Browsing HMS Scholarly Articles by Title

Now showing items 12102-12121 of 17922

    • Oral N-Acetyl-Cysteine Attenuates Loss of Dopaminergic Terminals in α-Synuclein Overexpressing Mice 

      Clark, Joanne; Clore, Elizabeth L.; Zheng, Kangni; Adame, Anthony; Masliah, Eliezer; Simon, David K. (Public Library of Science, 2010)
      Levels of glutathione are lower in the substantia nigra (SN) early in Parkinson's disease (PD) and this may contribute to mitochondrial dysfunction and oxidative stress. Oxidative stress may increase the accumulation of ...

    • Oral tongue cancer gene expression profiling: Identification of novel potential prognosticators by oligonucleotide microarray analysis 

      Estilo, Cherry L; O-charoenrat, Pornchai; Talbot, Simon George; Socci, Nicholas D; Carlson, Diane L; Ghossein, Ronald; Williams, Tijaana; Yonekawa, Yoshihiro; Ramanathan, Yegnanarayana; Boyle, Jay O; Kraus, Dennis H; Patel, Snehal; Shaha, Ashok R; Wong, Richard J; Huryn, Joseph M; Shah, Jatin P; Singh, Bhuvanesh (Springer Nature, 2009)
      Background: The present study is aimed at identifying potential candidate genes as prognostic markers in human oral tongue squamous cell carcinoma (SCC) by large scale gene expression profiling. Methods: The gene expression ...

    • Orbitofrontal volume deficit in schizophrenia and thought disorder 

      Nakamura, M.; Nestor, Paul Gerard; Levitt, James Jonathan; Cohen, Adam; Kawashima, T.; Shenton, Martha Elizabeth; McCarley, Robert William (Oxford University Press (OUP), 2008)
      Orbitofrontal Cortex (OFC) structural abnormality in schizophrenia has not been well characterized, probably due to marked anatomical variability and lack of consistent definitions. We previously reported OFC sulcogyral ...

    • Orchestrated experience-driven Arc/Arg3.1 responses are disrupted in a mouse model of Alzheimer’s disease 

      Rudinskiy, Nikita; Hawkes, Jonathan M.; Betensky, Rebecca Aubrey; Eguchi, Megumi; Yamaguchi, Shun; Spires-Jones, Tara L.; Hyman, Bradley Theodore (2012)
      Experience-induced expression of immediate-early gene Arc/Arg3.1 is known to play a pivotal role in the consolidation of memory. Here we use in-vivo longitudinal multiphoton imaging to show orchestrated activity-dependent ...

    • Order without Design 

      Kurakin, Alexei (BioMed Central, 2010)
      Experimental reality in molecular and cell biology, as revealed by advanced research technologies and methods, is manifestly inconsistent with the design perspective on the cell, thus creating an apparent paradox: where ...

    • Order-Disorder Interface Characterization Reveals Critical Factors for Disease and Drug Targets 

      Kallenbach, Jonah; Hsu, Wei-Lun; Dunker, A. Keith; Alterovitz, Gil (American Medical Informatics Association, 2013)
      Signal transduction pathways are of critical importance in disease and regulation of cellular functions. Proteins that do not fold to a state of stable tertiary structure, known as intrinsically disordered proteins, are ...

    • An organic jelly made fractal logic gate with an infinite truth table 

      Ghosh, Subrata; Fujita, Daisuke; Bandyopadhyay, Anirban (Nature Publishing Group, 2015)
      Widely varying logic gates invented over a century are all finite. As data deluge problem looms large on the information processing and communication industry, the thrust to explore radical concepts is increasing rapidly. ...

    • Organization of high-level visual cortex in human infants 

      Deen, Ben; Richardson, Hilary; Dilks, Daniel D.; Takahashi, Atsushi; Keil, Boris; Wald, Lawrence L.; Kanwisher, Nancy; Saxe, Rebecca (Nature Publishing Group, 2017)
      How much of the structure of the human mind and brain is already specified at birth, and how much arises from experience? In this article, we consider the test case of extrastriate visual cortex, where a highly systematic ...

    • Organizational characteristics of HIV/syphilis testing services for men who have sex with men in South China: a social entrepreneurship analysis and implications for creating sustainable service models 

      Tucker, Joseph D; Muessig, Kathryn E; Cui, Rosa; Bien, Cedric H; Lo, Elaine J; Lee, Ramon; Wang, Kaidi; Han, Larry; Liu, Feng-Ying; Yang, Li-Gang; Yang, Bin; Larson, Heidi; Peeling, Rosanna W (BioMed Central, 2014)
      Background: UNAIDS has called for greater HIV/syphilis testing worldwide just as local HIV/syphilis testing programs are cut or altered. New models are needed to make HIV/syphilis testing services sustainable while retaining ...

    • Organizational culture in cardiovascular care in Chinese hospitals: a descriptive cross-sectional study 

      Yin, Emily S.; Downing, Nicholas S.; Li, Xi; Singer, Sara J.; Curry, Leslie A.; Li, Jing; Krumholz, Harlan M.; Jiang, Lixin (BioMed Central, 2015)
      Background: Organizational learning, the process by which a group changes its behavior in response to newly acquired knowledge, is critical to outstanding organizational performance. In hospitals, strong organizational ...

