Browsing HMS Scholarly Articles by Title
Now showing items 13868-13887 of 17918
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Random Timing in Signaling Cascades
(European Molecular Biology Organization, 2007) -
Randomised clinical trial: alosetron improves quality of life and reduces restriction of daily activities in women with severe diarrhoea-predominant IBS
(Blackwell Publishing Ltd, 2012)Background: Patients with irritable bowel syndrome with diarrhoea (IBS-D) experience restriction in daily activities and decreased health-related quality of life (QOL). Aim To investigate effects of alosetron on ... -
Randomised controlled trial comparing hypnotherapy versus gabapentin for the treatment of hot flashes in breast cancer survivors: a pilot study
(BMJ Publishing Group, 2013)Objectives: To compare the efficacy of hypnotherapy versus gabapentin for the treatment of hot flashes in breast cancer survivors, and to evaluate the feasibility of conducting a clinical trial comparing a drug with a ... -
A Randomised Controlled Trial of Bumetanide in the Treatment of Autism in Children
(Nature Publishing Group, 2012)Gamma aminobutyric acid (GABA)-mediated synapses and the oscillations they orchestrate are altered in autism. GABA-acting benzodiazepines exert in some patients with autism paradoxical effects, raising the possibility that ... -
Randomised controlled trials in plastic surgery: a systematic review of reporting quality
(Springer Berlin Heidelberg, 2013)Background: We recently conducted a systematic review of the methodological quality of randomised controlled trials (RCTs) in plastic surgery. In accordance with convention, we are here separately reporting a systematic ... -
A Randomised, Placebo-Controlled, First-In-Human Study of a Novel Clade C Therapeutic Peptide Vaccine Administered Ex Vivo to Autologous White Blood Cells in HIV Infected Individuals
(Public Library of Science, 2013)Background: Preclinical studies of overlapping 15mer peptides, spanning SIV, SHIV or HIV, pulsed on autologous PBMC ex vivo have demonstrated high level, virus-specific T cell responses and viral suppression in non-human ... -
Randomized control trial of computer-based rehabilitation of spatial neglect syndrome: the RESPONSE trial protocol
(BioMed Central, 2014)Background: Spatial neglect is a frequent and debilitating consequence of acquired brain injury and currently has no widely accepted standard of care. While previous interventions for spatial neglect have targeted patients’ ... -
RANDOMIZED CONTROLLED CLINICAL TRIALS IN ORTHOPEDICS: DIFFICULTIES AND LIMITATIONS
(Elsevier, 2011)Randomized controlled clinical trials (RCTs) are considered to be the gold standard for evidence-based medicine nowadays, and are important for directing medical practice through consistent scientific observations. Steps ... -
A randomized controlled evaluation of a spiritually integrated treatment for subclinical anxiety in the Jewish community, delivered via the Internet
(Elsevier BV, 2010)OBJECTIVE: This study evaluated the efficacy of a spiritually integrated treatment (SIT) for subclinical anxiety in the Jewish community. METHOD: One hundred and twenty-five self-reported religious Jewish individuals with ... -
Randomized controlled trial of a health plan-level mood disorders psychosocial intervention for solo or small practices
(BioMed Central, 2014)Background: Mood disorders represent the most expensive mental disorders for employer-based commercial health plans. Collaborative care models are effective in treating chronic physical and mental illnesses at little to ... -
A Randomized Controlled Trial of a Novel Mixed Monoamine Reuptake Inhibitor in Adults with ADHD
(BioMed Central, 2008)Background: NS2359 is a potent reuptake blocker of noradrenalin, dopamine, and serotonin. The aim of the study was to investigate the efficacy, safety and cognitive function of NS2359 in adults with a DSM IV diagnosis of ... -
A Randomized Controlled Trial of Cognitive Behavioral Therapy for Adherence and Depression (CBT-AD) in Patients With Uncontrolled Type 2 Diabetes
(American Diabetes Association, 2014)OBJECTIVE To test cognitive behavioral therapy for adherence and depression (CBT-AD) in type 2 diabetes. We hypothesized that CBT-AD would improve adherence; depression; and, secondarily, hemoglobin A1c (A1C). RESEARCH ... -
Randomized Controlled Trial of Parent Therapeutic Education on Antibiotics to Improve Parent Satisfaction and Attitudes in a Pediatric Emergency Department
(Public Library of Science, 2013)Objective: To evaluate therapeutic education delivered in a pediatric emergency department to improve parents’ satisfaction and attitudes about judicious antibiotic use. Methods: In an emergency department of a tertiary ... -
Randomized Controlled Trial of Social Media: Effect of Increased Intensity of the Intervention
(John Wiley and Sons Inc., 2016)Background: A prior randomized controlled trial of social media exposure at Circulation determined that social media did not increase 30‐day page views. Whether insufficient social media intensity contributed to these ... -
Randomized controlled trials – a matter of design
(Dove Medical Press, 2016)Randomized controlled trials (RCTs) are the hallmark of evidence-based medicine and form the basis for translating research data into clinical practice. This review summarizes commonly applied designs and quality indicators ... -
Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme
(American Society of Clinical Oncology (ASCO), 2008)Purpose Cilengitide, an inhibitor of αvβ3 and αvβ5 integrin receptors, demonstrated minimal toxicity and durable activity across a wide range of doses administered to adults with recurrent glioblastoma multiforme (GBM) ... -
A randomized placebo-controlled pilot study of N-acetylcysteine in youth with autism spectrum disorder
(BioMed Central, 2016)Background: Social impairment is a defining feature of autism spectrum disorder (ASD) with no demonstrated effective pharmacologic treatments. The goal of this study was to evaluate efficacy, safety, and tolerability of ... -
Randomized placebo-controlled study of intravenous methylnaltrexone in postoperative ileus
(Maney Publishing, 2013)Objective: This phase 2 study evaluated the safety and activity of intravenous methylnaltrexone on the duration of postoperative ileus in patients undergoing segmental colectomy. Methods: Adults (aged 18 years or older) ... -
A Randomized Placebo-Controlled Trial of Targeted Prefrontal Cortex Modulation with Bilateral tDCS in Patients with Crack-Cocaine Dependence
(Oxford University Press, 2015)Background: Transcranial direct current stimulation over the dorsolateral prefrontal cortex has been shown to be clinically useful in the treatment of drug addiction. Methods: We conducted a double-blind randomized clinical ... -
A Randomized Trial Assessing the Clinical Efficacy and Microbial Eradication of 1% Azithromycin Ophthalmic Solution vs Tobramycin in Adult and Pediatric Subjects with Bacterial Conjunctivitis
(Dove Medical Press, 2007)Objective: The study was designed to evaluate the efficacy of an ophthalmic formulation of 1% azithromycin in DuraSite® (AzaSite™, InSite Vision, Alameda CA, USA) and demonstrate equivalence with 0.3% tobramycin ophthalmic ...