Browsing HMS Scholarly Articles by Title

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    • Parcellating Cortical Functional Networks in Individuals 

      Wang, Danhong; Buckner, Randy L.; Fox, Michael D.; Holt, Daphne J.; Holmes, Avram J.; Stoecklein, Sophia; Langs, Georg; Pan, Ruiqi; Qian, Tianyi; Li, Kuncheng; Baker, Justin T.; Stufflebeam, Steven M.; Wang, Kai; Wang, Xiaomin; Hong, Bo; Liu, Hesheng (2015)
      The capacity to identify the unique functional architecture of an individual’s brain is a critical step towards personalized medicine and understanding the neural basis of variations in human cognition and behavior. Here, ...

    • Parcs Is a Dual Regulator of Cell Proliferation and Apaf-1 Function 

      Sanchez-Olea, Roberto; Ortiz, Sara; Barreto, Odmara; Yang, Qing; Xu, Chi-jie; Zhu, Hong; Yuan, Junying (American Society for Biochemistry and Molecular Biology, 2008)
      Here we identify a novel protein, named Parcs for pro-apoptotic protein required for cell survival, that is involved in both cell cycle progression and apoptosis. Parcs interacted with Apaf-1 by binding to the oligomerization ...

    • Parent Preferences for Health Outcomes Associated with Autism Spectrum Disorders 

      Lavelle, Tara; Weinstein, Milton Charles; Newhouse, Joseph Paul; Munir, Kerim Mehmet; Kuhlthau, Karen Alice; Prosser, Lisa Alison (Springer Science and Business Media LLC, 2019-03-21)
      Background: Few studies have used preference-based quality of life measures to assess how autism spectrum disorders (ASD) affect children and their parents, and none have examined variation in outcomes by parent-reported ...

    • Parent-of-Origin Effects of the APOB Gene on Adiposity in Young Adults 

      Hochner, Hagit; Allard, Catherine; Granot-Hershkovitz, Einat; Chen, Jinbo; Sitlani, Colleen M.; Sazdovska, Sandra; Lumley, Thomas; McKnight, Barbara; Rice, Kenneth; Enquobahrie, Daniel A.; Meigs, James B.; Kwok, Pui; Hivert, Marie-France; Borecki, Ingrid B.; Gomez, Felicia; Wang, Ting; van Duijn, Cornelia; Amin, Najaf; Rotter, Jerome I.; Stamatoyannopoulos, John; Meiner, Vardiella; Manor, Orly; Dupuis, Josée; Friedlander, Yechiel; Siscovick, David S. (Public Library of Science, 2015)
      Loci identified in genome-wide association studies (GWAS) of cardio-metabolic traits account for a small proportion of the traits' heritability. To date, most association studies have not considered parent-of-origin effects ...

    • Parent-of-origin specific allelic associations among 106 genomic loci for age at menarche 

