Browsing HMS Scholarly Articles by Title

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    • The cavefish genome reveals candidate genes for eye loss 

      McGaugh, Suzanne E.; Gross, Joshua B.; Aken, Bronwen; Blin, Maryline; Borowsky, Richard; Chalopin, Domitille; Hinaux, Hélène; Jeffery, William R.; Keene, Alex; Ma, Li; Minx, Patrick; Murphy, Daniel; O’Quin, Kelly E.; Rétaux, Sylvie; Rohner, Nicolas; Searle, Steve M. J.; Stahl, Bethany A.; Tabin, Cliff; Volff, Jean-Nicolas; Yoshizawa, Masato; Warren, Wesley C. (Nature Pub. Group, 2014)
      Natural populations subjected to strong environmental selection pressures offer a window into the genetic underpinnings of evolutionary change. Cavefish populations, Astyanax mexicanus (Teleostei: Characiphysi), exhibit ...

    • Caveolin 1 Modulates Aldosterone‐Mediated Pathways of Glucose and Lipid Homeostasis 

      Baudrand, Rene; Gupta, Nidhi; Garza, Amanda E.; Vaidya, Anand; Leopold, Jane A.; Hopkins, Paul N.; Jeunemaitre, Xavier; Ferri, Claudio; Romero, Jose R.; Williams, Jonathan; Loscalzo, Joseph; Adler, Gail K.; Williams, Gordon H.; Pojoga, Luminita H. (John Wiley and Sons Inc., 2016)
      Background: Overactivation of the aldosterone and mineralocorticoid receptor (MR) pathway is associated with hyperglycemia and dyslipidemia. Caveolin 1 (cav‐1) is involved in glucose/lipid homeostasis and may modulate MR ...

    • Caveolin-1 Associated Adenovirus Entry into Human Corneal Cells 

      Yousuf, Mohammad A.; Zhou, Xiaohong; Mukherjee, Santanu; Chintakuntlawar, Ashish V.; Lee, Jeong Yoon; Ramke, Mirja; Chodosh, James; Rajaiya, Jaya (Public Library of Science, 2013)
      The cellular entry of viruses represents a critical area of study, not only for viral tropism, but also because viral entry dictates the nature of the immune response elicited upon infection. Epidemic keratoconjunctivitis ...

    • Caveolin-1 Inhibits Expression of Antioxidant Enzymes through Direct Interaction with Nuclear Erythroid 2 p45-related Factor-2 (Nrf2) 

      Li, W.; Liu, H.; Zhou, J.-S.; Cao, J.-F.; Zhou, Xiaobo; Choi, A. M. K.; Chen, Z.-H.; Shen, H.-H. (American Society for Biochemistry & Molecular Biology (ASBMB), 2012)
      The Nrf2 (nuclear erythroid 2 p45-related factor-2) signaling pathway is known to play a pivotal role in a variety of oxidative stress-related human disorders. It has been reported recently that the plasma membrane resident ...

    • Caveolin-1 Is a Critical Determinant of Autophagy, Metabolic Switching, and Oxidative Stress in Vascular Endothelium 

      Shiroto, Takashi; Romero, Natalia; Sugiyama, Toru; Sartoretto, Juliano L.; Kalwa, Hermann; Yan, Zhonghua; Shimokawa, Hiroaki; Michel, Thomas (Public Library of Science, 2014)
      Caveolin-1 is a scaffolding/regulatory protein that interacts with diverse signaling molecules. Caveolin-1null mice have marked metabolic abnormalities, yet the underlying molecular mechanisms are incompletely understood. ...

    • Cavum septi pellucidi in first-episode schizophrenia and first-episode affective psychosis: an MRI study 

      Kasai, Kiyoto; McCarley, Robert William; Salisbury, Dean F.; Onitsuka, Toshiaki; Demeo, Susan; Yurgelun-Todd, Deborah; Kikinis, Ron; Jolesz, Ferenc A.; Shenton, Martha Elizabeth (Elsevier BV, 2004)
      A high prevalence of abnormal cavum septi pellucidi (CSP) in schizophrenia may reflect neurodevelopmental abnormalities in midline structures of the brain. The relationship, however, between abnormal CSP and clinical ...

