Now showing items 1463-1482 of 17917

    • Automatic Verification of the Gradient Table in Diffusion-Weighted MRI Based on Fiber Continuity 

      Aganj, Iman (Springer Science and Business Media LLC, 2018-11-08)
      In diffusion-weighted magnetic resonance imaging (dMRI), the coordinate systems where the image and the diffusion gradients are represented may be inconsistent, thus impacting the quality of subsequent fiber tracking and ...
    • The Autonomic Brain: An Activation Likelihood Estimation Meta-Analysis for Central Processing of Autonomic Function 

      Beissner, Florian; Meissner, Karen; Bar, Karl-Jurgen; Napadow, Vitaly J. (Society for Neuroscience, 2013)
      The autonomic nervous system (ANS) is of paramount importance for daily life. Its regulatory action on respiratory, cardiovascular, digestive, endocrine, and many other systems is controlled by a number of structures in ...
    • Autonomic Dysregulation in Multiple Sclerosis 

      Pintér, Alexandra; Cseh, Domonkos; Sárközi, Adrienn; Illigens, Ben M.; Siepmann, Timo (MDPI, 2015)
      Multiple sclerosis (MS) is a chronic, progressive central neurological disease characterized by inflammation and demyelination. In patients with MS, dysregulation of the autonomic nervous system may present with various ...
    • Autonomic Effects of Controlled Fine Particulate Exposure in Young Healthy Adults: Effect Modification by Ozone 

      Fakhri, Asghar A.; Ilic, Ljubomir M.; Wellenius, Gregory A.; Urch, Bruce; Silverman, Frances; Gold, Diane R.; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2009)
      Background: Human controlled-exposure studies have assessed the impact of ambient fine particulate matter on cardiac autonomic function measured by heart rate variability (HRV), but whether these effects are modified by ...
    • The autonomic nervous system and renal physiology 

      D’Elia, John A; Weinrauch, Larry A (Dove Medical Press, 2013)
      Research in resistant hypertension has again focused on autonomic nervous system denervation – 50 years after it had been stopped due to postural hypotension and availability of newer drugs. These (ganglionic blockers) ...
    • Autonomous exoskeleton reduces metabolic cost of human walking during load carriage 

      Mooney, Luke M; Rouse, Elliott J; Herr, Hugh M (BioMed Central, 2014)
      Background: Many soldiers are expected to carry heavy loads over extended distances, often resulting in physical and mental fatigue. In this study, the design and testing of an autonomous leg exoskeleton is presented. The ...
    • Autonomous Sheet Pile Driving Robots for Soil Stabilization 

      Melenbrink, Nathan; Werfel, Justin (IEEE, 2019)
      Abstract— Soil stabilization is a fundamental component of nearly all construction projects, ranging from commercial construction to environmental restoration projects. Previous work in autonomous construction has generally ...
    • Autonomous Vascular Networks Synchronize GABA Neuron Migration in the Embryonic Forebrain 

      Won, Chungkil; Lin, Zhicheng; Kumar T, Peeyush; Li, Suyan; Ding, Lai; Elkhal, Abdallah; Szabó, Gábor; Vasudevan, Anju (2013)
      GABA neurons, born in remote germinative zones in the ventral forebrain (telencephalon), migrate tangentially in two spatially distinct streams to adopt their specific positions in the developing cortex. The cell types and ...
    • Autonomous Zinc-Finger Nuclease Pairs for Targeted Chromosomal Deletion 

      Şöllü, Cem; Pars, Kaweh; Cornu, Tatjana I.; Thibodeau-Beganny, Stacey; Maeder, Morgan L.; Joung, Jae Keith; Heilbronn, Regine; Cathomen, Toni (Oxford University Press, 2010)
      Zinc-finger nucleases (ZFNs) have been successfully used for rational genome engineering in a variety of cell types and organisms. ZFNs consist of a non-specific FokI endonuclease domain and a specific zinc-finger DNA-binding ...
    • Autopalmitoylation of TEAD Proteins Regulates Transcriptional Output of Hippo Pathway 

      Chan, PuiYee; Han, Xiao; Zheng, Baohui; DeRan, Michael; Yu, Jianzhong; Jarugumilli, Gopala K.; Deng, Hua; Pan, Duojia; Luo, Xuelian; Wu, Xu (2016)
      TEA domain (TEAD) transcription factors bind to the co-activator YAP/TAZ, and regulate the transcriptional output of Hippo pathway, playing critical roles in organ size control and tumorigenesis. Protein S-palmitoylation ...
    • Autophagic Cell Death and Apoptosis Jointly Mediate Cisatracurium Besylate-Induced Cell Injury 

      Zhuang, Haixia; Tian, Weili; Li, Wen; Zhang, Xingli; Wang, Jingjing; Yang, Yue; Liu, Xin; Xia, Zhengyuan; Feng, Du; Zhang, Liangqing (MDPI, 2016)
      Cisatracurium besylate is an ideal non-depolarizing muscle relaxant which is widely used in clinical application. However, some studies have suggested that cisatracurium besylate can affect cell proliferation. Moreover, ...
    • Autophagy Activation by Transcription Factor EB (TFEB) in Striatum of HDQ175/Q7 Mice 

