Browsing HMS Scholarly Articles by Title
Now showing items 1438-1457 of 17922
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Automated computation of arbor densities: a step toward identifying neuronal cell types
(Frontiers Media S.A., 2014)The shape and position of a neuron convey information regarding its molecular and functional identity. The identification of cell types from structure, a classic method, relies on the time-consuming step of arbor tracing. ... -
Automated De-Identification of Free-Text Medical Records
(BioMed Central, 2008)Background: Text-based patient medical records are a vital resource in medical research. In order to preserve patient confidentiality, however, the U.S. Health Insurance Portability and Accountability Act (HIPAA) requires ... -
Automated Decision-Support System for Prediction of Treatment Responders in Acute Ischemic Stroke
(Frontiers Media S.A., 2013)MRI is widely used in the assessment of acute ischemic stroke. In particular, it identifies the mismatch between hypoperfused and the permanently damaged tissue, the PWI-DWI mismatch volume. It is used to help triage ... -
Automated detection of missteps during community ambulation in patients with Parkinson’s disease: a new approach for quantifying fall risk in the community setting
(BioMed Central, 2014)Background: Falls are a leading cause of morbidity and mortality among older adults and patients with neurological disease like Parkinson’s disease (PD). Self-report of missteps, also referred to as near falls, has been ... -
Automated Detection of Near Falls: Algorithm Development and Preliminary Results
(BioMed Central, 2010)Background: Falls are a major source of morbidity and mortality among older adults. Unfortunately, self-report is, to a large degree, the gold-standard method for characterizing and quantifying fall frequency. A number of ... -
Automated Discovery of Functional Generality of Human Gene Expression Programs
(Public Library of Science, 2007)An important research problem in computational biology is the identification of expression programs, sets of co-expressed genes orchestrating normal or pathological processes, and the characterization of the functional ... -
Automated DNA Mutation Detection Using Universal Conditions Direct Sequencing: Application to Ten Muscular Dystrophy Genes
(BioMed Central, 2009)Background: One of the most common and efficient methods for detecting mutations in genes is PCR amplification followed by direct sequencing. Until recently, the process of designing PCR assays has been to focus on individual ... -
Automated grading system for evaluation of ocular redness associated with dry eye
(Dove Medical Press, 2013)Background: We have observed that dry eye redness is characterized by a prominence of fine horizontal conjunctival vessels in the exposed ocular surface of the interpalpebral fissure, and have incorporated this feature ... -
Automated Identification of Acute Hepatitis B Using Electronic Medical Record Data to Facilitate Public Health Surveillance
(Public Library of Science, 2008)Background: Automatic identification of notifiable diseases from electronic medical records can potentially improve the timeliness and completeness of public health surveillance. We describe the development and implementation ... -
Automated Methods for Surveillance of Surgical Site Infections
(Centers for Disease Control, 2001)Automated data, especially from pharmacy and administrative claims, are available for much of the U.S. population and might substantially improve both inpatient and postdischarge surveillance for surgical site infections ... -
Automated microfluidic platform of bead-based electrochemical immunosensor integrated with bioreactor for continual monitoring of cell secreted biomarkers
(Nature Publishing Group, 2016)There is an increasing interest in developing microfluidic bioreactors and organs-on-a-chip platforms combined with sensing capabilities for continual monitoring of cell-secreted biomarkers. Conventional approaches such ... -
Automated Modelling of Signal Transduction Networks
(BioMed Central, 2002)Background: Intracellular signal transduction is achieved by networks of proteins and small molecules that transmit information from the cell surface to the nucleus, where they ultimately effect transcriptional changes. ... -
Automated motion artifact removal for intravital microscopy, without a priori information
(Nature Publishing Group, 2014)Intravital fluorescence microscopy, through extended penetration depth and imaging resolution, provides the ability to image at cellular and subcellular resolution in live animals, presenting an opportunity for new insights ... -
Automated neuron tracking inside moving and deforming C. elegans using deep learning and targeted augmentation
(Springer Science and Business Media LLC, 2023-12-05)Recent advances allow sustained rapid 3D functional imaging of large numbers of neurons inside behaving animals. To decode neural activity, individual neurons must be segmented and tracked. This can be challenging inside ... -
Automated real time constant-specificity surveillance for disease outbreaks
(BioMed Central, 2007)Background: For real time surveillance, detection of abnormal disease patterns is based on a difference between patterns observed, and those predicted by models of historical data. The usefulness of outbreak detection ... -
Automated Screening of Microtubule Growth Dynamics Identifies MARK2 as a Regulator of Leading Edge Microtubules Downstream of Rac1 in Migrating Cells
(Public Library of Science, 2012)Polarized microtubule (MT) growth in the leading edge is critical to directed cell migration, and is mediated by Rac1 GTPase. To find downstream targets of Rac1 that affect MT assembly dynamics, we performed an RNAi screen ... -
Automated Sulcal Depth Measurement on Cortical Surface Reflecting Geometrical Properties of Sulci
(Public Library of Science, 2013)Sulcal depth that is one of the quantitative measures of cerebral cortex has been widely used as an important marker for brain morphological studies. Several studies have employed Euclidean (EUD) or geodesic (GED) algorithms ... -
Automated Synthesis and Visualization of a Chemotherapy Treatment Regimen Network
(2013)Cytotoxic treatments for cancer remain highly toxic, expensive, and variably efficacious. Many chemotherapy regimens are never directly compared in randomized clinical trials (RCTs); as a result, the vast majority of ... -
Automated Validation Of Genetic Variants From Large Databases: Ensuring That Variant References Refer To The Same Genomic Locations
(Oxford University Press, 2011)Accurate annotations of genomic variants are necessary to achieve full-genome clinical interpretations that are scientifically sound and medically relevant. Many disease associations, especially those reported before the ... -
Automated Vocabulary Discovery for Geo-Parsing Online Epidemic Intelligence
(BioMed Central, 2009)Background Automated surveillance of the Internet provides a timely and sensitive method for alerting on global emerging infectious disease threats. HealthMap is part of a new generation of online systems designed to monitor ...