    • Cavum septum pellucidum in monozygotic twins discordant for combat exposure: relationship to posttraumatic stress disorder 

      May, Flavia S; Chen, Q.Cece; Gilbertson, Mark; Shenton, Martha Elizabeth; Pitman, roger Keith (Elsevier BV, 2004)
      Background Abnormally large cavum septum pellucidum has been reported in posttraumatic stress disorder; however, the origin of this association is uncertain. Methods: We utilized magnetic resonance imaging to measure ...

    • CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases 

      Tan, Yi-Hung Carol; Krishnaswamy, Soundararajan; Nandi, Suvobroto; Kanteti, Rajani; Vora, Sapana; Onel, Kenan; Hasina, Rifat; Lo, Fang-Yi; El-Hashani, Essam; Cervantes, Gustavo; Lipkowitz, Stanley; Karrison, Theodore; Vokes, Everett E.; Wang, Yi-Ching; Salgia, Ravi; Najbauer, Joseph; Robinson, Matthew; Kales, Stephen C.; Sattler, Martin (Public Library of Science, 2010)
      Background: Non-small cell lung cancer (NSCLC) is a heterogeneous group of disorders with a number of genetic and proteomic alterations. c-CBL is an E3 ubiquitin ligase and adaptor molecule important in normal homeostasis ...

    • CC2D1A Regulates Human Intellectual and Social Function as well as NF-κB Signaling Homeostasis 

      Manzini, M. Chiara; Xiong, Lan; Shaheen, Ranad; Tambunan, Dimira E.; Di Costanzo, Stefania; Mitisalis, Vanessa; Tischfield, David J.; Cinquino, Antonella; Ghaziuddin, Mohammed; Christian, Mehtab; Jiang, Qin; Laurent, Sandra; Nanjiani, Zohair A.; Rasheed, Saima; Hill, R. Sean; Lizarraga, Sofia B.; Gleason, Danielle; Sabbagh, Diya; Salih, Mustafa A.; Alkuraya, Fowzan S.; Walsh, Christopher A. (2015)
      SUMMARY Autism spectrum disorder (ASD) and intellectual disability (ID) are often comorbid, but the extent to which they share common genetic causes remains controversial. Here, we present two autosomal-recessive “founder” ...

    • CCAAT/Enhancer Binding Protein β Is Dispensable for Development of Lung Adenocarcinoma 

      Cai, Yi; Hirata, Ayako; Nakayama, Sohei; VanderLaan, Paul A.; Levantini, Elena; Yamamoto, Mihoko; Hirai, Hideyo; Wong, Kwok-Kin; Costa, Daniel B.; Watanabe, Hideo; Kobayashi, Susumu S. (Public Library of Science, 2015)
      Lung cancer is the leading cause of cancer death worldwide. Although disruption of normal proliferation and differentiation is a vital component of tumorigenesis, the mechanisms of this process in lung cancer are still ...

    • CCAAT/Enhancer-Binding Protein \(\gamma\) Is a Critical Regulator of IL-1\(\beta\)-Induced IL-6 Production in Alveolar Epithelial Cells 

      Yan, Chunguang; Wang, Ximo; Cao, Jay; Wu, Min; Gao, Hongwei (Public Library of Science, 2012)
      CCAAT/enhancer binding protein \(\gamma\) (C/EBPγ) is a member of the C/EBP family of transcription factors, which lacks known activation domains. C/EBP\(\gamma\) was originally described as an inhibitor of C/EBP transactivation ...

    • CCAAT/Enhancer-Binding Protein Homologous (CHOP) Protein Promotes Carcinogenesis in the DEN-Induced Hepatocellular Carcinoma Model 

      Scaiewicz, Viviana; Nahmias, Avital; Chung, Raymond T.; Mueller, Tobias; Tirosh, Boaz; Shibolet, Oren (Public Library of Science, 2013)
      Background and Aims C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism. ...

    • Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53 

      Sorrells, Shelly; Carbonneau, Seth; Harrington, Erik; Chen, Aye T.; Hast, Bridgid; Milash, Brett; Major, Michael B.; Stewart, Rodney A.; Jette, Cicely; Pyati, Ujwal Jagdeesh; Zon, Leonard Ira; Look, A. Thomas; Zhou, Yi (Public Library of Science, 2012)
      DNA double-strand breaks (DSBs) represent one of the most deleterious forms of DNA damage to a cell. In cancer therapy, induction of cell death by DNA DSBs by ionizing radiation (IR) and certain chemotherapies is thought ...

    • CCL-21 Conditioned Regulatory T Cells Induce Allotolerance through Enhanced Homing to Lymphoid Tissue 

      Chauhan, Sunil Kumar; Saban, Daniel R.; Dohlman, Thomas H.; Dana, Reza (The American Association of Immunologists, 2013)
      Regulatory T cells (Tregs) are instrumental in the induction and maintenance of tolerance, including in transplantation. Tregs induce allotolerance by interacting with antigen-presenting cells (APC) and T cells, interactions ...

    • CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function 

      Chun, Eunyoung; Lavoie, Sydney; Michaud, Monia; Gallini, Carey Ann; Kim, Jason; Soucy, Genevieve; Odze, Robert; Glickman, Jonathan N.; Garrett, Wendy S. (2015)
      Summary Our study reveals a non-canonical role for CCL2 in modulating non-macrophage, myeloid-derived suppressor cells (MDSCs) and shaping a tumor-permissive microenvironment during colon cancer development. We found that ...

    • CCL2/CCR2 Regulates the Tumor Microenvironment in HER-2/neu-Driven Mammary Carcinomas in Mice 

      Chen, Xuguang; Wang, Yunyue; Nelson, David; Tian, Sara; Mulvey, Erin; Patel, Bhumi; Conti, Ilaria; Jaen, Juan; Rollins, Barrett J. (Public Library of Science, 2016)
      Chronic inflammation is a hallmark of cancer. Inflammatory chemokines, such as C-C chemokine ligand 2 (CCL2), are often present in tumors but their roles in cancer initiation and maintenance are not clear. Here we report ...

    • CCN1 Secretion Induced by Cigarette Smoking Extracts Augments IL-8 Release from Bronchial Epithelial Cells 

      Moon, Hyung-Geun; Zheng, Yijie; An, Chang Hyeok; Kim, Yoon-Keun; Jin, Yang (Public Library of Science, 2013)
      Inflammation involves in many cigarette smoke (CS) related diseases including the chronic obstructive pulmonary disease (COPD). Lung epithelial cell released IL-8 plays a crucial role in CS induced lung inflammation. CS ...

    • CCR5 Chemokine Receptor Mediates Recruitment of MHC Class II-Positive Langerhans Cells in the Mouse Corneal Epithelium 

      Yamagami, Satoru; Hamrah, Pedram; Miyamoto, Kazuhisa; Miyazaki, Dai; Dekaris, Iva; Dawson, Tracey; Lu, Bao; Gerard, Craig; Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2005)
      purpose. To characterize the chemokines and chemokine receptors that mediate the effect of proinflammatory cytokines, interleukin (IL)-1 and tumor necrosis factor (TNF)-α, on the recruitment of MHC class II+ Langerhans ...

    • CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection 

      Khan, Imtiaz A; Thomas, Seddon Y; Moretto, Magali M; Lee, Frederick S; Islam, Sabina A.; Combe, Crescent; Schwartzman, Joseph D; Luster, Andrew David (Public Library of Science, 2006)
      The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate ...

    • CCR6, the Sole Receptor for the Chemokine CCL20, Promotes Spontaneous Intestinal Tumorigenesis 

      Nandi, Bisweswar; Pai, Christine; Huang, Qin; Prabhala, Rao H.; Munshi, Nikhil C.; Gold, Jason S. (Public Library of Science, 2014)
      Interactions between the inflammatory chemokine CCL20 and its receptor CCR6 have been associated with colorectal cancer growth and metastasis, however, a causal role for CCL20 signaling through CCR6 in promoting intestinal ...