Browsing HMS Scholarly Articles by Title
Now showing items 1877-1896 of 17917
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Brain Plasticity in Blind Subjects Centralizes Beyond the Modal Cortices
(Frontiers Media S.A., 2016)It is well established that the human brain reorganizes following sensory deprivations. In blind individuals, visual processing regions including the lateral occipital cortex (LOC) are activated by auditory and tactile ... -
Brain Science: From the Very Small to the Very Large
(Elsevier BV, 2007) -
Brain temperature and its fundamental properties: a review for clinical neuroscientists
(Frontiers Media S.A., 2014)Brain temperature, as an independent therapeutic target variable, has received increasingly intense clinical attention. To date, brain hypothermia represents the most potent neuroprotectant in laboratory studies. Although ... -
Brain Tumor Cells in Circulation Are Enriched for Mesenchymal Gene Expression
(American Association for Cancer Research (AACR), 2014)Glioblastoma (GBM) is a highly aggressive brain cancer characterized by local invasion and angiogenic recruitment, yet metastatic dissemination is extremely rare. Here, we adapted a microfluidic device to deplete hematopoietic ... -
Brain Weight Differences Associated with Induced Focal Microgyria
(BioMed Central, 2003)Background: Disrupting neural migration with bilateral focal freezing necrosis on postnatal day 1 (P1) results in the formation of 4-layered microgyria. This developmental injury triggers a pervasive neural reorganization, ... -
Brain white matter integrity and association with age at onset in pediatric obsessive-compulsive disorder
(BioMed Central, 2014)Background: Obsessive-compulsive disorder (OCD) is a common and debilitating neuropsychiatric illness thought to involve abnormal connectivity of widespread brain networks, including frontal-striatal-thalamic circuits. At ... -
Brain white matter microstructure is associated with susceptibility to motion-induced nausea
(Wiley, 2013)Nausea is associated with significant morbidity, and there is a wide range in the propensity of individuals to experience nausea. The neural basis of this heterogeneity in nausea susceptibility is poorly understood. Our ... -
Brain-Gut Axis Modulation of Acupuncture in Functional Dyspepsia: A Preliminary Resting-State fcMRI Study
(Hindawi Publishing Corporation, 2015)Objective:. To explore acupuncture effects on brain functional connectivity in patients with functional dyspepsia (FD). Methods:. Eight patients in an acupuncture treatment group and ten healthy adults in the control group ... -
Brainhack: a collaborative workshop for the open neuroscience community
(BioMed Central, 2016)Brainhack events offer a novel workshop format with participant-generated content that caters to the rapidly growing open neuroscience community. Including components from hackathons and unconferences, as well as parallel ... -
A branched chain amino acid metabolite drives vascular transport of fat and causes insulin resistance
(2016)Epidemiological and experimental data implicate branched chain amino acids (BCAAs) in the development of insulin resistance, but the mechanisms underlying this link remain unclear.1–3 Insulin resistance in skeletal muscle ... -
BRCA1 and CtIP suppress long tract gene conversion between sister chromatids
(2013)BRCA1 controls early steps of the synthesis-dependent strand annealing (SDSA) pathway of homologous recombination, but has no known role following Rad51-mediated synapsis. Here we show that BRCA1 influences post-synaptic ... -
BRCA1 as tumor suppressor: lord without its RING?
(BioMed Central, 2012)BRCA1 is a tumor suppressor with critical roles in the maintenance of genomic stability. It encodes a large protein with an amino-terminal RING domain that possesses ubiquitin-ligase activity. Given the occurrence of ... -
BRCA1 controls homologous recombination at Tus/Ter-stalled mammalian replication forks
(2014)Replication fork stalling can promote genomic instability, predisposing to cancer and other diseases1–3. Stalled replication forks may be processed by sister chromatid recombination (SCR), generating error-free or error-prone ... -
A BRCA1 deficient-like signature is enriched in breast cancer brain metastases and predicts DNA damage-induced poly (ADP-ribose) polymerase inhibitor sensitivity
(BioMed Central, 2014)Introduction: There is an unmet clinical need for biomarkers to identify breast cancer patients at an increased risk of developing brain metastases. The objective is to identify gene signatures and biological pathways ... -
BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis
(The Rockefeller University Press, 2014)During meiosis, DNA damage response (DDR) proteins induce transcriptional silencing of unsynapsed chromatin, including the constitutively unsynapsed XY chromosomes in males. DDR proteins are also implicated in double strand ... -
BRCA1 haploinsufficiency for replication stress suppression in primary cells
(Nature Pub. Group, 2014)BRCA1—a breast and ovarian cancer suppressor gene—promotes genome integrity. To study the functionality of BRCA1 in the heterozygous state, we established a collection of primary human BRCA1+/+ and BRCA1mut/+ mammary ... -
BRCA1 Recruitment to Transcriptional Pause Sites Is Required for R-Loop-Driven DNA Damage Repair
(Cell Press, 2015)Summary The mechanisms contributing to transcription-associated genomic instability are both complex and incompletely understood. Although R-loops are normal transcriptional intermediates, they are also associated with ... -
BRCAPRO Validation, Sensitivity of Genetic Testing ofBRCA1/BRCA2, and Prevalence of Other Breast Cancer Susceptibility Genes
(American Society of Clinical Oncology (ASCO), 2002) -
Break to Make a Connection
(Public Library of Science (PLoS), 2011-02-24) -
Breaking the News or Fueling the Epidemic? Temporal Association between News Media Report Volume and Opioid-Related Mortality
(Public Library of Science, 2009)Background: Historical studies of news media have suggested an association between reporting and increased drug abuse. Period effects for substance use have been documented for different classes of legal and illicit ...