Browsing HMS Scholarly Articles by Title
Now showing items 13040-13059 of 17922
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PP2ARts1 is a master regulator of pathways that control cell size
(The Rockefeller University Press, 2014)Cell size checkpoints ensure that passage through G1 and mitosis occurs only when sufficient growth has occurred. The mechanisms by which these checkpoints work are largely unknown. PP2A associated with the Rts1 regulatory ... -
PPAR\(\alpha\) Deficiency in Inflammatory Cells Suppresses Tumor Growth
(Public Library of Science, 2007)Inflammation in the tumor bed can either promote or inhibit tumor growth. Peroxisome proliferator-activated receptor (PPAR)\(\alpha\) is a central transcriptional suppressor of inflammation, and may therefore modulate tumor ... -
PPARGC1α gene DNA methylation variations in human placenta mediate the link between maternal hyperglycemia and leptin levels in newborns
(BioMed Central, 2016)Background: Children exposed to gestational diabetes mellitus (GDM) are at a higher risk of developing obesity and type 2 diabetes. This susceptibility might involve brown adipose tissue (BAT), which is suspected to protect ... -
PPARβ/δ Regulates Glucocorticoid- and Sepsis-Induced FOXO1 Activation and Muscle Wasting
(Public Library of Science, 2013)FOXO1 is involved in glucocorticoid- and sepsis-induced muscle wasting, in part reflecting regulation of atrogin-1 and MuRF1. Mechanisms influencing FOXO1 expression in muscle wasting are poorly understood. We hypothesized ... -
PPARγ Deficiency Results in Reduced Lung Elastic Recoil and Abnormalities in Airspace Distribution
(BioMed Central, 2010)Background: Peroxisome proliferator-activated receptor (PPAR)-γ is a nuclear hormone receptor that regulates gene expression, cell proliferation and differentiation. We previously described airway epithelial cell PPARγ ... -
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage
(BMJ Publishing Group, 2015)Objectives: We have previously shown that peroxisome proliferator-activated receptor gamma (PPARγ), a transcription factor, is essential for the normal growth and development of cartilage. In the present study, we created ... -
PPARγ is a Major Driver of the Accumulation and Phenotype of Adipose-Tissue \(T_{reg}\) Cells
(Nature Publishing Group, 2012)Obesity and type-2 diabetes have increased markedly over the past few decades, in parallel. One of the major links between these two disorders is chronic, low-grade inflammation. Prolonged nutrient excess promotes the ... -
PPIRank - an advanced method for ranking protein-protein interations in TAP/MS data
(BioMed Central, 2013)Background: Tandem affinity purification coupled with mass-spectrometry (TAP/MS) analysis is a popular method for the identification of novel endogenous protein-protein interactions (PPIs) in large-scale. Computational ... -
PprA Contributes to Deinococcus radiodurans Resistance to Nalidixic Acid, Genome Maintenance after DNA Damage and Interacts with Deinococcal Topoisomerases
(Public Library of Science, 2014)PprA is known to contribute to Deinococcus radiodurans' remarkable capacity to survive a variety of genotoxic assaults. The molecular bases for PprA's role(s) in the maintenance of the damaged D. radiodurans genome are ... -
Practicability confirmation by meta-analysis of intravitreal ranibizumab compared to photodynamic therapy to treat polypoidal choroidal vasculopathy
(Molecular Vision, 2015)Purpose The literatures show that photodynamic therapy (PDT) and intravitreal ranibizumab (IVR) have their own specific advantages in treating polypoidal choroidal vasculopathy (PCV). Using a meta-analysis, we want to ... -
Practical and Theoretical Barriers to the Prevention of Accelerated Atherosclerosis in Systemic Lupus Erythematosus
(BioMed Central, 2003)Accelerated atherosclerotic vascular disease (ASVD) is a major cause of death in systemic lupus erythematosus (SLE). Although many authorities are calling for aggressive assessment and management of cardiac risk factors ... -
A practical application of text mining to literature on cognitive rehabilitation and enhancement through neurostimulation
(Frontiers Media S.A., 2014)The exponential growth in publications represents a major challenge for researchers. Many scientific domains, including neuroscience, are not yet fully engaged in exploiting large bodies of publications. In this paper, we ... -
A Practical Approach to the Measurement of a Campus Influenza Campaign and Predictors of Vaccination Uptake among College Students
(The George Washington University School of Public Health and Health Services, 2011)This case describes the tools and approach developed for use in the evaluation of a health communication campaign at a major university within the context of the H1N1 influenza threat during the academic year 2009-2010. The ... -
Practical Consensus Guidelines for the Management of Enuresis
(Springer-Verlag, 2012)Despite the high prevalence of enuresis, the professional training of doctors in the evaluation and management of this condition is often minimal and/or inconsistent. Therefore, patient care is neither optimal nor efficient, ... -
Practical Implications of the Non-Linear Relationship between the Test Positivity Rate and Malaria Incidence
(Public Library of Science, 2016)Background: The test positivity rate (TPR), defined as the number of laboratory-confirmed malaria tests per 100 suspected cases examined, is widely used by malaria surveillance programs as one of several key indicators of ... -
A Practical Platform for Blood Biomarker Study by Using Global Gene Expression Profiling of Peripheral Whole Blood
(Public Library of Science, 2009)Background: Although microarray technology has become the most common method for studying global gene expression, a plethora of technical factors across the experiment contribute to the variable of genome gene expression ... -
Practical Radiosynthesis and Preclinical Neuroimaging of [11C]isradipine, A Calcium Channel Antagonist
(2016)In the interest of developing in vivo positron emission tomography (PET) probes for neuroimaging of calcium channels, we have prepared a carbon-11 isotopologue of a dihydropyridine Ca2+-channel antagonist, isradipine. ... -
The Practice of Privacy
(Council on Library and Information Resource., 2015)Drawing on our experiences managing CLIR-funded processing initiatives for public health collections containing protected health information as part of the grant “Private Practices, Public Health: Privacy-Aware Processing ... -
Practice Patterns of Naturopathic Physicians: Results from a Random Survey of Licensed Practitioners in Two US States
(BioMed Central, 2004)Background: Despite the growing use of complementary and alternative medicine (CAM) by consumers in the U.S., little is known about the practice of CAM providers. The objective of this study was to describe and compare the ... -
The PRC2-associated factor C17orf96 is a novel CpG island regulator in mouse ES cells
(Nature Publishing Group, 2015)CpG islands (CGIs) are key DNA regulatory elements in the vertebrate genome and are often found at gene promoters. In mammalian embryonic stem (ES) cells, CGIs are decorated by either the active or repressive histone marks, ...