Browsing HMS Scholarly Articles by Title

Now showing items 15477-15496 of 17922

    • Small-molecule inhibition of BRD4 as a new potent approach to eliminate leukemic stem- and progenitor cells in acute myeloid leukemia (AML) 

      Herrmann, Harald; Blatt, Katharina; Shi, Junwei; Gleixner, Karoline V.; Cerny-Reiterer, Sabine; Müllauer, Leonhard; Vakoc, Christopher R.; Sperr, Wolfgang R.; Horny, Hans-Peter; Bradner, James E.; Zuber, Johannes; Valent, Peter (Impact Journals LLC, 2012)
      Acute myeloid leukemia (AML) is a life-threatening stem cell disease characterized by uncontrolled proliferation and accumulation of myeloblasts. Using an advanced RNAi screen-approach in an AML mouse model we have recently ...

    • Small-Molecule Inhibitors of Dengue-Virus Entry 

      Schmidt, Aaron Gregory; Lee, Kyungae; Yang, Priscilla; Harrison, Stephen C. (Public Library of Science, 2012)
      Flavivirus envelope protein (E) mediates membrane fusion and viral entry from endosomes. A low-pH induced, dimer-to-trimer rearrangement and reconfiguration of the membrane-proximal "stem" of the E ectodomain draw together ...

    • Small-Molecule Screen Identifies Reactive Oxygen Species as Key Regulators of Neutrophil Chemotaxis 

      Hattori, Hidenori; Subramanian, Kulandayan K.; Sakai, Jiro; Jia, Yonghui; Li, Yitang; Porter, Timothy F.; Loison, Fabien; Sarraj, Bara; Kasorn, Anongnard; Jo, Hakryul; Blanchard, Catlyn; Zirkle, Dorothy; McDonald, Douglas Ray; Pai, Sung-Yun; Serhan, Charles Nicholas; Luo, Hongbo (Proceedings of the National Academy of Sciences, 2010)
      Neutrophil chemotaxis plays an essential role in innate immunity, but the underlying cellular mechanism is still not fully characterized. Here, using a small-molecule functional screening, we identified NADPH oxidase–dependent ...

    • Small-Molecule Targeting of Brachyury Transcription Factor Addiction in Chordoma 

      Sharifnia, Tanaz; Wawer, Mathias J.; Chen, Ting; Huang, Qing-Yuan; Weir, Barbara A.; Sizemore, Ann; Lawlor, Matthew A.; Goodale, Amy; Cowley, Glenn S.; Vazquez, Francisca; Ott, Christopher; Francis, Joshua M.; Sassi, Slim; Cogswell, Patricia; Sheppard, Hadley E.; Zhang, Tinghu; Gray, Nathanael; Clarke, Paul A.; Blagg, Julian; Workman, Paul; Sommer, Josh; Hornicek, Francis; Root, David E.; Hahn, William; Bradner, James E.; Wong, Kwok-Kin; Clemons, Paul A.; Lin, Charles Y.; Kotz, Joanne D.; Schreiber, Stuart (Springer Science and Business Media LLC, 2019-01-21)
      Chordoma is a primary bone cancer with no approved therapy. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic mutations in ...

    • Small-molecule targeting of translation initiation for cancer therapy 

      Aktas, Bertal H.; Qiao, Yuan; Ozdelen, Esra; Schubert, Roland; Sevinc, Sema; Harbinski, Fred; Grubissich, Luciano; Singer, Samuel; Halperin, Jose A. (Impact Journals LLC, 2013)
      Translation initiation plays a critical role in the regulation of cell growth and tumorigenesis. We report here that inhibiting translation initiation through induction of eIF2α phosphorylation by small-molecular-weight ...

    • Small-molecule-induced polymerization triggers degradation of BCL6 

      Słabicki, Mikołaj; Yoon, Hojong; Koeppel, Jonas; Nitsch, Lena; Roy Burman, Shourya; Di Genua, Cristina; Donovan, Katherine A.; Sperling, Adam S.; Hunkeler, Moritz; Tsai, Jonathan M.; Sharma, Rohan; Guirguis, Andrew; Zou, Charles; Chudasama, Priya; Gasser, Jessica A.; Miller, Peter G.; Scholl, Claudia; Fröhling, Stefan; Nowak, Radosław P.; Fischer, Eric S.; Ebert, Benjamin L. (Springer Science and Business Media LLC, 2020-11-18)
      Effective and sustained inhibition of non-enzymatic oncogenic driver proteins represents a major pharmacologic challenge. The clinical success of thalidomide analogs demonstrates the therapeutic efficacy of drug-induced ...

    • Smaller hippocampal volume predicts pathologic vulnerability to psychological trauma 

      Gilbertson, Mark; Shenton, Martha Elizabeth; Ciszewski, Aleksandra; Kasai, Kiyoto; Lasko, Natasha B.; Orr, Scott P.; Pitman, roger Keith (Nature Publishing Group, 2002)
      In animals, exposure to severe stress can damage the hippocampus. Recent human studies show smaller hippocampal volume in individuals with the stress-related psychiatric condition posttraumatic stress disorder (PTSD). Does ...

    • Smaller Left Heschl’s Gyrus Volume in Patients With Schizotypal Personality Disorder 

      Dickey, Chandlee C.; McCarley, Robert William; Voglmaier, Martina M.; Frumin, Melissa; Niznikiewicz, Margaret A.; Hirayasu, Yoshio; Fraone, Stephanie; Seidman, Larry Joel; Shenton, Martha Elizabeth (American Psychiatric Publishing, 2002)
      Objective: Individuals with schizophrenia spectrum disorders evince similar genetic, neurotransmitter, neuropsychological, electrophysiological, and structural abnormalities. Magnetic resonance imaging (MRI) studies have ...

    • Smaller Neocortical Gray Matter and Larger Sulcal Cerebrospinal Fluid Volumes in Neuroleptic-Naive Women With Schizotypal Personality Disorder 

      Koo, Min-Seong; Dickey, Chandlee C.; Park, Hae-Jeong; Kubicki, Marek R.; Ji, Na Young; Bouix, Sylvain; Pohl, Kilian M.; Levitt, James Jonathan; Nakamura, Motoaki; Shenton, Martha Elizabeth; McCarley, Robert William (American Medical Association (AMA), 2006)
      Context: Structural brain abnormalities, including larger cerebrospinal fluid (CSF) volumes, have been observed in men diagnosed as having schizotypal personality disorder (SPD). Objectives: To determine whether women ...

    • Smart Micro/nanoparticles in Stimulus-Responsive Drug/gene Delivery Systems 

      Karimi, Mahdi; Ghasemi, Amir; Sahandi Zangabad, Parham; Rahighi, Reza; Moosavi Basri, S. Masoud; Mirshekari, H.; Amiri, M.; Shafaei Pishabad, Z.; Aslani, A.; Bozorgomid, M.; Ghosh, D.; Beyzavi, A.; Vaseghi, A.; Aref, A. R.; Haghani, L.; Bahrami, S.; Hamblin, Michael (Royal Society of Chemistry (RSC), 2016)
      New achievements in the realm of nanoscience and innovative techniques of nanomedicine have moved micro/nanoparticles (MNPs) to the point of becoming actually useful for practical applications in the near future. Various ...

    • The SMART Platform: early experience enabling substitutable applications for electronic health records 

      Mandl, Kenneth David; Mandel, Joshua; Murphy, Shawn Norman; Bernstam, Elmer Victor; Ramoni, Rachel L; Kreda, David A; McCoy, J. Michael; Adida, Ben; Kohane, Isaac Samuel (BMJ Group, 2012)
      Objective: The Substitutable Medical Applications, Reusable Technologies (SMART) Platforms project seeks to develop a health information technology platform with substitutable applications (apps) constructed around core ...

    • Smart-Phone Based Magnetic Levitation for Measuring Densities 

      Knowlton, Stephanie; Yu, Chu Hsiang; Jain, Nupur; Ghiran, Ionita Calin; Tasoglu, Savas (Public Library of Science, 2015)
      Magnetic levitation, which uses a magnetic field to suspend objects in a fluid, is a powerful and versatile technology. We develop a compact magnetic levitation platform compatible with a smart-phone to separate micro-objects ...

    • Smart-RRBS for single-cell methylome and transcriptome analysis 

      Gu, Hongcang; Raman, Ayush T.; Wang, Xiaoxue; Gaiti, Federico; Chaligne, Ronan; Mohammad, Arman W.; Arczewska, Aleksandra; Smith, Zachary D.; Landau, Dan A.; Aryee, Martin; Meissner, Alexander; Gnirke, Andreas; Raman, Ayush (Springer Science and Business Media LLC, 2021-07-09)

    • Smartphone-Based Fluorescent Diagnostic System for Highly Pathogenic H5N1 Viruses 

      Yeo, Seon-Ju; Choi, Kyunghan; Cuc, Bui Thi; Hong, Nguyen Ngoc; Bao, Duong Tuan; Ngoc, Nguyen Minh; Le, Mai Quynh; Hang, Nguyen Le Khanh; Thach, Nguyen Co; Mallik, Shyam Kumar; Kim, Hak Sung; Chong, Chom-Kyu; Choi, Hak Soo; Sung, Haan Woo; Yu, Kyoungsik; Park, Hyun (Ivyspring International Publisher, 2016)
      Field diagnostic tools for avian influenza (AI) are indispensable for the prevention and controlled management of highly pathogenic AI-related diseases. More accurate, faster and networked on-site monitoring is demanded ...

