Now showing items 14335-14354 of 17917

    • Remodeling of retrotransposon elements during epigenetic induction of adult visual cortical plasticity by HDAC inhibitors 

      Lennartsson, Andreas; Arner, Erik; Fagiolini, Michela; Saxena, Alka; Andersson, Robin; Takahashi, Hazuki; Noro, Yukihiko; Sng, Judy; Sandelin, Albin; Hensch, Takao K.; Carninci, Piero (BioMed Central, 2015)
      Background: The capacity for plasticity in the adult brain is limited by the anatomical traces laid down during early postnatal life. Removing certain molecular brakes, such as histone deacetylases (HDACs), has proven to ...
    • Remodeling of the Intestinal Brush Border Underlies Adhesion and Virulence of an Enteric Pathogen 

      Zhou, Xiaohui; Massol, Ramiro H.; Nakamura, Fumihiko; Chen, Xiang; Gewurz, Benjamin E.; Davis, Brigid M.; Lencer, Wayne I.; Waldor, Matthew K. (American Society of Microbiology, 2014)
      ABSTRACT Intestinal colonization by Vibrio parahaemolyticus—the most common cause of seafood-borne bacterial enteritis worldwide—induces extensive disruption of intestinal microvilli. In orogastrically infected infant ...
    • Remote control of macrophage production by cancer 

      Cortez-Retamozo, Virna; Engblom, Camilla; Pittet, Mikael J. (Landes Bioscience, 2013)
      The communication between tumor and host cells involves signals that act across extended distances in the body. Recent evidence indicates that the hormone angiotensin II is overproduced by lung adenocarcinoma to remotely ...
    • Remote video auditing with real-time feedback in an academic surgical suite improves safety and efficiency metrics: a cluster randomised study 

      Overdyk, Frank J; Dowling, Oonagh; Newman, Sheldon; Glatt, David; Chester, Michelle; Armellino, Donna; Cole, Brandon; Landis, Gregg S; Schoenfeld, David; DiCapua, John F (BMJ Publishing Group, 2016)
      Importance Compliance with the surgical safety checklist during operative procedures has been shown to reduce inhospital mortality and complications but proper execution by the surgical team remains elusive. Objective: We ...
    • Remoteness and maternal and child health service utilization in rural Liberia: A population–based survey 

      Kenny, Avi; Basu, Gaurab; Ballard, Madeleine; Griffiths, Thomas; Kentoffio, Katherine; Niyonzima, Jean Bosco; Sechler, G. Andrew; Selinsky, Stephen; Panjabi, Rajesh R.; Siedner, Mark J.; Kraemer, John D. (Edinburgh University Global Health Society, 2015)
      Background: This study seeks to understand distance from health facilities as a barrier to maternal and child health service uptake within a rural Liberian population. Better understanding the relationship between distance ...
    • Removal of a Wire Brush Bristle from the Hypopharynx Using Suspension, Microscope, and Fluoroscopy 

      Naunheim, Matthew R.; Dedmon, Matthew M.; Mori, Matthew C.; Sedaghat, Ahmad R.; Dowdall, Jayme R. (Hindawi Publishing Corporation, 2015)
      Wire brush bristles are an increasingly recognized hazard that can present as a foreign body in the aerodigestive tract. Due to their small size and tendency to become embedded in surrounding tissue, these small metallic ...
    • Renal Cancer Resistance to Antiangiogenic Therapy Is Delayed by Restoration of Angiostatic Signaling 

      Bhatt, Rupal; Wang, Xiaoen; Zhang, Liang; Collins, M. P.; Signoretti, Sabina; Alsop, David; Goldberg, S. N.; Atkins, Michael; Mier, James (American Association for Cancer Research (AACR), 2010-08-10)
      Treatment of metastatic renal cell cancer (RCC) with antiangiogenic agents that block vascular endothelial growth factor (VEGF) receptor 2 signaling produces tumor regression in a substantial fraction of patients; however ...
    • Renal function estimation and Cockcroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: The Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives 

