Now showing items 1777-1796 of 17917

    • Blocking p62-dependent SMN degradation ameliorates spinal muscular atrophy disease phenotypes 

      Rodriguez-Muela, Natalia; Parkhitko, Andrey; Grass, Tobias; Gibbs, Rebecca; Norabuena, Erika M.; Perrimon, Norbert; Singh, Rajat; Rubin, Lee (American Society for Clinical Investigation, 2018-06-11)
      Spinal muscular atrophy (SMA), a degenerative motor neuron (MN) disease, caused by loss of functional survival of motor neuron (SMN) protein due to SMN1 gene mutations, is a leading cause of infant mortality. Increasing ...
    • Blocking the formation of radiation–induced breast cancer stem cells 

      Wang, Yangyang; Li, Wende; Patel, Shalin S.; Cong, Juan; Zhang, Nan; Sabbatino, Francesco; Liu, Xiaoyan; Qi, Yuan; Huang, Peigen; Lee, Hang; Taghian, Alphonse; Li, Jian-Jian; DeLeo, Albert B.; Ferrone, Soldano; Epperly, Michael W.; Ferrone, Cristina R.; Ly, Amy; Brachtel, Elena F.; Wang, Xinhui (Impact Journals LLC, 2014)
      The goal of adjuvant (post-surgery) radiation therapy (RT) for breast cancer (BC) is to eliminate residual cancer cells, leading to better local tumor control and thus improving patient survival. However, radioresistance ...
    • Blood Accessibility to Fibrin in Venous Thrombosis is Thrombus Age-Dependent and Predicts Fibrinolytic Efficacy: An In Vivo Fibrin Molecular Imaging Study 

      Stein-Merlob, Ashley F.; Kessinger, Chase W.; Erdem, S. Sibel; Zelada, Henry; Hilderbrand, Scott A.; Lin, Charles P.; Tearney, Guillermo J.; Jaff, Michael R.; Reed, Guy L.; Henke, Peter K.; McCarthy, Jason R.; Jaffer, Farouc A. (Ivyspring International Publisher, 2015)
      Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ...
    • Blood and War 

      Hedley-Whyte, John; Milamed, Debra (The Ulster Medical Society, 2010)
      In 1894 Ulsterman and pathologist Almroth Wright described the citation of blood. Twenty-one years later it was introduced into wartime and clinical practice. Harvard Medical School had a large part in providing Colonel ...
    • Blood Banking in Living Droplets 

      Samot, Josh; Moon, Sangjun; Shao, Lei; Zhang, Xiaohui; Xu, Feng; Song, YoungSeok; Keles, Hasan Onur; Matloff, Laura; Markel, Jordan; Demirci, Utkan (Public Library of Science, 2011)
      Blood banking has a broad public health impact influencing millions of lives daily. It could potentially benefit from emerging biopreservation technologies. However, although vitrification has shown advantages over traditional ...
    • Blood Donation and Colorectal Cancer Incidence and Mortality in Men 

      Zhang, Xuehong; Ma, Jing; Wu, Kana; Chan, Andrew Tan; Fuchs, Charles Stewart; Giovannucci, Edward L. (Public Library of Science, 2012)
      Background: Although blood donations may reduce body iron stores, to date, prospective data on frequent blood donation and colorectal cancer risk are limited. Methodology/Principal Findings: We tested whether frequent ...
    • Blood Epigenetic Age may Predict Cancer Incidence and Mortality 

      Zheng, Yinan; Joyce, Brian T.; Colicino, Elena; Liu, Lei; Zhang, Wei; Dai, Qi; Shrubsole, Martha J.; Kibbe, Warren A.; Gao, Tao; Zhang, Zhou; Jafari, Nadereh; Vokonas, Pantel; Schwartz, Joel; Baccarelli, Andrea A.; Hou, Lifang (Elsevier, 2016)
      Biological measures of aging are important for understanding the health of an aging population, with epigenetics particularly promising. Previous studies found that tumor tissue is epigenetically older than its donors are ...
    • Blood Group, Immunity, and Risk of Infection with Vibrio cholerae in an Area of Endemicity 

      Harris, Jason B.; Khan, Ashraful I.; LaRocque, Regina C.; Dorer, David J.; Chowdhury, Fahima; Faruque, Abu G.; Sack, David A.; Ryan, Edward T.; Qadri, Firdausi; Calderwood, Stephen B. (American Society for Microbiology, 2005)
      Individuals with blood group O are more susceptible than other individuals to severe cholera, although the mechanism underlying this association is unknown. To assess the respective roles of both intrinsic host factors and ...
    • Blood Lead Levels and Serum Insulin-Like Growth Factor 1 Concentrations in Peripubertal Boys 

      Fleisch, Abby F.; Burns, Jane S.; Williams, Paige L.; Lee, Mary M.; Sergeyev, Oleg; Korrick, Susan A.; Hauser, Russ (National Institute of Environmental Health Sciences, 2013)
      Background: Childhood lead exposure has been associated with growth delay. However, the association between blood lead levels (BLLs) and insulin-like growth factor 1 (IGF-1) has not been characterized in a large cohort ...
    • Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice 

      Schoretsanitis, Georgios; Kane, John M.; Correll, Christoph U.; Marder, Stephen R.; Citrome, Leslie; Newcomer, John W.; Robinson, Delbert G.; Goff, Donald C.; Kelly, Deanna L.; Freudenreich, Oliver; Piacentino, Daria; Paulzen, Michael; Conca, Andreas; Zernig, Gerald; Haen, Ekkehard; Baumann, Pierre; Hiemke, Christoph; Gründer, Gerhard (Physicians Postgraduate Press, Inc, 2020-05-19)
    • Blood Levels to Optimize Antipsychotic Treatment in Clinical Practice; a Joint Consensus Statement of the American Society of Clinical Psychopharmacology (ASCP) and the Therapeutic Drug Monitoring (TDM) Task Force of the Arbeitsgemeinschaft Für Neuropsychopharmakologie Und Pharmakopsychiatrie (AGNP) 

      Schoretsanitis, Georgios; Kane, John; Correll, Christoph U.; Marder, Stephen R.; Citrome, Leslie; Newcomer, John W.; Robinson, Delbert G.; Goff, Donald; Kelly, Deanna L.; Freudenreich, Oliver; Piacentino, Daria; Paulzen, Michael; Conca, Andreas; Zernig, Gerald; Haen, Ekkehard; Baumann, Pierre; Hiemke, Christoph; Gründer, Gerhard (Physicians Postgraduate Press, Inc, 2020-05-19)
      Objective The quantification of antipsychotic levels in blood, also known as therapeutic drug monitoring (TDM), is a potentially useful tool of modern personalized therapy that can be applied to augment antipsychotic use ...
    • Blood Oxygen Depletion Is Independent of Dive Function in a Deep Diving Vertebrate, the Northern Elephant Seal 

      Meir, Jessica U.; Robinson, Patrick W.; Vilchis, L. Ignacio; Kooyman, Gerald L.; Costa, Daniel P.; Ponganis, Paul J. (Public Library of Science, 2013)
      Although energetics is fundamental to animal ecology, traditional methods of determining metabolic rate are neither direct nor instantaneous. Recently, continuous blood oxygen (O2) measurements were used to assess energy ...
    • Blood pool contrast agents for venous magnetic resonance imaging 

      Oliveira, Irai S.; Hedgire, Sandeep Subhash; Li, Weier; Ganguli, Suvranu; Prabhakar, Anand M (AME Publishing Company, 2016)
      Imaging of the venous system plays a vital role in the diagnosis and management of a wide range of clinically significant disorders. There have been great advances in venous imaging techniques, culminating in the use of ...
    • Blood Pressure Changes in Relation to Arsenic Exposure in a U.S. Pregnancy Cohort 

      Farzan, Shohreh F.; Chen, Yu; Wu, Fen; Jiang, Jieying; Liu, Mengling; Baker, Emily; Korrick, Susan A.; Karagas, Margaret R. (NLM-Export, 2015)
      Background: Inorganic arsenic exposure has been related to the risk of increased blood pressure based largely on cross-sectional studies conducted in highly exposed populations. Pregnancy is a period of particular vulnerability ...
    • Blood Pressure Elevation Associated with Sleep-Related Breathing Disorder in a Community Sample of White and Hispanic Children 

      Enright, Paul L.; Goodwin, James L.; Sherrill, Duane L.; Quan, Jeremy R.; Quan, Stuart (American Medical Association (AMA), 2003-09-01)
      Background: The Tucson Children's Assessment of Sleep Apnea study (TuCASA) was designed to investigate the prevalence and correlates of objectively measured sleep-related breathing disorder (SBD) in preadolescent Hispanic ...
    • Blood Pressure Variability and Closed-Loop Baroreflex Assessment in Adolescent Chronic Fatigue Syndrome During Supine Rest and Orthostatic Stress 

      Wyller, Vegard Bruun; Barbieri, Riccardo; Saul, J. Philip (Springer-Verlag, 2010)
      Hemodynamic abnormalities have been documented in the chronic fatigue syndrome (CFS), indicating functional disturbances of the autonomic nervous system responsible for cardiovascular regulation. The aim of this study was ...
    • Blood RNA biomarker panel detects both left- and right-sided colorectal neoplasms: a case-control study 

      Chao, Samuel; Ying, Jay; Liew, Gailina; Marshall, Wayne; Liew, Choong-Chin; Burakoff, Robert (BioMed Central, 2013)
      Background: Colonoscopy is widely regarded to be the gold standard for colorectal cancer (CRC) detection. Recent studies, however, suggest that the effectiveness of colonoscopy is mostly confined to tumors on the left side ...
    • Blood Telomere Length Attrition and Cancer Development in the Normative Aging Study Cohort 

      Hou, Lifang; Joyce, Brian Thomas; Gao, Tao; Liu, Lei; Zheng, Yinan; Penedo, Frank J.; Liu, Siran; Zhang, Wei; Bergan, Raymond; Dai, Qi; Vokonas, Pantel; Hoxha, Mirjam; Schwartz, Joel; Baccarelli, Andrea (Elsevier, 2015)
      Background: Accelerated telomere shortening may cause cancer via chromosomal instability, making it a potentially useful biomarker. However, publications on blood telomere length (BTL) and cancer are inconsistent. We ...
    • Blood Transfusion Effects in Kidney Transplantation 

      Carpenter, Charles Bernard (Yale Journal of Biology and Medicine, 1990)
      Within the three decades since the beginnings of the field of clinical renal transplantation there have been four phases in blood transfusion policies, swinging from liberal transfusions to avoidance of transfusions, ...
    • Blood vessel maturation: vascular development comes of age 

      Darland, Diane C.; D'Amore, Patricia Ann (American Society for Clinical Investigation, 1999)