    • Smartphone-Based Psychotherapeutic Micro-Interventions to Improve Mood in a Real-World Setting 

      Meinlschmidt, Gunther; Lee, Jong-Hwan; Stalujanis, Esther; Belardi, Angelo; Oh, Minkyung; Jung, Eun Kyung; Kim, Hyun-Chul; Alfano, Janine; Yoo, Seung-Schik; Tegethoff, Marion (Frontiers Media S.A., 2016)
      Background: Using mobile communication technology as new personalized approach to treat mental disorders or to more generally improve quality of life is highly promising. Knowledge about intervention components that target ...

    • Smear positivity in paediatric and adult tuberculosis: systematic review and meta-analysis 

      Kunkel, Amber; Abel zur Wiesch, Pia; Nathavitharana, Ruvandhi R.; Marx, Florian M.; Jenkins, Helen E.; Cohen, Ted (BioMed Central, 2016)
      Background: Tuberculosis (TB) diagnosis continues to rely on sputum smear microscopy in many settings. We conducted a meta-analysis to estimate the percentage of children and adults with tuberculosis that are sputum smear ...

    • SMI Life Goals: Description of a randomized trial of a Collaborative Care Model to improve outcomes for persons with serious mental illness 

      Kilbourne, Amy M.; Bramlet, Margretta; Barbaresso, Michelle M.; Nord, Kristina M.; Goodrich, David E.; Lai, Zongshan; Post, Edward P.; Almirall, Daniel; Verchinina, Lilia; Duffy, Sonia A.; Bauer, Mark S (Elsevier BV, 2014)
      Background Persons with serious mental illnesses (SMI) are more likely to die earlier than the general population, primarily due to increased medical burden, particularly from cardiovascular disease (CVD). Life Goals ...

    • Smoke-free legislation and the incidence of paediatric respiratory infections and wheezing/asthma: interrupted time series analyses in the four UK nations 

      Been, Jasper V.; Szatkowski, Lisa; van Staa, Tjeerd-Pieter; Leufkens, Hubert G.; van Schayck, Onno C.; Sheikh, Aziz; de Vries, Frank; Souverein, Patrick (Nature Publishing Group, 2015)
      We investigated the association between introduction of smoke-free legislation in the UK (March 2006 for Scotland, April 2007 for Wales and Northern Ireland, and July 2007 for England) and the incidence of respiratory ...

    • Smoker's Paradox in Patients With ST‐Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention 

      Gupta, Tanush; Kolte, Dhaval; Khera, Sahil; Harikrishnan, Prakash; Mujib, Marjan; Aronow, Wilbert S.; Jain, Diwakar; Ahmed, Ali; Cooper, Howard A.; Frishman, William H.; Bhatt, Deepak L.; Fonarow, Gregg C.; Panza, Julio A. (Wiley-Blackwell, 2016)
      Background: Prior studies have found that smokers undergoing thrombolytic therapy for ST‐segment elevation myocardial infarction have lower in‐hospital mortality than nonsmokers, a phenomenon called the “smoker's paradox.” ...

    • Smoking is associated with the concurrent presence of multiple autoantibodies in rheumatoid arthritis rather than with anti-citrullinated protein antibodies per se: a multicenter cohort study 

      van Wesemael, Tineke J.; Ajeganova, Sofia; Humphreys, Jennifer; Terao, Chikashi; Muhammad, Ammar; Symmons, Deborah P. M.; MacGregor, Alex J.; Hafström, Ingiäld; Trouw, Leendert A.; van der Helm-van Mil, Annette H. M.; Huizinga, Tom W. J.; Mimori, Tsuneyo; Toes, René E. M.; Matsuda, Fumihiko; Svensson, Björn; Verstappen, Suzanne M. M.; van der Woude, Diane (BioMed Central, 2016)
      Background: The contribution of smoking to rheumatoid arthritis (RA) is hypothesized to be mediated through formation of anti-citrullinated protein antibodies (ACPA). In RA, however, autoantibodies such as ACPA, rheumatoid ...