      Ferreira, João Pedro; Girerd, Nicolas; Pellicori, Pierpaolo; Duarte, Kevin; Girerd, Sophie; Pfeffer, Marc A.; McMurray, John J. V.; Pitt, Bertram; Dickstein, Kenneth; Jacobs, Lotte; Staessen, Jan A.; Butler, Javed; Latini, Roberto; Masson, Serge; Mebazaa, Alexandre; Rocca, Hans Peter Brunner-La; Delles, Christian; Heymans, Stephane; Sattar, Naveed; Jukema, J. Wouter; Cleland, John G.; Zannad, Faiez; Rossignol, Patrick (BioMed Central, 2016)
      Background: Renal impairment is a major risk factor for mortality in various populations. Three formulas are frequently used to assess both glomerular filtration rate (eGFR) or creatinine clearance (CrCl) and mortality ...
    • Renal Function Following Three Distinct Weight Loss Dietary Strategies During 2 Years of a Randomized Controlled Trial 

      Tirosh, Amir; Golan, Rachel; Harman-Boehm, Ilana; Henkin, Yaakov; Schwarzfuchs, Dan; Rudich, Assaf; Kovsan, Julia; Fiedler, Georg M.; Blüher, Matthias; Stumvoll, Michael; Thiery, Joachim; Stampfer, Meir J.; Shai, Iris (American Diabetes Association, 2013)
      OBJECTIVE This study addressed the long-term effect of various diets, particularly low-carbohydrate high-protein, on renal function on participants with or without type 2 diabetes. RESEARCH DESIGN AND METHODS In the 2-year ...
    • Renal Hyperfiltration and the Development of Microalbuminuria in Type 1 Diabetes 

      Ficociello, Linda Hanna; Perkins, Bruce A.; Roshan, Bijan; Weinberg, Janice M.; Aschengrau, Ann; Warram, James H.; Krolewski, Andrzej Stefan (American Diabetes Association, 2009)
      OBJECTIVE - The purpose of this study was to examine prospectively whether renal hyperfiltration is associated with the development of microalbuminuria in patients with type 1 diabetes, after taking into account known risk ...
    • Renal Intercalated Cells Sense and Mediate Inflammation via the P2Y14 Receptor 

      Azroyan, Anie; Cortez-Retamozo, Virna; Bouley, Richard; Liberman, Rachel; Ruan, Ye Chun; Kiselev, Evgeny; Jacobson, Kenneth A.; Pittet, Mikael J.; Brown, Dennis; Breton, Sylvie (Public Library of Science, 2015)
      Uncontrolled inflammation is one of the leading causes of kidney failure. Pro-inflammatory responses can occur in the absence of infection, a process called sterile inflammation. Here we show that the purinergic receptor ...
    • Renal Medullary and Cortical Correlates in Fibrosis, Epithelial Mass, Microvascularity, and Microanatomy Using Whole Slide Image Analysis Morphometry 

      Farris, Alton B.; Ellis, Carla L.; Rogers, Thomas E.; Lawson, Diane; Cohen, Cynthia; Rosen, Seymour (Public Library of Science, 2016)
      Renal tubulointerstitial injury often leads to interstitial fibrosis and tubular atrophy (IF/TA). IF/TA is typically assessed in the renal cortex and can be objectively quantitated with computerized image analysis (IA). ...
    • Renal Medullary Cancer in a Patient with Sickle Cell Trait 

      Alappan, Narendrakumar; Marak, Creticus P.; Chopra, Amit; Joy, Parijat S.; Dorokhova, Olena; Guddati, Achuta K. (Hindawi Publishing Corporation, 2013)
      Renal medullary cancer is a rare malignancy almost exclusively seen in young patients of African ethnicity. These patients often present with the cardinal symptoms of hematuria, flank pain, and an abdominal mass, and this ...
    • Reovirus Core Protein μ2 Determines the Filamentous Morphology of Viral Inclusion Bodies by Interacting with and Stabilizing Microtubules 

