Browsing HMS Scholarly Articles by Title

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    • Atherosclerosis: Successes, Surprises, and Future Challenges 

      Libby, Peter; Bornfeldt, Karin E.; Tall, Alan R. (Ovid Technologies (Wolters Kluwer Health), 2016)
      This new compendium of 16 articles "reviews the current state-of-the-art of atherosclerosis research spanning from a global health perspective to fundamental molecular mechanisms. The editors intend this collection of ...

    • Atherosclerotic Biomarkers and Aortic Atherosclerosis by Cardiovascular Magnetic Resonance Imaging in the Framingham Heart Study 

      Hong, Susie N.; Gona, Philimon; Fontes, Joao D.; Oyama, Noriko; Chan, Raymond H.; Kenchaiah, Satish; Tsao, Connie W.; Yeon, Susan B.; Schnabel, Renate B.; Keaney, John F.; O'Donnell, Christopher J.; Benjamin, Emelia J.; Manning, Warren J. (Blackwell Publishing Ltd, 2013)
      Background: The relations between subclinical atherosclerosis and inflammatory biomarkers have generated intense interest but their significance remains unclear. We sought to determine the association between a panel of ...

    • An Atlas of Genetic Correlations across Human Diseases and Traits 

      Bulik-Sullivan, Brendan; Finucane, Hilary K; Anttila, Verneri; Gusev, Alexander; Day, Felix R.; Loh, Po-Ru; Duncan, Laramie; Perry, John R.B.; Patterson, Nick; Robinson, Elise B.; Daly, Mark J.; Price, Alkes L.; Neale, Benjamin M. (2015)
      Identifying genetic correlations between complex traits and diseases can provide useful etiological insights and help prioritize likely causal relationships. The major challenges preventing estimation of genetic correlation ...

