Browsing HMS Scholarly Articles by Title

Now showing items 12850-12869 of 17922

    • Plasmacytoma of the Clivus Presenting as Bilateral Sixth Nerve Palsy 

      Kalwani, Neil; Remenschneider, Aaron K.; Faquin, William; Ferry, Judith; Holbrook, Eric H. (Georg Thieme Verlag KG, 2015)
      Background and Importance Plasmacytomas are monoclonal proliferations of plasma cells that may arise within soft tissue or bone. The skull base is a rare site for plasmacytomas to occur, and few cases have been reported ...

    • Plasmodium falciparum gene expression measured directly from tissue during human infection 

      Van Tyne, Daria; Tan, Yan; Daily, Johanna P; Kamiza, Steve; Seydel, Karl; Taylor, Terrie; Mesirov, Jill P; Wirth, Dyann F; Milner, Danny A (BioMed Central, 2014)
      Background: During the latter half of the natural 48-h intraerythrocytic life cycle of human Plasmodium falciparum infection, parasites sequester deep in endothelium of tissues, away from the spleen and inaccessible to ...

    • Plastic Surgery Training Worldwide: Part 1. The United States and Europe 

      Kamali, Parisa; van Paridon, Maaike W.; Ibrahim, Ahmed M. S.; Paul, Marek A.; Winters, Henri A.; Martinot-Duquennoy, Veronique; Noah, Ernst Magnus; Pallua, Norbert; Lin, Samuel J. (Wolters Kluwer Health, 2016)
      Background: Major differences exist in residency training, and the structure and quality of residency programs differ between different countries and teaching centers. It is of vital importance that a better understanding ...

    • Plasticity in PYD assembly revealed by cryo-EM structure of the PYD filament of AIM2 

      Lu, Alvin; Li, Yang; Yin, Qian; Ruan, Jianbin; Yu, Xiong; Egelman, Edward; Wu, Hao (2015)
      Absent in melanoma 2 (AIM2) is an essential cytosolic double-stranded DNA receptor that assembles with the adaptor, apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC), and caspase-1 to ...

    • Plasticity of brain wave network interactions and evolution across physiologic states 

      Liu, Kang K. L.; Bartsch, Ronny P.; Lin, Aijing; Mantegna, Rosario N.; Ivanov, Plamen Ch. (Frontiers Media S.A., 2015)
      Neural plasticity transcends a range of spatio-temporal scales and serves as the basis of various brain activities and physiologic functions. At the microscopic level, it enables the emergence of brain waves with complex ...

    • Plasticity of face processing in infancy 

      Pascalis, O.; Scott, L. S.; Kelly, D. J.; Shannon, R. W.; Nicholson, Ellen Colton; Coleman, M.; Nelson, Charles A. (Proceedings of the National Academy of Sciences, 2005)
      Experience plays a crucial role for the normal development of many perceptual and cognitive functions, such as speech perception. For example, between 6 and 10 months of age, the infant's ability to discriminate among ...

    • Platelet actin nodules are podosome-like structures dependent on Wiskott–Aldrich syndrome protein and ARP2/3 complex 

      Poulter, Natalie S.; Pollitt, Alice Y.; Davies, Amy; Malinova, Dessislava; Nash, Gerard B.; Hannon, Mike J.; Pikramenou, Zoe; Rappoport, Joshua Z.; Hartwig, John H.; Owen, Dylan M.; Thrasher, Adrian J.; Watson, Stephen P.; Thomas, Steven G. (Nature Pub. Group, 2015)
      The actin nodule is a novel F-actin structure present in platelets during early spreading. However, only limited detail is known regarding nodule organization and function. Here we use electron microscopy, SIM and dSTORM ...

    • Platelet Granule Exocytosis: A Comparison with Chromaffin Cells 

      Fitch-Tewfik, Jennifer L.; Flaumenhaft, Robert (Frontiers Media S.A., 2013)
      The rapid secretion of bioactive amines from chromaffin cells constitutes an important component of the fight or flight response of mammals to stress. Platelets respond to stresses within the vasculature by rapidly secreting ...

    • Platelet-Associated CD40/CD154 Mediates Remote Tissue Damage after Mesenteric Ischemia/Reperfusion Injury 

      Lapchak, Peter H.; Ioannou, Antonis; Kannan, Lakshmi; Rani, Poonam; Dalle Lucca, Jurandir J.; Tsokos, George C. (Public Library of Science, 2012)
      Several innate and adaptive immune cell types participate in ischemia/reperfusion induced tissue injury. Amongst them, platelets have received little attention as contributors in the process of tissue damage after ischemia ...

    • Platelet-Derived Growth Factor Receptor β Is Critical for Zebrafish Intersegmental Vessel Formation 

      Wiens, Katie M.; Lee, Hyunju; Shimada, Hiroyuki; Metcalf, Anthony E.; Chao, Michael; Lien, Ching-Ling (Public Library of Science, 2010)
      Background: Platelet-derived growth factor receptor β (PDGFRβ) is a tyrosine kinase receptor known to affect vascular development. The zebrafish is an excellent model to study specific regulators of vascular development, ...

    • Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage 

      Kisucka, Janka; Butterfield, Catherine; Duda, Dan; Eichenberger, Sarah; Saffaripour, Simin; Ware, Jerry; Ruggeri, Zaverio; Jain, Rakesh; Folkman, Judah; Wagner, Denisa (National Academy of Sciences, 2006)
      Platelets contain both pro- and antiangiogenic factors, but their regulatory role in angiogenesis is poorly understood. Although previous studies showed that platelets stimulate angiogenesis in vitro, the role of platelets ...

    • Platelets Generated from Human Embryonic Stem Cells are Functional In Vitro and in the Microcirculation of Living Mice 

      Lu, Shi-Jiang; Li, Feng; Feng, Qiang; Kimbrel, Erin A; Hahm, Eunsil; Cho, Jaehyung; Lanza, Robert; Yin, Hong; Thon, Jonathan Noah; Wang, Wei; Italiano, Joseph E. (Nature Publishing Group, 2011)
      Platelets play an essential role in hemostasis and atherothrombosis. Owing to their short storage time, there is constant demand for this life-saving blood component. In this study, we report that it is feasible to generate ...

    • Platelets Recognize Brain-Specific Glycolipid Structures, Respond to Neurovascular Damage and Promote Neuroinflammation 

      Sotnikov, Ilya; Veremeyko, Tatyana; Starossom, Sarah Christin; Barteneva, Natalia; Weiner, Howard Lee; Ponomarev, Eugene D. (Public Library of Science, 2013)
      Platelets respond to vascular damage and contribute to inflammation, but their role in the neurodegenerative diseases is unknown. We found that the systemic administration of brain lipid rafts induced a massive platelet ...

    • Platform dependence of inference on gene-wise and gene-set involvement in human lung development 

      Bhattacharya, Soumyaroop; Metje, Stephanie; Gaedigk, Roger; Mariani, Thomas J; Leeder, J Steven; Du, Rose; Tantisira, Kelan; Carey, Vincent James; Kho, Alvin Thong-Juak; Klanderman, Barbara Jordan; Lazarus, Ross; Weiss, Scott Tillman (BioMed Central, 2009)
      Background: With the recent development of microarray technologies, the comparability of gene expression data obtained from different platforms poses an important problem. We evaluated two widely used platforms, Affymetrix ...

    • Platinum compounds for high-resolution in vivo cancer imaging 

      Miller, A.; Askevold, Bjorn; Yang, S.; Kohler, Rainer; Weissleder, Ralph (Wiley, 2014)
      Platinum(II) compounds, principally cisplatin and carboplatin, are commonly used front-line cancer therapeutics. Despite their widespread use and continued interest in the development of new derivatives, including ...

    • Play, Precariousness, and the Negotiation of Shared Meaning: A Developmental Research Perspective on Child Psychotherapy 

      Lyons-Ruth, Karlen (Routledge, 2006)
      Recent work in developmental psychology and primatology indicates that human infants are distinguished from other primates by the end of the 1st year by their awareness that others have subjective states like their own. ...

    • PLC-γ2 is Essential for Formation and Maintenance of Memory B Cells 

      Hikida, Masaki; Casola, Stefano; Takahashi, Noriko; Kaji, Tomohiro; Takemori, Toshitada; Rajewsky, Klaus; Kurosaki, Tomohiro (The Rockefeller University Press, 2009)
      Resting antigen-experienced memory B cells are thought to be responsible for the more rapid and robust antibody responses after antigen reencounter, which are the hallmark of memory humoral responses. The molecular basis ...

    • Pleiotropic and Sex-Specific Effects of Cancer GWAS SNPs on Melanoma Risk in the Population Architecture Using Genomics and Epidemiology (PAGE) Study 

      Kocarnik, Jonathan M.; Park, S. Lani; Han, Jiali; Dumitrescu, Logan; Cheng, Iona; Wilkens, Lynne R.; Schumacher, Fredrick R.; Kolonel, Laurence; Carlson, Chris S.; Crawford, Dana C.; Goodloe, Robert J.; Dilks, Holli H.; Baker, Paxton; Richardson, Danielle; Matise, Tara C.; Ambite, José Luis; Song, Fengju; Qureshi, Abrar A.; Zhang, Mingfeng; Duggan, David; Hutter, Carolyn; Hindorff, Lucia; Bush, William S.; Kooperberg, Charles; Le Marchand, Loic; Peters, Ulrike (Public Library of Science, 2015)
      Background: Several regions of the genome show pleiotropic associations with multiple cancers. We sought to evaluate whether 181 single-nucleotide polymorphisms previously associated with various cancers in genome-wide ...

    • Pleiotropic Effects of Calcium Channel Blockers 

      Mason, R. Preston (Current Science Inc., 2012)
      Clinical trials have reported reduced cardiovascular events with certain antihypertensive agents at a rate that could not be predicted by changes in brachial arterial pressure alone. These findings may be explained, in ...

    • Pleural Fluid Mesothelin as an Adjunct to the Diagnosis of Pleural Malignant Mesothelioma 

      Creaney, Jenette; Segal, Amanda; Olsen, Nola; Dick, Ian M.; Musk, A. W(Bill); Skates, Steven J.; Robinson, Bruce W. (Hindawi Publishing Corporation, 2014)
      Rationale:. The diagnosis of pleural malignant mesothelioma (MM) by effusion cytology may be difficult and is currently controversial. Effusion mesothelin levels are increased in patients with MM but the clinical role of ...