Browsing HMS Scholarly Articles by Title
Now showing items 12987-13006 of 17918
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Postnatal onset of retinal degeneration by loss of embryonic Ezh2 repression of Six1
(Nature Publishing Group, 2016)Some adult-onset disorders may be linked to dysregulated embryonic development, yet the mechanisms underlying this association remain poorly understood. Congenital retinal degenerative diseases are blinding disorders ... -
Postoperative Care in an Intermediate-Level Medical Unit After Head and Neck Microvascular Free Flap Reconstruction
(Wiley, 2018-11-28)Objective: The need for intensive care unit (ICU) admission and mechanical ventilation after head and neck microvascular free flap reconstructive surgery remains controversial. Our institution has maintained a longstanding ... -
Postoperative Intensive Care Unit Requirements After Elective Craniotomy
(Elsevier BV, 2014)Objective: Commonly, patients undergoing craniotomy are admitted to an intensive care setting post-operatively to allow for close monitoring. We aim to determine the frequency with which patients who have undergone elective ... -
Postoperative Pain Management in DIEP Flap Breast Reconstruction: Identification of Patients With Poor Pain Control
(Open Science, 2010)Objective: Adequate control of postoperative pain directly improves patient satisfaction and outcomes, and timely identification of patients with poorly controlled pain is essential. Pain management protocols are best ... -
Postoperative pulmonary embolism in a three year old with Klippel–Trenaunay syndrome
(Dove Medical Press, 2009)Massive pulmonary embolism (PE) in a small child is a rare event and unified guidelines for its treatment are missing. Timely diagnosis and management of massive pulmonary embolism is of crucial importance for a good ... -
Postsynaptic SDC2 induces transsynaptic signaling via FGF22 for bidirectional synaptic formation
(Nature Publishing Group, 2016)Functional synapse formation requires tight coordination between pre- and post-synaptic termini. Previous studies have shown that postsynaptic expression of heparan sulfate proteoglycan syndecan-2 (SDC2) induces dendritic ... -
Posttraining Sleep Enhances Automaticity in Perceptual Discrimination
(Massachusetts Institute of Technology Press (MIT Press), 2004)Perceptual learning can develop over extended periods, with slow, at times sleep-dependent, improvement seen several days after training. As a result, performance can become more automatic, that is, less dependent on ... -
Posttranscriptional Control of Adipocyte Differentiation through Activation of Phosphoinositide 3-Kinase
(American Society for Biochemistry and Molecular Biology, 1998) -
Posttraumatic Distress Symptoms and Their Response to Treatment in Adults With Prolonged Grief Disorder
(Physicians Postgraduate Press, Inc, 2021-04-20)Objective: Posttraumatic stress disorder and Prolonged Grief Disorder (PGD) arise following major life stressors, and may share some overlapping symptomatology. This study aimed to examine the presence and response to ... -
Posttraumatic Psychological Symptoms are Associated with Reduced Inhibitory Control, not General Executive Dysfunction
(Cambridge University Press, 2015) -
Posttraumatic stress disorder, depression, and health-related quality of life in patients with bipolar disorder: Review and new data from a multi-site community clinic sample
(Elsevier BV, 2013)Background Evidence suggests that patients with bipolar disorder have an elevated risk for comorbid posttraumatic stress disorder (PTSD) compared to those without a bipolar diagnosis. Although bipolar disorder is ... -
Postural Changes in Blood Pressure Associated with Interactions between Candidate Genes for Chronic Respiratory Diseases and Exposure to Particulate Matter
(National Institute of Environmental Health Sciences, 2009)Background: Fine particulate matter [aerodynamic diameter ≤ 2.5 μm (PM2.5)] has been associated with autonomic dysregulation.Objective We hypothesized that PM2.5 influences postural changes in systolic blood pressure (ΔSBP) ... -
Postural sway and regional cerebellar volume in adults with attention-deficit/hyperactivity disorder
(Elsevier, 2015)Objective: Motor abnormalities, including impaired balance and increased postural sway, are commonly reported in children with ADHD, but have yet to be investigated in adults with ADHD. Furthermore, although these abnormalities ... -
Potassium Measures and Their Associations with Glucose and Diabetes Risk: The Multi-Ethnic Study of Atherosclerosis (MESA)
(Public Library of Science, 2016)Background: Recent studies have found low-normal potassium (K) to be associated with increased diabetes risk. We sought to verify these associations in a multi-ethnic US cohort; and to determine if these associations extend ... -
Potency and Stereoselectivity of Cyclopropavir Triphosphate Action on Human Cytomegalovirus DNA Polymerase
(American Society for Microbiology, 2016)Cyclopropavir (CPV) is a promising antiviral drug against human cytomegalovirus (HCMV). As with ganciclovir (GCV), the current standard for HCMV treatment, activation of CPV requires multiple steps of phosphorylation and ... -
Potent and Broad Neutralization of HIV-1 by a Llama Antibody Elicited by Immunization
(The Rockefeller University Press, 2012)Llamas (Lama glama) naturally produce heavy chain–only antibodies (Abs) in addition to conventional Abs. The variable regions (VHH) in these heavy chain–only Abs demonstrate comparable affinity and specificity for antigens ... -
Potent Cell-Intrinsic Immune Responses in Dendritic Cells Facilitate HIV-1-Specific T Cell Immunity in HIV-1 Elite Controllers
(Public Library of Science, 2015)The majority of HIV-1 elite controllers (EC) restrict HIV-1 replication through highly functional HIV-1-specific T cell responses, but mechanisms supporting the evolution of effective HIV-1-specific T cell immunity in these ... -
Potent Neutralizing Antibodies Directed to Multiple Epitopes on SARS-CoV-2 Spike
(Cold Spring Harbor Laboratory, 2020-06-18)The SARS-CoV-2 pandemic rages on with devasting consequences not only on human lives but also on the global economy. The discovery and development of virus-neutralizing monoclonal antibodies may be one approach that could ... -
Potential Biases in Estimating Absolute and Relative Case-Fatality Risks during Outbreaks
(Public Library of Science, 2015)Estimating the case-fatality risk (CFR)—the probability that a person dies from an infection given that they are a case—is a high priority in epidemiologic investigation of newly emerging infectious diseases and sometimes ... -
Potential Circadian Effects on Translational Failure for Neuroprotection
(Springer Science and Business Media LLC, 2020-06-03)Neuroprotectant strategies that have worked in rodent models of stroke have failed to provide protection in clinical trials. Here we show that the opposite circadian cycles in nocturnal rodents versus diurnal humans may ...