Browsing HMS Scholarly Articles by Title
Now showing items 14805-14824 of 17921
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Role of Wall Teichoic Acids in Staphylococcus aureus Endophthalmitis
(Association for Research in Vision and Ophthalmology (ARVO), 2011)Purpose: Wall teichoic acids (WTAs) are major polyanionic polymer components of the cell wall of Staphylococcus aureus. However, little is known about their role at the host–pathogen interface, especially in endophthalmitis. ... -
The role of whole brain radiation therapy in the management of melanoma brain metastases
(BioMed Central, 2014)Background: Brain metastases are common in patients with melanoma, and optimal management is not well defined. As melanoma has traditionally been thought of as “radioresistant,” the role of whole brain radiation therapy ... -
The Role Played by Cell-Substrate Interactions in the Pathogenesis of Osteoclast-Mediated Peri-Implant Osteolysis
(BioMed Central, 2006)Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particles released from the implant components induce a granulomatous ... -
Roles for the Conserved Spc105p/Kre28p Complex in Kinetochore-Microtubule Binding and the Spindle Assembly Checkpoint
(Public Library of Science, 2009)Background: Kinetochores attach sister chromatids to microtubules of the mitotic spindle and orchestrate chromosome disjunction at anaphase. Although S. cerevisiae has the simplest known kinetochores, they nonetheless ... -
Roles for VEGF in the adult
(Elsevier BV, 2007)The role of VEGF during development and in pathology is well known, but its function in normal adult tissues is poorly understood. Adverse effects associated with the use of anti-angiogenic therapies targeting VEGF in human ... -
The roles of long noncoding RNA in epigenetic regulation
(BioMed Central, 2013) -
Roles of Major Facilitator Superfamily Transporters in Phosphate Response in \(Drosophila\)
(Public Library of Science, 2012)The major facilitator superfamily (MFS) transporter \(Pho84\) and the type III transporter \(Pho84\) are responsible for metabolic effects of inorganic phosphate in yeast. While the \(Pho84\) ortholog Pit1 was also shown ... -
Roles of Nurse Practitioners and Physician Assistants in Rheumatology Practices in the US
(Wiley-Blackwell, 2014)Background—A recent workforce study of rheumatology in the US suggests that during the next several decades the demand for rheumatology services will outstrip the supply of rheumatologists. Mid-level providers such as nurse ... -
Roles of Piwi Proteins in Transcriptional Regulation Mediated by HP1s in Cultured Silkworm Cells
(Public Library of Science, 2014)Piwi proteins are part of a superfamily of Argonaute proteins, which are one of the core components of the RNA silencing pathway in many eukaryotes. Piwi proteins are thought to repress the transposon expression both ... -
The roles of senior management in improving hospital experiences for frail older adults
(Cengage Learning, Inc., 2006) -
The Roles of Streptozotocin Neurotoxicity and Neutral Endopeptidase in Murine Experimental Diabetic Neuropathy
(Hindawi Publishing Corporation, 2009)We demonstrated that inhibition of neutral endopeptidase (NEP), a protease that degrades vaso- and neuroactive peptides, improves vascular and neural function in diabetic animal models. In this study we explored the role ... -
Roles of the Nuclear Lamina in Stable Nuclear Association and Assembly of a Herpesviral Transactivator Complex on Viral Immediate-Early Genes
(American Society for Microbiology, 2012)ABSTRACT: Little is known about the mechanisms of gene targeting within the nucleus and its effect on gene expression, but most studies have concluded that genes located near the nuclear periphery are silenced by ... -
Roles of Thrombospondin-1 and -2 in Regulating Corneal and Iris Angiogenesis
(Association for Research in Vision and Ophthalmology (ARVO), 2004)purpose. Thrombospondin (TSP)-1 and -2 are important antiangiogenic factors thought to be involved in maintaining corneal avascularity (angiogenic privilege). This study was undertaken to investigate whether deficiencies ... -
The Roles of Transmembrane Domain Helix-III during Rhodopsin Photoactivation
(Public Library of Science, 2011)Background: Rhodopsin, the prototypic member of G protein-coupled receptors (GPCRs), undergoes isomerization of 11-cis-retinal to all-trans-retinal upon photoactivation. Although the basic mechanism by which rhodopsin is ... -
The Roles of VHL-Dependent Ubiquitination in Signaling and Cancer
(Frontiers Research Foundation, 2012)The function of tumor suppressor VHL is compromised in the vast majority of clear cell renal cell carcinoma, and its mutations or loss of expression was causal for this disease. pVHL was found to be a substrate recognition ... -
Romantic Love Is Associated with Enhanced Inhibitory Control in an Emotional Stop-Signal Task
(Frontiers Media S.A., 2016)Purpose: This study explored whether romantic lovers differ in emotion-related inhibitory control capacity from those who are single. Methods: 88 healthy undergraduate college students participated in the study. Half were ... -
ROS-GC interlocked Ca2+-sensor S100B protein signaling in cone photoreceptors: review
(Frontiers Media S.A., 2014)Photoreceptor rod outer segment membrane guanylate cyclase (ROS-GC) is central to visual transduction; it generates cyclic GMP, the second messenger of the photon signal. Photoexcited rhodopsin initiates a biochemical ... -
ROS1 Immunohistochemistry for Detection of ROS1-Rearranged Lung Adenocarcinomas
(Ovid Technologies (Wolters Kluwer Health), 2013)ROS1 gene rearrangements are reported in 1–2% of lung adenocarcinomas (ACA) and are associated with response to the multitargeted tyrosine kinase inhibitor, crizotinib. ROS1 rearrangements can be detected using fluorescence ... -
Rosiglitazone and Myocardial Infarction in Patients Previously Prescribed Metformin
(Public Library of Science, 2009)Objective: Rosiglitazone was found associated with approximately a 43% increase in risk of acute myocardial infarction (AMI) in a two meta-analyses of clinical trials. Our objective is to estimate the magnitude of the ... -
Rosuvastatin for primary prevention in patients with European systematic coronary risk evaluation risk ≥5% or Framingham risk >20%: post hoc analyses of the JUPITER trial requested by European health authorities
(Oxford University Press, 2010)Aims: On the basis of the JUPITER trial, European health authorities recently approved the use of rosuvastatin to reduce first major cardiovascular events among ‘high' global risk primary prevention patients defined either ...