Browsing HMS Scholarly Articles by Title
Now showing items 14765-14784 of 17922
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The Role of Replicates for Error Mitigation in Next-Generation Sequencing
(Springer Science and Business Media LLC, 2014-01)Advances in next-generation technologies have rapidly improved sequencing fidelity and significantly decreased sequencing error rates. However, with billions of nucleotides in a human genome, even low experimental error ... -
The role of repressor kinetics in relief of transcriptional interference between convergent promoters
(Oxford University Press, 2016)Transcriptional interference (TI), where transcription from a promoter is inhibited by the activity of other promoters in its vicinity on the same DNA, enables transcription factors to regulate a target promoter indirectly, ... -
The role of retrieval inhibition in the associative memory impairment of schizophrenia
(Elsevier BV, 2007)To examine retrieval-induced forgetting (RIF) in schizophrenia, subjects studied category-exemplar words taken from either strong or weak categories, and then practiced retrieval by completing category word-stems on half ... -
The Role of Rhythm in Speech and Language Rehabilitation: The SEP Hypothesis
(Frontiers Media S.A., 2014)For thousands of years, human beings have engaged in rhythmic activities such as drumming, dancing, and singing. Rhythm can be a powerful medium to stimulate communication and social interactions, due to the strong ... -
The Role of RPE Cell-Associated VEGF189in Choroidal Endothelial Cell Transmigration across the RPE
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose. To determine the role of vascular endothelial growth factor 189 (VEGF189) in choroidal endothelial cell (CEC) migration across the retinal pigment epithelium (RPE) and to explore the molecular mechanisms ... -
The Role of SH3BP2 in the Pathophysiology of Cherubism
(BioMed Central, 2012)Cherubism is a rare bone dysplasia that is characterized by symmetrical bone resorption limited to the jaws. Bone lesions are filled with soft fibrous giant cell-rich tissue that can expand and cause severe facial deformity. ... -
The Role of Shear-Induced Transforming Growth Factor-? Signaling in the EndotheliumSignificance
(Ovid Technologies (Wolters Kluwer Health), 2013)Objective Vascular endothelial cells (ECs) are continuously exposed to blood flow that contributes to the maintenance of vessel structure and function; however, the effect of hemodynamic forces on transforming growth ... -
Role of shear-stress-induced VEGF expression in endothelial cell survival
(The Company of Biologists, 2012)Vascular endothelial growth factor (VEGF) plays a crucial role in developmental and pathological angiogenesis. Expression of VEGF in quiescent adult tissue suggests a potential role in the maintenance of mature blood ... -
Role of SHP-2 in Fibroblast Growth Factor Receptor-Mediated Suppression of Myogenesis in C2C12 Myoblasts
(American Society for Microbiology, 2002)Ligand activation of the fibroblast growth factor receptor (FGFR) represses myogenesis and promotes activation of extracellular signal-regulated kinases 1 and 2 (Erks). The precise mechanism through which the FGFR transmits ... -
The role of SIRT3 in regulating cancer cell metabolism
(BioMed Central, 2012) -
The role of sleep in bipolar disorder
(Dove Medical Press, 2016)Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative ... -
Role of spousal involvement in continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA)
(Southwest Journal of Pulmonary and Critical Care, 2017)INTRODUCTION: Little is known about the impact of spousal involvement on continuous positive airway pressure (CPAP) adherence. The aim of this study was to determine whether spouse involvement affects adherence with CPAP ... -
Role of spousal involvement in continuous positive airway pressure (CPAP) adherence in patients with obstructive sleep apnea (OSA)
(Southwest Journal of Pulmonary and Critical Care, 2017) -
Role of stromal cell-derived factor 1α pathway in bone metastatic prostate cancer
(Editorial Department of Journal of Biomedical Research, 2016)Abstract Metastatic prostate cancer is one of the leading causes of cancer-related death in men. The primary site of metastasis from prostate cancers is the bone. During the last decade, multiple studies have pointed to ... -
The Role of T Cells in Osteoporosis, an Update
(e-Century Publishing, 2009-05-20)Emerging evidence highlights the importance of the interplay between the bone and immune systems. That evidence bolsters a longstanding recognition that estrogen deficiency, infection, inflammation, and autoimmune disorders ... -
The Role of Tau in Neurodegenerative Diseases and Its Potential as a Therapeutic Target
(Hindawi Publishing Corporation, 2012)The abnormal deposition of proteins in and around neurons is a common pathological feature of many neurodegenerative diseases. Among these pathological proteins, the microtubule-associated protein tau forms intraneuronal ... -
Role of Tet proteins in enhancer activity and telomere elongation
(Cold Spring Harbor Laboratory Press, 2014)DNA methylation at the C-5 position of cytosine (5mC) is one of the best-studied epigenetic modifications and plays important roles in diverse biological processes. Iterative oxidation of 5mC by the ten-eleven translocation ... -
Role of Tet1 in genomic imprinting erasure
(2013)Genomic imprinting is an allele-specific gene expression system important for mammalian development and function 1. The molecular basis of genomic imprinting is allele-specific DNA methylation 1,2. While it is well known ... -
Role of Th17 cells in the immunopathogenesis of dry eye disease
(Springer Nature, 2009) -
Role of the Acidic Carboxyl-terminal Domain of the Single-stranded DNA-binding Protein of Bacteriophage T7 in Specific Protein-Protein Interactions
(American Society for Biochemistry and Molecular Biology, 1998)The gene 2.5 single-stranded DNA (ssDNA) binding protein of bacteriophage T7 is essential for T7 DNA replication and recombination, Earlier studies have shown that the COOH-terminal 21 amino acids of the gene 2.5 protein ...