      Perry, John RB; Day, Felix; Elks, Cathy E; Sulem, Patrick; Thompson, Deborah J; Ferreira, Teresa; He, Chunyan; Chasman, Daniel I; Esko, Tõnu; Thorleifsson, Gudmar; Albrecht, Eva; Ang, Wei Q; Corre, Tanguy; Cousminer, Diana L; Feenstra, Bjarke; Franceschini, Nora; Ganna, Andrea; Johnson, Andrew D; Kjellqvist, Sanela; Lunetta, Kathryn L; McMahon, George; Nolte, Ilja M; Paternoster, Lavinia; Porcu, Eleonora; Smith, Albert V; Stolk, Lisette; Teumer, Alexander; Tšernikova, Natalia; Tikkanen, Emmi; Ulivi, Sheila; Wagner, Erin K; Amin, Najaf; Bierut, Laura J; Byrne, Enda M; Hottenga, Jouke-Jan; Koller, Daniel L; Mangino, Massimo; Pers, Tune H; Yerges-Armstrong, Laura M; Zhao, Jing Hua; Andrulis, Irene L; Anton-Culver, Hoda; Atsma, Femke; Bandinelli, Stefania; Beckmann, Matthias W; Benitez, Javier; Blomqvist, Carl; Bojesen, Stig E; Bolla, Manjeet K; Bonanni, Bernardo; Brauch, Hiltrud; Brenner, Hermann; Buring, Julie E; Chang-Claude, Jenny; Chanock, Stephen; Chen, Jinhui; Chenevix-Trench, Georgia; Collée, J. Margriet; Couch, Fergus J; Couper, David; Coveillo, Andrea D; Cox, Angela; Czene, Kamila; D’adamo, Adamo Pio; Smith, George Davey; De Vivo, Immaculata; Demerath, Ellen W; Dennis, Joe; Devilee, Peter; Dieffenbach, Aida K; Dunning, Alison M; Eiriksdottir, Gudny; Eriksson, Johan G; Fasching, Peter A; Ferrucci, Luigi; Flesch-Janys, Dieter; Flyger, Henrik; Foroud, Tatiana; Franke, Lude; Garcia, Melissa E; García-Closas, Montserrat; Geller, Frank; de Geus, Eco EJ; Giles, Graham G; Gudbjartsson, Daniel F; Gudnason, Vilmundur; Guénel, Pascal; Guo, Suiqun; Hall, Per; Hamann, Ute; Haring, Robin; Hartman, Catharina A; Heath, Andrew C; Hofman, Albert; Hooning, Maartje J; Hopper, John L; Hu, Frank B; Hunter, David J; Karasik, David; Kiel, Douglas P; Knight, Julia A; Kosma, Veli-Matti; Kutalik, Zoltan; Lai, Sandra; Lambrechts, Diether; Lindblom, Annika; Mägi, Reedik; Magnusson, Patrik K; Mannermaa, Arto; Martin, Nicholas G; Masson, Gisli; McArdle, Patrick F; McArdle, Wendy L; Melbye, Mads; Michailidou, Kyriaki; Mihailov, Evelin; Milani, Lili; Milne, Roger L; Nevanlinna, Heli; Neven, Patrick; Nohr, Ellen A; Oldehinkel, Albertine J; Oostra, Ben A; Palotie, Aarno; Peacock, Munro; Pedersen, Nancy L; Peterlongo, Paolo; Peto, Julian; Pharoah, Paul DP; Postma, Dirkje S; Pouta, Anneli; Pylkäs, Katri; Radice, Paolo; Ring, Susan; Rivadeneira, Fernando; Robino, Antonietta; Rose, Lynda M; Rudolph, Anja; Salomaa, Veikko; Sanna, Serena; Schlessinger, David; Schmidt, Marjanka K; Southey, Mellissa C; Sovio, Ulla; Stampfer, Meir J; Stöckl, Doris; Storniolo, Anna M; Timpson, Nicholas J; Tyrer, Jonathan; Visser, Jenny A; Vollenweider, Peter; Völzke, Henry; Waeber, Gerard; Waldenberger, Melanie; Wallaschofski, Henri; Wang, Qin; Willemsen, Gonneke; Winqvist, Robert; Wolffenbuttel, Bruce HR; Wright, Margaret J; Boomsma, Dorret I; Econs, Michael J; Khaw, Kay-Tee; Loos, Ruth JF; McCarthy, Mark I; Montgomery, Grant W; Rice, John P; Streeten, Elizabeth A; Thorsteinsdottir, Unnur; van Duijn, Cornelia M; Alizadeh, Behrooz Z; Bergmann, Sven; Boerwinkle, Eric; Boyd, Heather A; Crisponi, Laura; Gasparini, Paolo; Gieger, Christian; Harris, Tamara B; Ingelsson, Erik; Järvelin, Marjo-Riitta; Kraft, Peter; Lawlor, Debbie; Metspalu, Andres; Pennell, Craig E; Ridker, Paul M; Snieder, Harold; Sørensen, Thorkild IA; Spector, Tim D; Strachan, David P; Uitterlinden, André G; Wareham, Nicholas J; Widen, Elisabeth; Zygmunt, Marek; Murray, Anna; Easton, Douglas F; Stefansson, Kari; Murabito, Joanne M; Ong, Ken K (2014)
      Age at menarche is a marker of timing of puberty in females. It varies widely between individuals, is a heritable trait and is associated with risks for obesity, type 2 diabetes, cardiovascular disease, breast cancer and ...

