Browsing HMS Scholarly Articles by Title

Now showing items 1940-1959 of 17922

    • Broadly permissive intestinal chromatin underlies lateral inhibition and cell plasticity 

      Kim, Tae-Hee; Li, Fugen; Ferreiro-Neira, Isabel; Ho, Li-Lun; Luyten, Annouck; Nalapareddy, Kodandaramireddy; Long, Henry; Verzi, Michael; Shivdasani, Ramesh A. (2014)
      Cells differentiate when transcription factors (TFs) bind accessible cis-regulatory elements to establish specific gene expression programs. In differentiating embryonic stem (ES) cells, chromatin at lineage-restricted ...

    • Brown adipose tissue 

      Townsend, Kristy L; Tseng, Yu-Hua (Landes Bioscience, 2012)
      Obesity is currently a global pandemic, and is associated with increased mortality and co-morbidities including many metabolic diseases. Obesity is characterized by an increase in adipose mass due to increased energy intake, ...

    • Brown Adipose Tissue Activation Is Inversely Related to Central Obesity and Metabolic Parameters in Adult Human 

      Wang, Qidi; Zhang, Min; Xu, Min; Gu, Weiqiong; Xi, Yun; Qi, Lu; Li, Biao; Wang, Weiqing (Public Library of Science, 2015)
      Background: Recent studies have shown that adult human possess active brown adipose tissue (BAT), which might be important in affecting obesity. However, the supporting evidence on the relationship between BAT and central ...

    • Brown Adipose Tissue Blood Flow and Mass in Obesity: A Contrast Ultrasound Study in Mice 

      Clerte, Maëva; Baron, David William; Brouckaert, Peter; Ernande, Laura; Raher, Michael J.; Flynn, Aidan W.; Picard, Michael Howard; Bloch, Kenneth; Buys, Emmanuel; Scherrer-Crosbie, Marielle (Elsevier BV, 2013)
      Background: When activated by the sympathetic nervous system, brown adipose tissue (BAT) increases energy expenditure to produce heat. Augmenting BAT mass or increasing BAT activation could potentially be used to decrease ...

    • Brown Fat and Browning for the Treatment of Obesity and Related Metabolic Disorders 

      Kim, So Hun; Plutzky, Jorge (Korean Diabetes Association, 2016)
      Brown fat is a specialized fat depot that can increase energy expenditure and produce heat. After the recent discovery of the presence of active brown fat in human adults and novel transcription factors controlling brown ...

    • Brown Fat Paucity Due to Impaired BMP Signaling Induces Compensatory Browning of White Fat 

      Schulz, Tim J.; Huang, Ping; Huang, Tian Lian; Xue, Ruidan; McDougall, Lindsay E.; Townsend, Kristy L.; Cypess, Aaron M.; Mishina, Yuji; Gussoni, Emanuela; Tseng, Yu-Hua (2013)
      Summary Maintenance of body temperature is essential for survival of homeotherms. Brown adipose tissue (BAT) is a specialized fat tissue that is dedicated to thermoregulation1. Due to its remarkable capacity to dissipate ...

    • A Brush with Danger 

      Hirsch, Alexander; Popovsky, Erica; Nigrovic, Lise; Burns, Michele (Western Journal of Emergency Medicine, 2018-09-05)
      A five-year-old male presented to the emergency department (ED) after falling off a stool while brushing his teeth, resulting in a penetrating oropharyngeal injury. The toothbrush was impaled deeply into the left lateral ...

    • BTLA expression declines on B cells of the aged and is associated with low responsiveness to the trivalent influenza vaccine 

      Kannan, Senthil; Kurupati, Raj K.; Doyle, Susan A.; Freeman, Gordon J.; Schmader, Kenneth E.; Ertl, Hildegund C.J. (Impact Journals LLC, 2015)
      Virus-neutralizing antibody and B cell responses to influenza A viruses were measured in 35 aged and 28 middle-aged individuals following vaccination with the 2012 and 2013 trivalent inactivated influenza vaccines. Antibody ...

    • Bubble CPAP to support preterm infants in rural Rwanda: a retrospective cohort study 

      Nahimana, Evrard; Ngendahayo, Masudi; Magge, Hema; Odhiambo, Jackline; Amoroso, Cheryl L.; Muhirwa, Ernest; Uwilingiyemungu, Jean Nepo; Nkikabahizi, Fulgence; Habimana, Regis; Hedt-Gauthier, Bethany L. (BioMed Central, 2015)
      Background: Complications from premature birth contribute to 35 % of neonatal deaths globally; therefore, efforts to improve clinical outcomes of preterm (PT) infants are imperative. Bubble continuous positive airway ...

