retinal pigment epithelium (RPE) replacement therapy is partly dependent on the availability of tissue-engineered RPE cells, which may be enhanced by the development of suitable storage ... -
Optimized cell transplantation using adult rag2 mutant zebrafish
(2014)Cell transplantation into adult zebrafish has lagged behind mouse due to the lack of immune compromised models. Here, we have created homozygous rag2E450fs mutant zebrafish that have reduced numbers of functional T and B ... -
Optimized Gene Editing Technology for Drosophila melanogaster Using Germ Line-Specific Cas9
(National Academy of Sciences, 2013-11-19)The ability to engineer genomes in a specific, systematic, and cost- effective way is critical for functional genomic studies. Recent advances using the CRISPR-associated single-guide RNA system (Cas9/sgRNA) illustrate the ... -
Optimized Near-IR fluorescent agents for in vivo imaging of Btk expression
(American Chemical Society, 2015)Bruton's tyrosine kinase (Btk) is intricately involved in anti-apoptotic signaling pathways in cancer and in regulating innate immune response. A number of Btk inhibitors are in development for use in treating B-cell ... -
Optimized Strategy for in Vivo Cas9-Activation in Drosophila
(National Academy of Sciences, 2017-08-29)While several large-scale resources are available for in vivo loss-of-function studies in Drosophila, an analogous resource for overexpressing genes from their endogenous loci does not exist. We describe a strategy for ... -
Optimizing Copy Number Variation Analysis Using Genome-wide Short Sequence Oligonucleotide Arrays
(Oxford University Press, 2010)The detection of copy number variants (CNV) by array-based platforms provides valuable insight into understanding human diversity. However, suboptimal study design and data processing negatively affect CNV assessment. We ... -
Optimizing Network Connectivity for Mobile Health Technologies in sub-Saharan Africa
(Public Library of Science, 2012)Background: Mobile health (mHealth) technologies hold incredible promise to improve healthcare delivery in resource-limited settings. Network reliability across large catchment areas can be a major challenge. We performed ... -
Optimizing parameters of an open-source airway segmentation algorithm using different CT images
(BioMed Central, 2015)Background: Computed tomography (CT) helps physicians locate and diagnose pathological conditions. In some conditions, having an airway segmentation method which facilitates reconstruction of the airway from chest CT images ... -
Optimizing Partner Notification Programs for Men Who Have Sex with Men: Factorial Survey Results from South China
(Public Library of Science, 2016)Background: Syphilis is prevalent among men who have sex with men (MSM) in China. Syphilis partner notification (PN) programs targeting MSM has been considered as one of effective strategies to prevention and control of ...