      Parker, John L.; Broering, Teresa J.; Kim, Jonghwa; Higgins, Darren E.; Nibert, Max L. (American Society for Microbiology, 2002)
      Cells infected with mammalian reoviruses often contain large perinuclear inclusion bodies, or "factories," where viral replication and assembly are thought to occur. Here, we report a viral strain difference in the morphology ...
    • Reovirus Outer Capsid Protein μ1 Induces Apoptosis and Associates with Lipid Droplets, Endoplasmic Reticulum, and Mitochondria 

      Coffey, Caroline M.; Sheh, Alexander; Kim, Irene S.; Chandran, Kartik; Nibert, Max L.; Parker, John L. (American Society for Microbiology, 2006)
      The mechanisms by which reoviruses induce apoptosis have not been fully elucidated. Earlier studies identified the mammalian reovirus S1 and M2 genes as determinants of apoptosis induction. However, no published results ...
    • Reovirus sigma NS protein localizes to inclusions through an association requiring the mu NS amino terminus. 

      Miller, Cathy L.; Broering, Teresa J.; Parker, John S. L.; Arnold, Michelle M.; Nibert, Max L. (American Society for Microbiology, 2003)
      Cells infected with mammalian reoviruses contain phase-dense inclusions, called viral factories, in which viral replication and assembly are thought to occur. The major reovirus nonstructural protein muNS forms morphologically ...
    • Reovirus μ1 Structural Rearrangements That Mediate Membrane Penetration 

      Zhang, Lan; Chandran, Kartik; Nibert, Max L.; Harrison, Stephen C. (American Society for Microbiology, 2006)
      Membrane penetration by nonenveloped reoviruses is mediated by the outer-capsid protein, mu 1 (76 kDa). Previous evidence has suggested that an autolytic cleavage in mu 1 allows the release of its N-terminally myristoylated ...
    • Repair of a bowel-containing, scrotal hernia with incarceration contributed by femorofemoral bypass graft 

      Sharma, Gaurav; Schouten, Jonathan A.; Itani, Kamal M. F. (Oxford University Press, 2016)
      The rising use of endovascular techniques utilizing femoral artery access may increase the frequency with which surgeons face the challenge of hernia repair in reoperative groins—which may or may not include a vascular ...
    • Repeat expansion and methylation state analysis with nanopore sequencing 

      Gießelmann, Pay; Brändl, Björn; Raimondeau, Etienne; Bowen, Rebecca; Rohrandt, Christian; Tandon, Rashmi; Kretzmer, Helene; Assum, Günter; Galonska, Christina; Siebert, Reiner; Ammerpohl, Ole; Heron, Andrew; Schneider, Susanne A.; Ladewig, Julia; Koch, Philipp; Schuldt, Bernhard M.; Graham, James E.; Meissner, Alexander; Müller, Franz-Josef (NPG, 2018-11-28)
      Expansions of short tandem repeats are genetic variants that have been implicated in neuropsychiatric and other disorders but their assessment remains challenging with current molecular methods. Here, we developed a ...
    • Repeat expansions confer WRN dependence in microsatellite-unstable cancers 

      van Wietmarschen, Niek; Sridharan, Sriram; Nathan, William J.; Tubbs, Anthony; Chan, Edmond; Callen, Elsa; Wu, Wei; Belinky, Frida; Tripathi, Veenu; Wong, Nancy; Foster, Kyla; Noorbakhsh, Javad; Garimella, Kiran; Cruz-Migoni, Abimael; Sommers, Joshua A.; Huang, Yongqing; Borah, Ashir A.; Smith, Jonathan T.; Kalfon, Jeremie; Kesten, Nikolas; Fugger, Kasper; Walker, Robert L.; Dolzhenko, Egor; Eberle, Michael A.; Hayward, Bruce E.; Usdin, Karen; Freudenreich, Catherine H.; Brosh, Robert M.; West, Stephen C.; McHugh, Peter J.; Meltzer, Paul S.; Bass, Adam; Nussenzweig, André (Springer Science and Business Media LLC, 2020-09-30)
      The RecQ DNA helicase WRN is a synthetic lethal target for cancer cells with microsatellite instability (MSI), a form of genetic hypermutability that arises from impaired mismatch repair. Depletion of WRN induces widespread ...