      Vodicka, Petr; Chase, Kathryn; Iuliano, Maria; Tousley, Adelaide; Valentine, Dana T.; Sapp, Ellen; Kegel-Gleason, Kimberly B.; Sena-Esteves, Miguel; Aronin, Neil; DiFiglia, Marian (IOS Press, 2016)
      Background: Mutant huntingtin (mHTT) is encoded by the Huntington’s disease (HD) gene and its accumulation in the brain contributes to HD pathogenesis. Reducing mHTT levels through activation of the autophagosome-lysosomal ...
    • Autophagy Controls BCG-Induced Trained Immunity and the Response to Intravesical BCG Therapy for Bladder Cancer 

      Buffen, Kathrin; Oosting, Marije; Quintin, Jessica; Ng, Aylwin; Kleinnijenhuis, Johanneke; Kumar, Vinod; van de Vosse, Esther; Wijmenga, Cisca; van Crevel, Reinout; Oosterwijk, Egbert; Grotenhuis, Anne J.; Vermeulen, Sita H.; Kiemeney, Lambertus A.; van de Veerdonk, Frank L.; Chamilos, Georgios; Xavier, Ramnik J.; van der Meer, Jos W. M.; Netea, Mihai G.; Joosten, Leo A. B. (Public Library of Science, 2014)
      The anti-tuberculosis-vaccine Bacillus Calmette-Guérin (BCG) is the most widely used vaccine in the world. In addition to its effects against tuberculosis, BCG vaccination also induces non-specific beneficial effects against ...
    • Autophagy Correlates with the Therapeutic Responsiveness of Malignant Pleural Mesothelioma in 3D Models 

      Barbone, Dario; Follo, Carlo; Echeverry, Nohemy; Gerbaudo, Victor H.; Klabatsa, Astero; Bueno, Raphael; Felley-Bosco, Emanuela; Broaddus, V. Courtney (Public Library of Science, 2015)
      Malignant pleural mesothelioma is a highly chemoresistant solid tumor. We have studied this apoptotic resistance using in vitro and ex vivo three-dimensional models, which acquire a high level of chemoresistance that can ...
    • Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis 

      Wei, Jun; Long, Lingyun; Yang, Kai; Guy, Cliff; Shrestha, Sharad; Chen, Zuojia; Wu, Chuan; Vogel, Peter; Neale, Geoffrey; Green, Douglas R; Chi, Hongbo (2015)
      Regulatory T (Treg) cells respond to immune and inflammatory signals to mediate immunosuppression, but how functional integrity of Treg cells is maintained under activating environments remains elusive. Here we found that ...
    • Autophagy in Idiopathic Pulmonary Fibrosis 

      Patel, Avignat Suresh; Lin, Ling; Geyer, Alexander; Haspel, Jeffrey Adam; An, Chang Hyeok; Cao, Jiaofei; Rosas, Ivan O.; Morse, Danielle (Public Library of Science, 2012)
      Background: Autophagy is a basic cellular homeostatic process important to cell fate decisions under conditions of stress. Dysregulation of autophagy impacts numerous human diseases including cancer and chronic obstructive ...
    • Autophagy in Lysosomal Storage Disorders 

      Lieberman, Andrew P.; Puertollano, Rosa; Raben, Nina; Slaugenhaupt, Susan Ann; Walkley, Steven U.; Ballabio, Andrea (Landes Bioscience, 2012)
      Lysosomes are ubiquitous intracellular organelles that have an acidic internal pH, and play crucial roles in cellular clearance. Numerous functions depend on normal lysosomes, including the turnover of cellular constituents, ...
    • Autophagy in Neurodegenerative Diseases: From Mechanism to Therapeutic Approach 

      Nah, Jihoon; Yuan, Junying; Jung, Yong-Keun (Korean Society for Molecular and Cellular Biology, 2015)
      Autophagy is a lysosome-dependent intracellular degradation process that allows recycling of cytoplasmic constituents into bioenergetic and biosynthetic materials for maintenance of homeostasis. Since the function of ...
    • Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I 

      Yamamoto, Keisuke; Venida, Anthony; Yano, Julian; Biancur, Douglas E.; Kakiuchi, Miwako; Gupta, Suprit; Sohn, Albert S. W.; Mukhopadhyay, Subhadip; Lin, Elaine Y.; Parker, Seth J.; Banh, Robert S.; Paulo, Joao A.; Wen, Kwun Wah; Debnath, Jayanta; Kim, Grace E.; Mancias, Joseph D.; Fearon, Douglas T.; Perera, Rushika M.; Kimmelman, Alec C. (Springer Science and Business Media LLC, 2020-04-22)
      Immune evasion through impaired antigen presentation contributes to the growth and spread of many cancers1. Common mechanisms for immune evasion include mutations or loss of heterozygosity (LOH) of the major histocompatibility ...
    • Autoreactivity and Exceptional CDR Plasticity (but Not Unusual Polyspecificity) Hinder Elicitation of the Anti-HIV Antibody 4E10 

      Finton, Kathryn A. K.; Larimore, Kevin; Larman, H. Benjamin; Friend, Della; Correnti, Colin; Rupert, Peter B.; Elledge, Stephen J.; Greenberg, Philip D.; Strong, Roland K. (Public Library of Science, 2013)
      The broadly-neutralizing anti-HIV antibody 4E10 recognizes an epitope in the membrane-proximal external region of the HIV envelope protein gp41. Previous attempts to elicit 4E10 by vaccination with envelope-derived or ...