    • Building Blocks for the Construction of Bioorthogonally Reactive Peptides via Solid-Phase Peptide Synthesis 

      Zeglis, Brian M; Emmetiere, Fabien; Pillarsetty, Nagavarakishore; Weissleder, Ralph; Lewis, Jason S; Reiner, Thomas (Wiley-VCH Verlag GmbH & Co, 2014)
      The need for post-synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents. In this regard, the application of biologically ...

    • The building blocks of social communication 

      Niznikiewicz, Margaret A. (University of Finance and Management in Warsaw, 2013)
      In the present review, social communication will be discussed in the context of social cognition, and cold and hot cognition. The review presents research on prosody, processing of faces, multimodal processing of voice and ...

    • Building from the HIV Response toward Universal Health Coverage 

      Jay, Jonathan; Buse, Kent; Hart, Marielle; Wilson, David; Marten, Robert; Kellerman, Scott; Odetoyinbo, Morolake; Quick, Jonathan D.; Evans, Timothy; Piot, Peter; Dybul, Mark; Binagwaho, Agnes (Public Library of Science, 2016)
      Jonathan Jay and colleagues draw lessons from the the global HIV response that could help guide the universal health coverage movement.

    • Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities 

      Polka, Jessica; Hays, Stephanie Grace; Silver, Pamela A. (Cold Spring Harbor Laboratory Press, 2016)
      Traditional views of synthetic biology often treat the cell as an unstructured container in which biological reactions proceed uniformly. In reality, the organization of biological molecules has profound effects on cellular ...

    • Bulk effect of the deltoid muscle on the glenohumeral joint 

      Rosso, Claudio; Mueller, Andreas M; McKenzie, Brett; Entezari, Vahid; Cereatti, Andrea; Croce, Ugo Della; Ramappa, Arun J; Nazarian, Ara; DeAngelis, Joseph P (Springer Berlin Heidelberg, 2014)
      Background: There remains controversy on the role of the deltoid on glenohumeral translations during basic and pitching motions. We thus studied the passive effect of the deltoid on the deltoid glenohumeral joint center ...

    • Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures 

      Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)
      Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ...

    • Bunched, the Drosophila Homolog of the Mammalian Tumor Suppressor TSC-22, Promotes Cellular Growth 

      Gluderer, Silvia; Oldham, Sean; Rintelen, Felix; Sulzer, Andrea; Schütt, Corina; Wu, Xiaodong; Raftery, Laurel Anne; Hafen, Ernst; Stocker, Hugo (BioMed Central, 2008)
      Background: Transforming Growth Factor-β1 stimulated clone-22 (TSC-22) is assumed to act as a negative growth regulator and tumor suppressor. TSC-22 belongs to a family of putative transcription factors encoded by four ...

    • Bupropion Reduces Some of the Symptoms of Marihuana Withdrawal in Chronic Marihuana Users: A Pilot Study 

      Penetar, David Michael; Looby, Alison R.; Ryan, Elizabeth T.; Maywalt, Melissa A.; Lukas, Scott E. (Libertas Academica, 2012)
      Bupropion’s (Zyban® SR) effectiveness to treat symptoms experienced in marihuana withdrawal was tested in a double-blind, placebo-controlled study with chronic, heavy marihuana users. Participants maintained their usual ...

    • Burden and predictors of hypertension in India: results of SEEK (Screening and Early Evaluation of Kidney Disease) study 

      Farag, Youssef MK; Mittal, Bharati V; Keithi-Reddy, Sai Ram; Acharya, Vidya N; Almeida, Alan F; C, Anil; HS, Ballal; P, Gaccione; R, Issacs; Jasuja, Sanjiv; AL, Kirpalani; V, Kher; GK, Modi; Nainan, Georgy; Prakash, Jai; Rajapurkar, Mohan M; DS, Rana; Sreedhara, Rajanna; DK, Sinha; Shah, Bharat V; Sunder, Sham; Sharma, Raj Kumar; Seetharam, Sridevi; Raju, Tatapudi Ravi; Singh, Ajay K (BioMed Central, 2014)
      Background: Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. Methods: 6120 subjects participated ...

    • Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity 

      Molenaar, Esther A.; Hwang, Shih-Jen; Vasan, Ramachandran S.; Grobbee, Diederick E.; Meigs, James Benjamin; D'Agostino, Ralph B.; Levy, Daniel; Fox, Caroline (American Diabetes Association, 2008)
      OBJECTIVE—Obesity is associated with an increased risk for cardiovascular disease (CVD). We sought to determine rates of treatment and control of CVD risk factors among normal weight, overweight, and obese individuals in ...

    • Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction 

      Kesselheim, Aaron Seth; Bykov, Katsiaryna; Avorn, Jerry Lewis; Tong, Angela; Doherty, Michael Joseph; Choudhry, Niteesh Kumar (American College of Physicians, 2014)
      Background: Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these drug products may interrupt medication use. Objective: To determine whether nonpersistent use of ...