    • Organized Skin Structure Is Regenerated In Vivo from Collagen-GAG Matrices Seeded with Autologous Keratinocytes 

      Compton, Carolyn C.; Butler, Charles E.; Yannas, Ioannis V.; Warland, Gretchen; Orgill, Dennis Paul (Nature Publishing Group, 1998)
      A well-characterized collagen-glycosaminoglycan matrix (CGM) that has been shown to function as a dermal analog was seeded with freshly disaggregated autologous keratinocytes and applied to full-thickness wounds in a porcine ...

    • Organochlorine exposures influence on breast cancer risk and survival according to estrogen receptor status: a Danish cohort-nested case-control study 

      Høyer, Annette P; Jørgensen, Torben; Rank, Fritz; Grandjean, Philippe (Springer Nature, 2001)
      Background The relationship between breast cancer and organochlorine exposure is controversial and complex. As estrogen receptor positive and negative breast cancer may represent different entities of the disease, this ...

    • Organotypic Culture of Physiologically Functional Adult Mammalian Retinas 

      Koizumi, Amane; Zeck, Günther; Ben, Yixin; Masland, Richard Harry; Jakobs, Tatjana Claudia (Public Library of Science, 2007)
      Background: The adult mammalian retina is an important model in research on the central nervous system. Many experiments require the combined use of genetic manipulation, imaging, and electrophysiological recording, which ...

    • Orientation-Specific Joining of AID-initiated DNA Breaks Promotes Antibody Class Switching 

      Dong, Junchao; Panchakshari, Rohit A.; Zhang, Tingting; Zhang, Yu; Hu, Jiazhi; Volpi, Sabrina A.; Meyers, Robin M.; Ho, Yu-Jui; Du, Zhou; Robbiani, Davide F.; Meng, Feilong; Gostissa, Monica; Nussenzweig, Michel C.; Manis, John P.; Alt, Frederick W. (2015)
      During B cell development, RAG endonuclease cleaves immunoglobulin heavy chain (IgH) V, D, and J gene segments and orchestrates their fusion as deletional events that assemble a V(D)J exon in the same transcriptional ...

    • Orientation-Specificity of Adaptation: Isotropic Adaptation Is Purely Monocular 

      Cass, John; Johnson, Ameika; Bex, Peter; Alais, David (Public Library of Science, 2012)
      Numerous studies have found that prolonged exposure to grating stimuli reduces sensitivity to subsequently presented gratings, most evidently when the orientations of the adapting and test patterns are similar. The rate ...

    • Origins of Intraoperative MRI 

      Mislow, John M.K.; Golby, Alexandra Jacqueline; Black, Peter M. (Elsevier BV, 2010)
      Neurosurgical diagnosis and intervention has evolved through improved neuroimaging, allowing better visualization of anatomy and pathology. This article discusses the various systems that have been designed over the last ...

    • Origins of Portal Hypertension in Nonalcoholic Fatty Liver Disease 

      Baffy, Gyorgy (Springer Nature, 2018)
      Nonalcoholic fatty liver disease (NAFLD) advanced to cirrhosis is often complicated by clinically significant portal hypertension, which is primarily caused by increased intrahepatic vascular resistance. Liver fibrosis ...

    • Origins of tumor-associated macrophages and neutrophils 

      Cortez-Retamozo, Virna; Etzrodt, Martin; Newton, Andita; Rauch, Philipp J.; Chudnovskiy, Aleksey; Berger, Cedric; Ryan, Russell H.; Iwamoto, Yoshiko; Marinelli, Brett; Gorbatov, Rostic; Forghani, Reza; Novobrantseva, Tatiana I.; Koteliansky, Victor; Figueiredo, Jose-Luiz; Chen, John W.; Anderson, Daniel G.; Nahrendorf, Matthias; Swirski, Filip K.; Weissleder, Ralph; Pittet, Mikael J. (National Academy of Sciences, 2012)
      Tumor-associated macrophages (TAMs) and tumor-associated neutrophils (TANs) can control cancer growth and exist in almost all solid neoplasms. The cells are known to descend from immature monocytic and granulocytic cells, ...

    • Origins, Actions and Dynamic Expression Patterns of the Neuropeptide VGF in Rat Peripheral and Central Sensory Neurones Following Peripheral Nerve Injury 

      Moss, Andrew; Ingram, Rachel; Koch, Stephanie; Theodorou, Andria; Low, Lucie; Baccei, Mark; Hathway, Gareth J; Salton, Stephen R; Fitzgerald, Maria; Costigan, Michael (BioMed Central, 2008)
      Background: The role of the neurotrophin regulated polypeptide, VGF, has been investigated in a rat spared injury model of neuropathic pain. This peptide has been shown to be associated with synaptic strengthening and ...

    • Ornithine Decarboxylase Antizyme Induces Hypomethylation of Genome DNA and Histone H3 Lysine 9 Dimethylation (H3K9me2) in Human Oral Cancer Cell Line 

      Yamamoto, Daisuke; Shima, Kaori; Matsuo, Kou; Nishioka, Takashi; Chen, Chang-Yan; Hu, Guo-fu; Sasaki, Akira; Tsuji, Takanori (Public Library of Science, 2010)
      Background: Methylation of CpG islands of genome DNA and lysine residues of histone H3 and H4 tails regulates gene transcription. Inhibition of polyamine synthesis by ornithine decarboxylase antizyme-1 (OAZ) in human oral ...