    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 

      Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb; Pomerantz, Mark; Li, Fugen; Long, Henry W.; Ingles, Sue A.; Kittles, Rick A.; Strom, Sara S.; Rybicki, Benjamin A.; Nemesure, Barbara; Isaacs, William B.; Zheng, Wei; Pettaway, Curtis A.; Yeboah, Edward D.; Tettey, Yao; Biritwum, Richard B.; Adjei, Andrew A.; Tay, Evelyn; Truelove, Ann; Niwa, Shelley; Chokkalingam, Anand P.; John, Esther M.; Murphy, Adam B.; Signorello, Lisa B.; Carpten, John; Leske, M. Cristina; Wu, Suh-Yuh; Hennis, Anslem J. M.; Neslund-Dudas, Christine; Hsing, Ann W.; Chu, Lisa; Goodman, Phyllis J.; Klein, Eric A.; Witte, John S.; Casey, Graham; Kaggwa, Sam; Cook, Michael B.; Stram, Daniel O.; Blot, William J.; Eeles, Rosalind A.; Easton, Douglas; Kote-Jarai, ZSofia; Al Olama, Ali Amin; Benlloch, Sara; Muir, Kenneth; Giles, Graham G.; Southey, Melissa C.; Fitzgerald, Liesel M.; Gronberg, Henrik; Wiklund, Fredrik; Aly, Markus; Henderson, Brian E.; Schleutker, Johanna; Wahlfors, Tiina; Tammela, Teuvo L. J.; Nordestgaard, Børge G.; Key, Tim J.; Travis, Ruth C.; Neal, David E.; Donovan, Jenny L.; Hamdy, Freddie C.; Pharoah, Paul; Pashayan, Nora; Khaw, Kay-Tee; Stanford, Janet L.; Thibodeau, Stephen N.; McDonnell, Shannon K.; Schaid, Daniel J.; Maier, Christiane; Vogel, Walther; Luedeke, Manuel; Herkommer, Kathleen; Kibel, Adam S.; Cybulski, Cezary; Wokolorczyk, Dominika; Kluzniak, Wojciech; Cannon-Albright, Lisa; Teerlink, Craig; Brenner, Hermann; Dieffenbach, Aida K.; Arndt, Volker; Park, Jong Y.; Sellers, Thomas A.; Lin, Hui-Yi; Slavov, Chavdar; Kaneva, Radka; Mitev, Vanio; Batra, Jyotsna; Spurdle, Amanda; Clements, Judith A.; Teixeira, Manuel R.; Pandha, Hardev; Michael, Agnieszka; Paulo, Paula; Maia, Sofia; Kierzek, Andrzej; Cook, Margaret; Guy, Michelle; Govindasami, Koveela; Leongamornlert, Daniel; Sawyer, Emma J.; Wilkinson, Rosemary; Saunders, Edward J.; Tymrakiewicz, Malgorzata; Dadaev, Tokhir; Morgan, Angela; Fisher, Cyril; Hazel, Steve; Livni, Naomi; Lophatananon, Artitaya; Pedersen, John; Hopper, John L.; Adolfson, Jan; Stattin, Paer; Johansson, Jan-Erik; Cavalli-Bjoerkman, Carin; Karlsson, Ami; Broms, Michael; Auvinen, Anssi; Kujala, Paula; Maeaettaenen, Liisa; Murtola, Teemu; Taari, Kimmo; Weischer, Maren; Nielsen, Sune F.; Klarskov, Peter; Roder, Andreas; Iversen, Peter; Wallinder, Hans; Gustafsson, Sven; Cox, Angela; Brown, Paul; George, Anne; Marsden, Gemma; Lane, Athene; Davis, Michael; Tillmans, Lori; Riska, Shaun; Wang, Liang; Rinckleb, Antje; Lubiski, Jan; Stegmaier, Christa; Pow-Sang, Julio; Park, Hyun; Radlein, Selina; Rincon, Maria; Haley, James; Zachariah, Babu; Kachakova, Darina; Popov, Elenko; Mitkova, Atanaska; Vlahova, Aleksandrina; Dikov, Tihomir; Christova, Svetlana; Heathcote, Peter; Wood, Glenn; Malone, Greg; Saunders, Pamela; Eckert, Allison; Yeadon, Trina; Kerr, Kris; Collins, Angus; Turner, Megan; Srinivasan, Srilakshmi; Kedda, Mary-Anne; Alexander, Kimberly; Omara, Tracy; Wu, Huihai; Henrique, Rui; Pinto, Pedro; Santos, Joana; Barros-Silva, Joao; Conti, David V.; Albanes, Demetrius; Berg, Christine; Berndt, Sonja I.; Campa, Daniele; Crawford, E. David; Diver, W. Ryan; Gapstur, Susan M.; Gaziano, J. Michael; Giovannucci, Edward; Hoover, Robert; Hunter, David J.; Johansson, Mattias; Kraft, Peter; Le Marchand, Loic; Lindström, Sara; Navarro, Carmen; Overvad, Kim; Riboli, Elio; Siddiq, Afshan; Stevens, Victoria L.; Trichopoulos, Dimitrios; Vineis, Paolo; Yeager, Meredith; Trynka, Gosia; Raychaudhuri, Soumya; Schumacher, Frederick R.; Price, Alkes L.; Freedman, Matthew L.; Haiman, Christopher A.; Pasaniuc, Bogdan (Nature Publishing Group, 2016)
      Although genome-wide association studies have identified over 100 risk loci that explain ∼33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...

    • Atlas-Guided Segmentation of Vervet Monkey Brain MRI 

      Fedorov, Andriy; Li, Xiaoxing; Pohl, Kilian M; Bouix, Sylvain; Styner, Martin; Addicott, Merideth; Wyatt, Chris; Daunais, James B; Wells, William Mercer; Kikinis, Ron (Bentham Science, 2011)
      The vervet monkey is an important nonhuman primate model that allows the study of isolated environmental factors in a controlled environment. Analysis of monkey MRI often suffers from lower quality images compared with ...

    • ATM-deficient Thymic Lymphoma is Associated with Aberrant tcrd Rearrangement and Gene Amplification 

      Bassing, Craig H.; Brush, James W.; Patel, Harin; Goff, Peter H.; Gatti, Richard A.; Zha, Shan; Sanda, Takaomi; Murphy, Michael M.; Tepsuporn, Suprawee; Look, A. Thomas; Alt, Frederick W. (The Rockefeller University Press, 2010)
      Ataxia telangiectasia mutated (ATM) deficiency predisposes humans and mice to T lineage lymphomas with recurrent chromosome 14 translocations involving the T cell receptor α/δ (Tcra/d) locus. Such translocations have been ...

