Browsing HMS Scholarly Articles by Title
Now showing items 12701-12720 of 17921
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Photochemical activation of TRPA1 channels in neurons and animals
(2013)Optogenetics is a powerful research tool because it enables high-resolution optical control of neuronal activity. However, current optogenetic approaches are limited to transgenic systems expressing microbial opsins and ... -
Photochemical Tissue Passivation Reduces Vein Graft Intimal Hyperplasia in a Swine Model of Arteriovenous Bypass Grafting
(John Wiley and Sons Inc., 2016)Background: Bypass grafting remains the standard of care for coronary artery disease and severe lower extremity ischemia. Efficacy is limited by poor long‐term venous graft patency secondary to intimal hyperplasia (IH) ... -
Photocleavable DNA barcode-antibody conjugates allow sensitive and multiplexed protein analysis in single cell
(American Chemical Society, 2012) -
Photodynamic activation as a molecular switch to promote osteoblast cell differentiation via AP-1 activation
(Nature Publishing Group, 2015)In photodynamic therapy (PDT), cells are impregnated with a photosensitizing agent that is activated by light irradiation, thereby photochemically generating reactive oxygen species (ROS). The amounts of ROS produced depends ... -
Photodynamic and Antibiotic Therapy Impair the Pathogenesis of Enterococcus faecium in a Whole Animal Insect Model
(Public Library of Science, 2013)Enterococcus faecium has emerged as one of the most important pathogens in healthcare-associated infections worldwide due to its intrinsic and acquired resistance to many antibiotics, including vancomycin. Antimicrobial ... -
Photodynamic Therapy Applications in Cancer, Infections and Cardiovascular Disease
(Tan Tao University, 2023-08-22)Photodynamic therapy (PDT) or light treatment is a procedure to treat certain types of diseases that uses a photosensitizer (PS) which upon light activation produces cytotoxic oxygen species destroying tumor cells. PDT is ... -
Photodynamic Therapy Can Induce a Protective Innate Immune Response against Murine Bacterial Arthritis via Neutrophil Accumulation
(Public Library of Science, 2012)Background: Local microbial infections induced by multiple-drug-resistant bacteria in the orthopedic field can be intractable, therefore development of new therapeutic modalities is needed. Photodynamic therapy (PDT) is a ... -
Photodynamic Therapy for Acinetobacter baumannii Burn Infections in Mice
(American Society for Microbiology, 2009)Multidrug-resistant Acinetobacter baumannii infections represent a growing problem, especially in traumatic wounds and burns suffered by military personnel injured in Middle Eastern conflicts. Effective treatment with ... -
Photodynamic Therapy of Orthotopic Prostate Cancer With Benzoporphyrin Derivative: Local Control and Distant Metastasis
(1998)This is the first report of photodynamic therapy (PDT) in an orthotopic prostate tumor model and shows that PDT combined with surgery (tumor bed sterilization) gave significant local control of the primary tumor and ... -
Photodynamic Therapy of Tumors Can Lead to Development of Systemic Antigen-Specific Immune Response
(Public Library of Science, 2010)Background: The mechanism by which the immune system can effectively recognize and destroy tumors is dependent on recognition of tumor antigens. The molecular identity of a number of these antigens has recently been ... -
Photodynamic therapy plus regulatory T-cell depletion produces immunity against a mouse tumour that expresses a self-antigen
(Nature Publishing Group, 2013)Background: Photodynamic therapy (PDT) can lead to development of antigen-specific immune response and PDT-mediated immunity can be potentiated by T regulatory cell (Treg) depletion. We investigated whether the combination ... -
Photographic but not line-drawn faces show early perceptual neural sensitivity to eye gaze direction
(Frontiers Media S.A., 2015)Our brains readily decode facial movements and changes in social attention, reflected in earlier and larger N170 event-related potentials (ERPs) to viewing gaze aversions vs. direct gaze in real faces (Puce et al., 2000). ... -
Photometric stereo endoscopy
(Society of Photo-Optical Instrumentation Engineers, 2013)Abstract. While color video endoscopy has enabled wide-field examination of the gastrointestinal tract, it often misses or incorrectly classifies lesions. Many of these missed lesions exhibit characteristic three-dimensional ... -
Photoprotective Effects of Cycloheterophyllin against UVA-Induced Damage and Oxidative Stress in Human Dermal Fibroblasts
(Public Library of Science, 2016)Ultraviolet (UV) radiation, particularly ultraviolet A (UVA), is known to play a major role in photoaging of the human skin. Many studies have demonstrated that UV exposure causes the skin cells to generate reactive oxygen ... -
Photoreceptor cell death and rescue in retinal detachment and degenerations
(Elsevier BV, 2013)Photoreceptor cell death is the ultimate cause of vision loss in various retinal disorders, including retinal detachment (RD). Photoreceptor cell death has been thought to occur mainly through apoptosis, which is the most ... -
Photoreceptor Rescue by an Abbreviated Human RPGR Gene in a Murine Model of X-linked Retinitis Pigmentosa
(2015)The X-linked RP3 gene codes for the ciliary protein RPGR and accounts for over 10% of inherited retinal degenerations. The critical RPGR-ORF15 splice variant contains a highly repetitive purine-rich linker region that ... -
Photoswitchable Nanoparticles for Triggered Tissue Penetration and Drug Delivery
(American Chemical Society, 2012)We report a novel nanoparticulate drug delivery system that undergoes reversible volume change from 150 to 40 nm upon phototriggering with UV light. The volume change of these monodisperse nanoparticles comprising spiropyran, ... -
PhyloGene server for identification and visualization of co-evolving proteins using normalized phylogenetic profiles
(Oxford University Press, 2015)Proteins that function in the same pathways, protein complexes or the same environmental conditions can show similar patterns of sequence conservation across phylogenetic clades. In species that no longer require a specific ... -
Phylogenetic Analyses and Characterization of RNase X25 from Drosophila melanogaster Suggest a Conserved Housekeeping Role and Additional Functions for RNase T2 Enzymes in Protostomes
(Public Library of Science, 2014)Ribonucleases belonging to the RNase T2 family are enzymes associated with the secretory pathway that are almost absolutely conserved in all eukaryotes. Studies in plants and vertebrates suggest they have an important ... -
Phylogenetic Analyses of Complete Mitochondrial Genome Sequences Suggest a Basal Divergence of the Enigmatic Rodent Anomalurus
(BioMed Central, 2007)Background: Phylogenetic relationships between Lagomorpha, Rodentia and Primates and their allies (Euarchontoglires) have long been debated. While it is now generally agreed that Rodentia constitutes a monophyletic ...