Browsing HMS Scholarly Articles by Title
Now showing items 12542-12561 of 17922
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Periodontal bone loss and risk of epithelial ovarian cancer
(Springer Nature, 2015)PURPOSE: Periodontitis, a chronic inflammatory response to pathogenic bacteria in the oral microbiome, is common among adults. It is associated with several medical conditions, including cardiovascular diseases, and ... -
Perioperative and long-term outcomes of liver resection for hepatitis B virus-related hepatocellular carcinoma without versus with hepatic inflow occlusion: study protocol for a prospective randomized controlled trial
(BioMed Central, 2016)Background: The high prevalence of hepatitis B virus (HBV) imposes a huge burden of hepatocellular carcinoma (HCC) in Asia. Surgical resection remains an important therapeutic strategy for HCC. Hepatic inflow occlusion, ... -
Perioperative Buprenorphine Continuous Maintenance and Administration Simultaneous With Full Opioid Agonist; Patient Priority at the Interface Between Medical Disciplines
(Physicians Postgraduate Press, Inc, 2020-01-07)Buprenorphine is a partial-agonist opioid that is prescribed as a Medication-assisted treatment (MAT) for opioid use disorder (OUD). Buprenorphine is also a potent analgesic with high opioid-receptor (OR) affinity and ... -
Perioperative genomics: coming soon to (operating) theatres near you
(Springer Nature, 2015) -
Perioperative sleep apnea: a real problem or did we invent a new disease?
(F1000Research, 2016)Depending on the subpopulation, obstructive sleep apnea (OSA) can affect more than 75% of surgical patients. An increasing body of evidence supports the association between OSA and perioperative complications, but some ... -
Peripapillary Retinal Thickness Maps in the Evaluation of Glaucoma Patients: A Novel Concept
(International Scholarly Research Network, 2011)Purpose. To show how peripapillary spectral domain optical coherence tomography (SDOCT) retinal thickness (RT) maps can complement retinal nerve fiber layer (RNFL) thickness maps in the evaluation of glaucoma patients. ... -
Peripheral and central effects of γ-secretase inhibition by semagacestat in Alzheimer’s disease
(BioMed Central, 2015)Introduction: The negative efficacy study examining the γ-secretase inhibitor semagacestat in mild to moderate Alzheimer’s disease (AD) included a number of biomarkers of the disease as well as safety outcomes. We analyzed ... -
Peripheral Nervous System Manifestations in a Sandhoff Disease Mouse Model: Nerve Conduction, Myelin Structure, Lipid Analysis
(BioMed Central, 2007)Background: Sandhoff disease is an inherited lysosomal storage disease caused by a mutation in the gene for the β-subunit (Hexb gene) of β-hexosaminidase A (αβ) and B (ββ). The β-subunit together with the GM2 activator ... -
Peripheral Surgical Wounding and Age-Dependent Neuroinflammation in Mice
(Public Library of Science, 2014)Post-operative cognitive dysfunction is associated with morbidity and mortality. However, its neuropathogenesis remains largely to be determined. Neuroinflammation and accumulation of β-amyloid (Aβ) have been reported to ... -
Peritoneal Dissemination Complicating Morcellation of Uterine Mesenchymal Neoplasms
(Public Library of Science, 2012)Background: Power morcellation has become a common technique for the minimally invasive resection of uterine leiomyomas. This technique is associated with dissemination of cellular material throughout the peritoneum. When ... -
Peritoneal Tuberculosis in a Pregnant Woman from Haiti, United States
(U.S. National Center for Infectious Diseases, 2013) -
Periventricular Heterotopia: Shuttling of Proteins through Vesicles and Actin in Cortical Development and Disease
(Hindawi Publishing Corporation, 2012)During cortical development, proliferating neural progenitors exhibit polarized apical and basolateral membranes that are maintained by tightly controlled and membrane-specific vesicular trafficking pathways. Disruption ... -
Permeabilization of the Blood-Brain Barrier via Mucosal Engrafting: Implications for Drug Delivery to the Brain
(Public Library of Science, 2013)Utilization of neuropharmaceuticals for central nervous system(CNS) disease is highly limited due to the blood-brain barrier(BBB) which restricts molecules larger than 500Da from reaching the CNS. The development of a ... -
Peroxidase Activity of Cyclooxygenase-2 (COX-2) Cross-links β-Amyloid (Aβ) and Generates Aβ-COX-2 Hetero-oligomers That Are Increased in Alzheimer's Disease
(American Society for Biochemistry & Molecular Biology (ASBMB), 2004-01-14)Oxidative stress is associated with the neuropathology of Alzheimer's disease. We have previously shown that human Abeta has the ability to reduce Fe(III) and Cu(II) and produce hydrogen peroxide coupled with these metals, ... -
Peroxisome Proliferator-activated Receptor γ Coactivator 1β (PGC-1β), A Novel PGC-1-related Transcription Coactivator Associated with Host Cell Factor
(American Society for Biochemistry and Molecular Biology, 2002) -
Peroxisomes are platforms for cytomegalovirus’ evasion from the cellular immune response
(Nature Publishing Group, 2016)The human cytomegalovirus developed distinct evasion mechanisms from the cellular antiviral response involving vMIA, a virally-encoded protein that is not only able to prevent cellular apoptosis but also to inhibit signalling ... -
Peroxisomes move by hitchhiking on early endosomes using the novel linker protein PxdA
(The Rockefeller University Press, 2016)Eukaryotic cells use microtubule-based intracellular transport for the delivery of many subcellular cargos, including organelles. The canonical view of organelle transport is that organelles directly recruit molecular ... -
PerR Confers Phagocytic Killing Resistance and Allows Pharyngeal Colonization by Group A Streptococcus
(Public Library of Science, 2008)The peroxide response transcriptional regulator, PerR, is thought to contribute to virulence of group A Streptococcus (GAS); however, the specific mechanism through which it enhances adaptation for survival in the human ... -
Persistence of Prolonged C-peptide Production in Type 1 Diabetes as Measured With an Ultrasensitive C-peptide Assay
(American Diabetes Association, 2012)Objective: To examine persistence of C-peptide production by ultrasensitive assay years after onset of type 1 diabetes and factors associated with preserving β-cell function. Research Design and Methods: Serum C-peptide ... -
Persistence Survey of Toxic Shock Syndrome Toxin-1 Producing Staphylococcus Aureus and Serum Antibodies to this Superantigen in Five Groups of Menstruating Women
(BioMed Central, 2010)Background: Menstrual Toxic Shock Syndrome (mTSS) is thought to be associated with the vaginal colonization with specific strains of Staphylococcus aureus TSST-1 in women who lack sufficient antibody titers to this toxin. ...