Browsing HMS Scholarly Articles by Title

Now showing items 1951-1970 of 17922

    • Building from the HIV Response toward Universal Health Coverage 

      Jay, Jonathan; Buse, Kent; Hart, Marielle; Wilson, David; Marten, Robert; Kellerman, Scott; Odetoyinbo, Morolake; Quick, Jonathan D.; Evans, Timothy; Piot, Peter; Dybul, Mark; Binagwaho, Agnes (Public Library of Science, 2016)
      Jonathan Jay and colleagues draw lessons from the the global HIV response that could help guide the universal health coverage movement.

    • Building Spatial Synthetic Biology with Compartments, Scaffolds, and Communities 

      Polka, Jessica; Hays, Stephanie Grace; Silver, Pamela A. (Cold Spring Harbor Laboratory Press, 2016)
      Traditional views of synthetic biology often treat the cell as an unstructured container in which biological reactions proceed uniformly. In reality, the organization of biological molecules has profound effects on cellular ...

    • Bulk effect of the deltoid muscle on the glenohumeral joint 

      Rosso, Claudio; Mueller, Andreas M; McKenzie, Brett; Entezari, Vahid; Cereatti, Andrea; Croce, Ugo Della; Ramappa, Arun J; Nazarian, Ara; DeAngelis, Joseph P (Springer Berlin Heidelberg, 2014)
      Background: There remains controversy on the role of the deltoid on glenohumeral translations during basic and pitching motions. We thus studied the passive effect of the deltoid on the deltoid glenohumeral joint center ...

    • Bumetanide Enhances Phenobarbital Efficacy in a Rat Model of Hypoxic Neonatal Seizures 

      Cleary, Ryan T.; Sun, Hongyun; Huynh, Thanhthao; Manning, Simon; Li, Yijun; Rotenberg, Alexander; Talos, Delia M.; Kahle, Kristopher Thomas; Jackson, Michele; Rakhade, Sanjay N.; Berry, Gerard T.; Jensen, Frances Elizabeth (Public Library of Science, 2013)
      Neonatal seizures can be refractory to conventional anticonvulsants, and this may in part be due to a developmental increase in expression of the neuronal Na+-K+-2 Cl− cotransporter, NKCC1, and consequent paradoxical ...

    • Bunched, the Drosophila Homolog of the Mammalian Tumor Suppressor TSC-22, Promotes Cellular Growth 

      Gluderer, Silvia; Oldham, Sean; Rintelen, Felix; Sulzer, Andrea; Schütt, Corina; Wu, Xiaodong; Raftery, Laurel Anne; Hafen, Ernst; Stocker, Hugo (BioMed Central, 2008)
      Background: Transforming Growth Factor-β1 stimulated clone-22 (TSC-22) is assumed to act as a negative growth regulator and tumor suppressor. TSC-22 belongs to a family of putative transcription factors encoded by four ...

    • Bupropion Reduces Some of the Symptoms of Marihuana Withdrawal in Chronic Marihuana Users: A Pilot Study 

      Penetar, David Michael; Looby, Alison R.; Ryan, Elizabeth T.; Maywalt, Melissa A.; Lukas, Scott E. (Libertas Academica, 2012)
      Bupropion’s (Zyban® SR) effectiveness to treat symptoms experienced in marihuana withdrawal was tested in a double-blind, placebo-controlled study with chronic, heavy marihuana users. Participants maintained their usual ...

    • Burden and predictors of hypertension in India: results of SEEK (Screening and Early Evaluation of Kidney Disease) study 

      Farag, Youssef MK; Mittal, Bharati V; Keithi-Reddy, Sai Ram; Acharya, Vidya N; Almeida, Alan F; C, Anil; HS, Ballal; P, Gaccione; R, Issacs; Jasuja, Sanjiv; AL, Kirpalani; V, Kher; GK, Modi; Nainan, Georgy; Prakash, Jai; Rajapurkar, Mohan M; DS, Rana; Sreedhara, Rajanna; DK, Sinha; Shah, Bharat V; Sunder, Sham; Sharma, Raj Kumar; Seetharam, Sridevi; Raju, Tatapudi Ravi; Singh, Ajay K (BioMed Central, 2014)
      Background: Hypertension (HTN) is one of the major causes of cardiovascular morbidity and mortality. The objective of the study was to investigate the burden and predictors of HTN in India. Methods: 6120 subjects participated ...

    • Burden and Rates of Treatment and Control of Cardiovascular Disease Risk Factors in Obesity 

      Molenaar, Esther A.; Hwang, Shih-Jen; Vasan, Ramachandran S.; Grobbee, Diederick E.; Meigs, James Benjamin; D'Agostino, Ralph B.; Levy, Daniel; Fox, Caroline (American Diabetes Association, 2008)
      OBJECTIVE—Obesity is associated with an increased risk for cardiovascular disease (CVD). We sought to determine rates of treatment and control of CVD risk factors among normal weight, overweight, and obese individuals in ...

    • Burden of Changes in Pill Appearance for Patients Receiving Generic Cardiovascular Medications After Myocardial Infarction 

      Kesselheim, Aaron Seth; Bykov, Katsiaryna; Avorn, Jerry Lewis; Tong, Angela; Doherty, Michael Joseph; Choudhry, Niteesh Kumar (American College of Physicians, 2014)
      Background: Generic prescription drugs made by different manufacturers may vary in color or shape, and switching among these drug products may interrupt medication use. Objective: To determine whether nonpersistent use of ...