    • Atomic structure reveals the unique capsid organization of a dsRNA virus 

      Pan, Junhua; Dong, Liping; Lin, Li; Ochoa, Wendy F.; Sinkovits, Robert S.; Havens, Wendy M.; Nibert, Max L.; Baker, Timothy S.; Ghabrial, Said A.; Tao, Yizhi Jane (National Academy of Sciences, 2009)
      For most dsRNA viruses, the genome-enclosing capsid comprises 120 copies of a single capsid protein (CP) organized into 60 icosahedrally equivalent dimers, generally identified as 2 nonsymmetrically interacting CP molecules ...

    • Atorvastatin Therapy is Associated with Greater and Faster Cerebral Hemodynamic Response 

      Xu, Guofan; Fitzgerald, Michele E.; Wen, Zhifei; Fain, Sean B.; Alsop, David; Carroll, Timothy; Ries, Michele L.; Rowley, Howard A.; Sager, Mark A.; Asthana, Sanjay; Johnson, Sterling C.; Carlsson, Cynthia M. (Springer Science and Business Media LLC, 2008-06)
      Hypercholesterolemia in midlife increases the risk of subsequent cognitive decline, neurovascular disease, and Alzheimer’s disease (AD), and statin use is associated with reduced prevalence of these outcomes. While statins ...

    • Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis 

      Tang, Ting-Ting; Song, You; Ding, Ying-Jun; Liao, Yu-Hua; Yu, Xian; Du, Rong; Xiao, Hong; Yuan, Jing; Zhou, Zi-Hua; Liao, Meng-Yang; Yao, Rui; Jevallee, Harish; Shi, Guo-Ping; Cheng, Xiang (American Society for Biochemistry and Molecular Biology, 2011)
      In this study, we investigated the hypothesis that regulatory T cells (T-reg) are involved in the immunomodulatory effects of statins on rheumatoid arthritis (RA) patients. The 12-week study cohort consisted of 55 RA ...

    • ATP Binding Cassette Transporter ABCA7 Regulates NKT Cell Development and Function by Controlling CD1d Expression and Lipid Raft Content 

      Nowyhed, Heba N.; Chandra, Shilpi; Kiosses, William; Marcovecchio, Paola; Andary, Farah; Zhao, Meng; Fitzgerald, Michael L.; Kronenberg, Mitchell; Hedrick, Catherine C. (Nature Publishing Group, 2017)
      ABCA7 is an ABC transporter expressed on the plasma membrane, and actively exports phospholipid complexes from the cytoplasmic to the exocytoplasmic leaflet of membranes. Invariant NKT (iNKT) cells are a subpopulation of ...

    • ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis 

      Luo, Bin; Wang, Minggang; Hou, Nengyi; Hu, Xiao; Jia, Guiqing; Qin, Xianpeng; Zuo, Xiaofei; Liu, Yang; Luo, Kun; Song, Wei; Wang, Kang; Pang, Minghui (Neoplasia Press, 2016)
      Helicobacter pylori infection is the strongest risk factor for development of gastric cancer. Host cellular stress responses, including inflammatory and immune responses, have been reported highly linked to H. pylori-induced ...

    • ATP1A3 Mutation in Adult Rapid-Onset Ataxia 

      Sweadner, Kathleen J.; Toro, Camilo; Whitlow, Christopher T.; Snively, Beverly M.; Cook, Jared F.; Ozelius, Laurie J.; Markello, Thomas C.; Brashear, Allison (Public Library of Science, 2016)
      A 21-year old male presented with ataxia and dysarthria that had appeared over a period of months. Exome sequencing identified a de novo missense variant in ATP1A3, the gene encoding the α3 subunit of Na,K-ATPase. Several ...

    • ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction 

      Hodi, F. Stephen; Schmollinger, Jan C.; Soiffer, Robert J.; Salgia, Ravi; Lynch, Thomas; Ritz, Jerome; Alyea, Edwin P.; Yang, Jihong; Neuberg, Donna; Mihm, Martin; Dranoff, Glenn (National Academy of Sciences, 2002)
      An important goal of cancer immunology is the identification of antigens associated with tumor destruction. Vaccination with irradiated tumor cells engineered to secrete granulocyte/macrophage colony-stimulating factor ...