    • Parent-Rated Behavior Problems Associated with Overweight Before and After Controlling for Sleep Disordered Breathing 

      Mulvaney, Shelagh A.; Kaemingk, Kristine L.; Goodwin, James L.; Quan, Stuart (Springer Science and Business Media LLC, 2006-12-14)
      Background Researchers and clinicians are seeking to develop efficacious behavioral interventions to treat overweight children; however, few studies have documented the behavioral correlates of overweight children in ...

    • Parent-Rated Behavior Problems Associated With Overweight Before and After Controlling for Sleep Disordered Breathing 

      Mulvaney, Shelagh A; Kaemingk, Kristine L; Goodwin, James L; Quan, Stuart (Springer Science and Business Media LLC, 2006-12-14)
      Background Researchers and clinicians are seeking to develop efficacious behavioral interventions to treat overweight children; however, few studies have documented the behavioral correlates of overweight children in ...

    • Parental smoking during pregnancy and risk of overweight and obesity in the daughter 

      Harris, Holly R.; Willett, Walter C.; Michels, Karin B. (2013)
      Objective: Emerging evidence suggests that prenatal exposures may affect long-term health outcomes. In utero exposure to smoking is associated with an increased risk of overweight and obesity in children and adolescents. ...

    • Parents and adolescents preferences for asthma control: a best-worst scaling choice experiment using an orthogonal main effects design 

      Ungar, Wendy J.; Hadioonzadeh, Anahita; Najafzadeh, Mehdi; Tsao, Nicole W.; Dell, Sharon; Lynd, Larry D. (BioMed Central, 2015)
      Background: The preferences of parents and children with asthma influence their ability to manage a child’s asthma and achieve good control. Potential differences between parents and adolescents with respect to specific ...

    • Parents’ Disclosure of Their HIV Infection to Their Children in the Context of the Family 

      Kennedy, David P.; Cowgill, Burton O.; Bogart, Laura M; Corona, Rosalie; Ryan, Gery W.; Murphy, Debra A.; Nguyen, Theresa; Schuster, Mark A. (Springer US, 2010)
      We interviewed 33 HIV-infected parents from the HIV Cost and Services Utilization Study (HCSUS), 27 of their minor children, 19 adult children, and 15 caregivers about the process of children learning that their parents ...

    • Parents’ perception of child and adolescent mental health problems and their choice of treatment option in southwest Ethiopia 

      Abera, Mubarek; Robbins, Jeffrey M.; Tesfaye, Markos (BioMed Central, 2015)
      Background: Parents’ perception and awareness about psychiatric illness in children and adolescents is an important determinant of early detection and treatment seeking for the condition. However, there has been limited ...

    • Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation 

      Dettmer, Ulf; Newman, Andrew J.; Soldner, Frank; Luth, Eric S.; Kim, Nora C.; von Saucken, Victoria E.; Sanderson, John B.; Jaenisch, Rudolf; Bartels, Tim; Selkoe, Dennis (Nature Pub. Group, 2015)
      β-Sheet-rich α-synuclein (αS) aggregates characterize Parkinson's disease (PD). αS was long believed to be a natively unfolded monomer, but recent work suggests it also occurs in α-helix-rich tetramers. Crosslinking traps ...

    • ParP prevents dissociation of CheA from chemotactic signaling arrays and tethers them to a polar anchor 

      Ringgaard, Simon; Zepeda-Rivera, Martha; Wu, Xiaoji; Schirner, Kathrin; Davis, Brigid M.; Waldor, Matthew K. (National Academy of Sciences, 2014)
      Bacterial chemotaxis proteins are organized into ordered arrays. In peritrichous organisms, such as Escherichia coli, stochastic assembly processes are thought to account for the placement of chemotaxis arrays, which are ...

    • Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner 

      Calvo, Jennifer A.; Allocca, Mariacarmela; Fake, Kimberly R.; Muthupalani, Sureshkumar; Corrigan, Joshua J.; Bronson, Roderick T.; Samson, Leona D. (Impact Journals LLC, 2016)
      Nephrotoxicity is a common toxic side-effect of chemotherapeutic alkylating agents. Although the base excision repair (BER) pathway is essential in repairing DNA alkylation damage, under certain conditions the initiation ...

    • PARP3 affects the relative contribution of homologous recombination and nonhomologous end-joining pathways 

      Beck, Carole; Boehler, Christian; Guirouilh Barbat, Josée; Bonnet, Marie-Elise; Illuzzi, Giuditta; Ronde, Philippe; Gauthier, Laurent R.; Magroun, Najat; Rajendran, Anbazhagan; Lopez, Bernard S.; Scully, Ralph; Boussin, François D.; Schreiber, Valérie; Dantzer, Françoise (Oxford University Press, 2014)
      The repair of toxic double-strand breaks (DSB) is critical for the maintenance of genome integrity. The major mechanisms that cope with DSB are: homologous recombination (HR) and classical or alternative nonhomologous end ...

    • PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation 

      Iwata, Hiroshi; Goettsch, Claudia; Sharma, Amitabh; Ricchiuto, Piero; Goh, Wilson Wen Bin; Halu, Arda; Yamada, Iwao; Yoshida, Hideo; Hara, Takuya; Wei, Mei; Inoue, Noriyuki; Fukuda, Daiju; Mojcher, Alexander; Mattson, Peter C.; Barabási, Albert-László; Boothby, Mark; Aikawa, Elena; Singh, Sasha A.; Aikawa, Masanori (Nature Publishing Group, 2016)
      Despite the global impact of macrophage activation in vascular disease, the underlying mechanisms remain obscure. Here we show, with global proteomic analysis of macrophage cell lines treated with either IFNγ or IL-4, that ...

    • Parsing the construct of maternal insensitivity: distinct longitudinal pathways associated with early maternal withdrawal 

      Lyons-Ruth, Karlen; Bureau, Jean-Francois; Easterbrooks, M. Ann; Obsuth, Ingrid; Hennighausen, Kate; Vulliez-Coady, Lauriane (Informa UK Limited, 2013)
      The current paper expands on Ainsworth’s seminal construct of maternal sensitivity by exploring the developmental pathways associated with one particular form of insensitivity: maternal withdrawal. Drawing on longitudinal ...

    • Participants' Experiences of Being Debriefed to Placebo Allocation in a Clinical Trial 

      Bishop, F. L.; Jacobson, Eric Emil; Shaw, J.; Kaptchuk, Ted Jack (SAGE Publications, 2012)
      Participants in placebo-controlled clinical trials give informed consent to be randomized to verum or placebo. However, researchers rarely tell participants which treatment they actually received. We interviewed four ...

    • Participation in Activity and Risk for Incident Delirium 

      Yang, Frances M.; Inouye, Sharon; Fearing, Michael A.; Kiely, Dan K.; Marcantonio, Edward Ralph; Jones, Richard Norman (Wiley-Blackwell, 2008)

    • Participation in physical activity in patients 1–4 years post total joint replacement in the Dominican Republic 

      Elman, Scott A; Dong, Yan; Stenquist, Derek S; Ghazinouri, Roya; Alcantara, Luis; Collins, Jamie E; Beagan, Carolyn; Thornhill, Thomas S; Katz, Jeffrey N (BioMed Central, 2014)
      Background: To address both the growing burden of joint disease and the gaps in medical access in developing nations, medical relief organizations have begun to launch programs to perform total joint replacement (TJR) on ...