    • The burden of clostridium difficile infection: estimates of the incidence of CDI from U.S. Administrative databases 

      Olsen, Margaret A.; Young-Xu, Yinong; Stwalley, Dustin; Kelly, Ciarán P.; Gerding, Dale N.; Saeed, Mohammed J.; Mahé, Cedric; Dubberke, Erik R. (BioMed Central, 2016)
      Background: Many administrative data sources are available to study the epidemiology of infectious diseases, including Clostridium difficile infection (CDI), but few publications have compared CDI event rates across databases ...

    • The burden of hypertension in sub-Saharan Africa: a four-country cross sectional study 

      Guwatudde, David; Nankya-Mutyoba, Joan; Kalyesubula, Robert; Laurence, Carien; Adebamowo, Clement; Ajayi, IkeOluwapo; Bajunirwe, Francis; Njelekela, Marina; Chiwanga, Faraja S.; Reid, Todd; Volmink, Jimmy; Adami, Hans-Olov; Holmes, Michelle D.; Dalal, Shona (BioMed Central, 2015)
      Background: Hypertension, the leading single cause of morbidity and mortality worldwide, is a growing public health problem in sub-Saharan Africa (SSA). Few studies have estimated and compared the burden of hypertension ...

    • Burden of illness score for elderly persons (BISEP): Risk adjustment incorporating the cumulative impact of diseases, physiologic abnormalities and functional impairments. 

      Inouye, Sharon; Bogardus, Sidney T.; Vitagliano, Gail; Desai, Mayur; Williams, Christianna; Grady, Jacqueline; Scinto, Jeanne (Lippincott Williams & Wilkins, Inc., 2003)
      Background/Objectives. To develop and validate a new risk adjustment index-the Burden of Illness Score for Elderly Persons (BISEP)-which integrates multiple domains, including diseases, physiologic abnormalities, and ...

    • The Burden of Inflammatory Bowel Disease: A Patient-Reported Qualitative Analysis and Development of a Conceptual Model 

      Devlen, Jennifer; Beusterien, Kathleen; Yen, Linnette; Ahmed, Awais; Cheifetz, Adam S.; Moss, Alan C (Ovid Technologies (Wolters Kluwer Health), 2014)
      Background The aim of this study was to describe the impacts of inflammatory bowel disease (IBD) from the patients’ perspective, and to inform the development of a conceptual model. Methods Focus groups and ...

    • Buried Barrett's Epithelium Following Photodynamic Therapy Shows Reduced Crypt Proliferation and Absence of DNA Content Abnormalities 

      Hornick, Jason L.; Mino-Kenudson, Mari; Lauwers, Gregory Y.; Liu, Weitian; Goyal, Raj K.; Odze, Robert D. (Springer Nature, 2008)
      OBJECTIVES: Photodynamic therapy (PDT) is increasingly used for the treatment of patients with Barrett's esophagus (BE) with dysplasia or early carcinoma. Post-PDT, some patients show residual BE either exposed to the ...

    • Burkholderia spp. Alter Pseudomonas aeruginosa Physiology through Iron Sequestration 

      Weaver, Valerie B.; Kolter, Roberto (American Society for Microbiology, 2004)
      Pseudomonas aeruginosa and members of the Burkholderia cepacia complex often coexist in both the soil and the lungs of cystic fibrosis patients. To gain an understanding of how these different species affect each other's ...

    • Burn injury differentially alters whole-blood and organ glutathione synthesis rates: An experimental model 

      Fei, Zhe-Wei; Young, Vernon R.; Lu, Xiao-Ming; Rhodes, Andrew B.; Tompkins, Ronald G.; Fischman, Alan J.; Yu, Yong-Ming (BioMed Central, 2013)
      Previous studies from our laboratories revealed a reduced rate of whole-blood (WB) glutathione (GSH) synthesis in severely burned patients. To determine whether WB GSH metabolism is an indicator of the status of GSH ...

    • Burn Injury Reduces Neutrophil Directional Migration Speed in Microfluidic Devices 

      Butler, Kathryn Lee; Ambravaneswaran, Vijayakrishnan; Agrawal, Nitin; Bilodeau, Maryelizabeth; Toner, Mehmet; Tompkins, Ronald Gary; Fagan, Shawn P.; Irimia, Daniel (Public Library of Science, 2010)
      Thermal injury triggers a fulminant inflammatory cascade that heralds shock, end-organ failure, and ultimately sepsis and death. Emerging evidence points to a critical role for the innate immune system, and several studies ...

    • Burning Cold: Involvement of TRPA1 in Noxious Cold Sensation 

      Kwan, Kelvin Y; Corey, David Paul (The Rockefeller University Press, 2009)
      Soon after its discovery ten years ago, the ion channel TRPA1 was proposed as a sensor of noxious cold. Evidence for its activation by painfully cold temperatures (below ~15° C) has been mixed, however. Some groups found ...

    • The business of genomic testing: a survey of early adopters 

      Crawford, James M.; Bry, Lynn; Pfeifer, John; Caughron, Samuel K.; Black-Schaffer, Stephen; Kant, Jeffrey A.; Kaufman, Jill H. (Nature Publishing Group, 2014)
      Purpose: The practice of “genomic” (or “personalized”) medicine requires the availability of appropriate diagnostic testing. Our study objective was to identify the reasons for health systems to bring next-generation ...

    • Button-pressing affects P300 amplitude and scalp topography 

      Salisbury, Dean F; Rutherford, Bret; Shenton, Martha Elizabeth; McCarley, Robert William (Elsevier BV, 2001)
      Background: Scant and equivocal research exists examining the effects of button-pressing on P300. Button-pressing may decrease P300 latency and amplitude. The melding of motor potentials and P300 may also confound studies ...