Browsing HMS Scholarly Articles by Title

Now showing items 1871-1890 of 17922

    • The Brain Metabolome of Male Rats across the Lifespan 

      Zheng, Xiaojiao; Chen, Tianlu; Zhao, Aihua; Wang, Xiaoyan; Xie, Guoxiang; Huang, Fengjie; Liu, Jiajian; Zhao, Qing; Wang, Shouli; Wang, Chongchong; Zhou, Mingmei; Panee, Jun; He, Zhigang; Jia, Wei (Nature Publishing Group, 2016)
      Comprehensive and accurate characterization of brain metabolome is fundamental to brain science, but has been hindered by technical limitations. We profiled the brain metabolome in male Wistar rats at different ages (day ...

    • Brain metastases in patients with EGFR -mutated or ALK -rearranged non-small-cell lung cancers 

      Rangachari, Deepa; Yamaguchi, Norihiro; Vanderlaan, Paul A; Folch, Erik E; Mahadevan, Anand; Floyd, Scott R.; Uhlmann, Erik J; Wong, Eric S.; Dahlberg, Suzanne Eleanor; Huberman, Mark S.; Costa, Daniel Botelho (Elsevier BV, 2015)
      Introduction—Brain metastases (BM) are common in non-small-cell lung cancer (NSCLC). However, the baseline incidence and evolution of BM over time in oncogene-driven NSCLCs are seldom reported. In this study, we evaluated ...

    • Brain MR Imaging at Ultra-Low Radiofrequency Power 

      Sarkar, Subhendra N.; Alsop, David; Madhuranthakam, Ananth J.; Busse, Reed F.; Robson, Philip M.; Rofsky, Neil M.; Hackney, David (Radiological Society of North America (RSNA), 2011-05)
      Purpose: To explore the lower limits for radiofrequency (RF) power-induced specific absorption rate (SAR) achievable at 1.5 T for brain magnetic resonance (MR) imaging without loss of tissue signal or contrast present in ...

    • Brain MRI Lesion Load at 1.5T and 3T versus Clinical Status in Multiple Sclerosis 

      Stankiewicz, James; Glanz, Bonnie; Healy, Brian Curran; Arora, Ashish; Neema, Mohit; Benedict, Ralph H.B.; Guss, Zachary D.; Tauhid, Shahamat Syed; Buckle, Guy J.; Houtchens, Maria K.; Khoury, Samia Joseph; Weiner, Howard Lee; Guttmann, Charles R.G.; Bakshi, Rohit (Wiley-Blackwell, 2011)
      Background/Purpose: To assess correlation between brain lesions and clinical status with 1.5T and 3T magnetic resonance imaging (MRI). Methods: Brain MRI fluid-attenuated inversion-recovery (FLAIR) sequences were performed ...

    • Brain MRI lesions and atrophy are associated with employment status in patients with multiple sclerosis 

      Tauhid, Shahamat; Chu, Renxin; Sasane, Rahul; Glanz, Bonnie I.; Neema, Mohit; Miller, Jennifer R.; Kim, Gloria; Signorovitch, James E.; Healy, Brian C.; Chitnis, Tanuja; Weiner, Howard L.; Bakshi, Rohit (Springer Berlin Heidelberg, 2015)
      Multiple sclerosis (MS) commonly affects occupational function. We investigated the link between brain MRI and employment status. Patients with MS (n = 100) completed a Work Productivity and Activity Impairment (WPAI) ...

    • Brain Networks of Novelty-Driven Involuntary and Cued Voluntary Auditory Attention Shifting 

      Huang, Samantha; Belliveau, John William; Tengshe, Chinmayi; Ahveninen, Jyrki Pekka (Public Library of Science, 2012)
      In everyday life, we need a capacity to flexibly shift attention between alternative sound sources. However, relatively little work has been done to elucidate the mechanisms of attention shifting in the auditory domain. ...

    • Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices 

      Ortiz-Terán, Laura; Ortiz, Tomás; Perez, David L.; Aragón, Jose Ignacio; Diez, Ibai; Pascual-Leone, Alvaro; Sepulcre, Jorge (Frontiers Media S.A., 2016)
      It is well established that the human brain reorganizes following sensory deprivations. In blind individuals, visual processing regions including the lateral occipital cortex (LOC) are activated by auditory and tactile ...

    • Brain Science: From the Very Small to the Very Large 

      Kreiman, Gabriel (Elsevier BV, 2007)

    • Brain temperature and its fundamental properties: a review for clinical neuroscientists 

      Wang, Huan; Wang, Bonnie; Normoyle, Kieran P.; Jackson, Kevin; Spitler, Kevin; Sharrock, Matthew F.; Miller, Claire M.; Best, Catherine; Llano, Daniel; Du, Rose (Frontiers Media S.A., 2014)
      Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although ...

    • Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression 

      Sullivan, James P; Nahed, Brian Vala; Madden, M. W.; Oliveira, S. M.; Springer, S.; Bhere, Deepak; Chi, A. S.; Wakimoto, Hiroaki; Rothenberg, S. M.; Sequist, Lecia VanDam; Kapur, R.; Shah, Khalid A.; Iafrate, Anthony John; Curry, William Thomas; Loeffler, Jay Steven; Batchelor, Tracy Todd; Louis, David N.; Toner, Mehmet; Maheswaran, Shyamala; Haber, Daniel Arie (American Association for Cancer Research (AACR), 2014)
      Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a microfluidic device to deplete hematopoietic ...