    • The ATPase Module of Mammalian SWI/SNF Family Complexes Mediates Subcomplex Identity and Catalytic Activity–independent Genomic Targeting 

      Mashtalir, Nazar; Wang, Lu; Kadoch, Cigall; Pan, Joshua; McKenzie, Zachary; D’Avino, Andrew; Lareau, Caleb; St. Pierre, Roodolph; Shilatifard, Ali (Springer Science and Business Media LLC, 2019-03-11)
      Perturbations to mammalian SWI/SNF (mSWI/SNF) chromatin remodeling complexes have been widely implicated as driving events in cancer1. One such perturbation is the dual loss of the SMARCA4 and SMARCA2 ATPase subunits in ...

    • Atrial natriuretic peptide is negatively regulated by microRNA-425 

      Arora, Pankaj; Wu, Connie; Khan, Abigail May; Bloch, Donald Bendit; Davis-Dusenbery, Brandi Nicole; Ghorbani, Anahita; Spagnolli, Ester; Martinez, Andrew; Ryan, Allicia; Tainsh, Laurel T.; Kim, Samuel M; Rong, Jian; Huan, Tianxiao; Freedman, Jane E.; Levy, Daniel; Miller, Karen Klahr; Hata, Akiko; Del Monte, Federica; Vandenwijngaert, Sara; Swinnen, Melissa; Janssens, Stefan; Holmes, Tara M.; Buys, Emmanuel; Bloch, Kenneth Daniel; Newton-Cheh, Christopher Holmes; Wang, Thomas (American Society for Clinical Investigation, 2013)
      Numerous common genetic variants have been linked to blood pressure, but no underlying mechanism has been elucidated. Population studies have revealed that the variant rs5068 (A/G) in the 3′ untranslated region of NPPA, ...

    • Atrial Septum Fat Deposition and Atrial Anatomy Assessed by Cardiac Magnetic Resonance: Relationship to Atrial Electrophysiology 

      Rizzi, Patricia B; Mewton, Nathan; Tereshchencko, Larisa G; Strauss, David G; Liu, Chia-Ying; Marchlinski, Francis E; Spooner, Peter M; Kellman, Peter; Lima, Joao A; Verrier, Richard Leonard; Cox, Christopher; Nearing, Bruce David (BioMed Central, 2012)
      To assess the prevalence of fat deposition in the atrial septum with and its relationship with 12-lead electrocardiogram (ECG) atrial parameters (PR interval, P wave duration) and the presence of atrial fibrillation.

    • Atrophic Gastritis: A Related Factor for Osteoporosis in Elderly Women 

      Kim, Hye Won; Kim, Yang-Hyun; Han, Kyungdo; Nam, Ga Eun; Kim, Gwang Seon; Han, Byoung-Duck; Lee, Anna; Ahn, Ji Yong; Ko, Byung Joon (Public Library of Science, 2014)
      Purpose Osteoporosis poses a great threat to the aging society. Hypochlorhydric or achlorhydric conditions are risk factors for osteoporosis. Atrophic gastritis also decreases gastric acid production; however, the role of ...

    • Atropine for Critical Care Intubation in a Cohort of 264 Children and Reduced Mortality Unrelated to Effects on Bradycardia 

      Jones, Peter; Peters, Mark J.; Pinto da Costa, Nathalia; Kurth, Tobias; Alberti, Corinne; Kessous, Katia; Lode, Noella; Dauger, Stephane (Public Library of Science, 2013)
      Background: Atropine has is currently recommended to facilitate haemodynamic stability during critical care intubation. Our objective was to determine whether atropine use at induction influences ICU mortality. ...

    • Attachment disorganization and controlling behavior in middle childhood: maternal and child precursors and correlates 

      Bureau, Jean François; Ann Easlerbrooks, M.; Lyons-Ruth, Karlen (Informa UK Limited, 2009)
      Main, Kaplan, and Cassidy's (1985) conceptualizations of disorganization in infancy and controlling behavior in preschool forged new directions in attachment research. However, there currently is no valid coding system for ...

    • Attachment Studies with Borderline Patients: A Review 

      Agrawal, Hans R.; Gunderson, John Gunder; Holmes, Bjarne M.; Lyons-Ruth, Karlen (Ovid Technologies (Wolters Kluwer Health), 2004)
      Clinical theorists have suggested that disturbed attachments are central to borderline personality disorder (BPD) psychopathology. This article reviews 13 empirical studies that examine the types of attachment found in ...