    • Brain Weight Differences Associated with Induced Focal Microgyria 

      Peiffer, Ann M; Fitch, R Holly; Thomas, Jennifer Joanne; Yurkovic, Alexandra Nicole; Rosen, Glenn David (BioMed Central, 2003)
      Background: Disrupting neural migration with bilateral focal freezing necrosis on postnatal day 1 (P1) results in the formation of 4-layered microgyria. This developmental injury triggers a pervasive neural reorganization, ...

    • Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder 

      Rosso, Isabelle M; Olson, Elizabeth A; Britton, Jennifer C; Stewart, S Evelyn; Papadimitriou, George; Killgore, William DS; Makris, Nikos; Wilhelm, Sabine; Jenike, Michael A; Rauch, Scott L (BioMed Central, 2014)
      Background: Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At ...

    • Brain white matter microstructure is associated with susceptibility to motion-induced nausea 

      Napadow, Vitaly J.; Sheehan, J.; Kim, Jieun; Dassatti, Allison; Thurler, Andrea H.; Surjanhata, Brian; Vangel, Mark G.; Makris, Nikolaos; Schaechter, Judith Diane; Kuo, Braden (Wiley, 2013)
      Nausea is associated with significant morbidity, and there is a wide range in the propensity of individuals to experience nausea. The neural basis of this heterogeneity in nausea susceptibility is poorly understood. Our ...

    • Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study 

      Fang, Jiliang; Wang, Danhong; Zhao, Qing; Hong, Yang; Jin, Yulian; Liu, Zhishun; Zhou, Kehua; Jing, Xianghong; Yu, Xiaochun; Pan, Ruiqi; Chang, Andrew; Liu, Hesheng; Zhu, Bing (Hindawi Publishing Corporation, 2015)
      Objective:. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD). Methods:. Eight patients in an acupuncture treatment group and ten healthy adults in the control group ...

    • Brainhack: a collaborative workshop for the open neuroscience community 

      Cameron Craddock, R.; S. Margulies, Daniel; Bellec, Pierre; Nolan Nichols, B.; Alcauter, Sarael; A. Barrios, Fernando; Burnod, Yves; J. Cannistraci, Christopher; Cohen-Adad, Julien; De Leener, Benjamin; Dery, Sebastien; Downar, Jonathan; Dunlop, Katharine; R. Franco, Alexandre; Seligman Froehlich, Caroline; J. Gerber, Andrew; S. Ghosh, Satrajit; J. Grabowski, Thomas; Hill, Sean; Sólon Heinsfeld, Anibal; Matthew Hutchison, R.; Kundu, Prantik; R. Laird, Angela; Liew, Sook-Lei; J. Lurie, Daniel; G. McLaren, Donald; Meneguzzi, Felipe; Mennes, Maarten; Mesmoudi, Salma; O’Connor, David; H. Pasaye, Erick; Peltier, Scott; Poline, Jean-Baptiste; Prasad, Gautam; Fraga Pereira, Ramon; Quirion, Pierre-Olivier; Rokem, Ariel; S. Saad, Ziad; Shi, Yonggang; C. Strother, Stephen; Toro, Roberto; Q. Uddin, Lucina; D. Van Horn, John; W. Van Meter, John; C. Welsh, Robert; Xu, Ting (BioMed Central, 2016)
      Brainhack events offer a novel workshop format with participant-generated content that caters to the rapidly growing open neuroscience community. Including components from hackathons and unconferences, as well as parallel ...

    • A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance 

      Jang, Cholsoon; Oh, Sungwhan F; Wada, Shogo; Rowe, Glenn C; Liu, Laura; Chan, Mun Chun; Rhee, James; Hoshino, Atsushi; Kim, Boa; Ibrahim, Ayon; Baca, Luisa G; Kim, Esl; Ghosh, Chandra C; Parikh, Samir M; Jiang, Aihua; Chu, Qingwei; Forman, Daniel E.; Lecker, Stewart H.; Krishnaiah, Saikumari; Rabinowitz, Joshua D; Weljie, Aalim M; Baur, Joseph A; Kasper, Dennis L; Arany, Zoltan (2016)
      Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.1–3 Insulin resistance in skeletal muscle ...

    • BRCA1 and CtIP suppress long tract gene conversion between sister chromatids 

      Chandramouly, Gurushankar; Kwok, Amy; Huang, Bin; Willis, Nicholas A.; Xie, Anyong; Scully, Ralph (2013)
      BRCA1 controls early steps of the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination, but has no known role following Rad51-mediated synapsis. Here we show that BRCA1 influences post-synaptic ...

    • BRCA1 as tumor suppressor: lord without its RING? 

      Elia, Andrew Eugene; Elledge, Stephen J. (BioMed Central, 2012)
      BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of ...

    • BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks 

      Willis, Nicholas A.; Chandramouly, Gurushankar; Huang, Bin; Kwok, Amy; Follonier, Cindy; Deng, Chuxia; Scully, Ralph (2014)
      Replication fork stalling can promote genomic instability, predisposing to cancer and other diseases1–3. Stalled replication forks may be processed by sister chromatid recombination (SCR), generating error-free or error-prone ...

    • A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity 

      McMullin, Ryan P; Wittner, Ben S; Yang, Chuanwei; Denton-Schneider, Benjamin R; Hicks, Daniel; Singavarapu, Raj; Moulis, Sharon; Lee, Jeongeun; Akbari, Mohammad R; Narod, Steven A; Aldape, Kenneth D; Steeg, Patricia S; Ramaswamy, Sridhar; Sgroi, Dennis C (BioMed Central, 2014)
      Introduction: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways ...