Browsing HMS Scholarly Articles by Title
Now showing items 2216-2235 of 17922
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CCR5 Is Essential for NK Cell Trafficking and Host Survival following Toxoplasma gondii Infection
(Public Library of Science, 2006)The host response to intracellular pathogens requires the coordinated action of both the innate and acquired immune systems. Chemokines play a critical role in the trafficking of immune cells and transitioning an innate ... -
CCR6, the Sole Receptor for the Chemokine CCL20, Promotes Spontaneous Intestinal Tumorigenesis
(Public Library of Science, 2014)Interactions between the inflammatory chemokine CCL20 and its receptor CCR6 have been associated with colorectal cancer growth and metastasis, however, a causal role for CCL20 signaling through CCR6 in promoting intestinal ... -
The CCR6/CCL20 Axis Mediates Th17 Cell Migration to the Ocular Surface in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2013)Purpose. Th17 cells are believed to be the primary effector cells in the pathogenesis of dry eye disease (DED). However, the mechanisms by which Th17 cells migrate from the lymphoid tissues to the ocular surface are ... -
CCR7 Is Critical for the Induction and Maintenance of Th17 Immunity in Dry Eye Disease
(Association for Research in Vision and Ophthalmology (ARVO), 2014)Purpose. We characterized antigen-presenting cell (APC)–relevant chemokine receptor expression in dry eye disease (DED), and investigated the effect of topical CC chemokine receptor (CCR)-7 blockade specifically on Th17 ... -
CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells
(National Academy of Sciences, 2013)Bacterial toxins have evolved successful strategies for coopting host proteins to access the cytosol of host cells. Anthrax lethal factor (LF) enters the cytosol through pores in the endosomal membrane formed by anthrax ... -
CD1-restricted adaptive immune responses to Mycobacteria in human group 1 CD1 transgenic mice
(Rockefeller University Press, 2009)Group 1 CD1 (CD1a, CD1b, and CD1c)–restricted T cells recognize mycobacterial lipid antigens and are found at higher frequencies in Mycobacterium tuberculosis (Mtb)–infected individuals. However, their role and dynamics ... -
CD151-α3β1 integrin complexes are prognostic markers of glioblastoma and cooperate with EGFR to drive tumor cell motility and invasion
(Impact Journals LLC, 2015)Glioblastoma, one of the most aggressive forms of brain cancer, is featured by high tumor cell motility and invasiveness, which not only fuel tumor infiltration, but also enable escape from surgical or other clinical ... -
CD151-α3β1 integrin complexes suppress ovarian tumor growth by repressing slug-mediated EMT and canonical Wnt signaling
(Impact Journals LLC, 2014)Human ovarian cancer is diagnosed in the late, metastatic stages but the underlying mechanisms remain poorly understood. We report a surprising functional link between CD151-α3β1 integrin complexes and the malignancy of ... -
CD155/PVR Plays a Key Role in Cell Motility During Tumor Cell Invasion and Migration
(BioMed Central, 2004)Background: Invasion is an important early step of cancer metastasis that is not well understood. Developing therapeutics to limit metastasis requires the identification and validation of candidate proteins necessary for ... -
CD160Ig Fusion Protein Targets a Novel Costimulatory Pathway and Prolongs Allograft Survival
(Public Library of Science, 2013)CD160 is a cell surface molecule expressed by most NK cells and approximately 50% of CD8+ cytotoxic T lymphocytes. Engagement of CD160 by MHC class-I directly triggers a costimulatory signal to TCR-induced proliferation, ... -
CD1a autoreactive T cells recognize natural skin oils that function as headless antigens
(2014)CD1a autoreactive T cells are common in human blood and skin, but the search for natural autoantigens has been confounded by background T cell responses to CD1 proteins and self lipids. After capturing CD1a-lipid complexes, ... -
CD1b Tetramers Bind \(\alpha \beta\) T Cell Receptors to Identify a Mycobacterial Glycolipid-Reactive T Cell Repertoire in Humans
(The Rockefeller University Press, 2011)Microbial lipids activate T cells by binding directly to CD1 and T cell receptors (TCRs) or by indirect effects on antigen-presenting cells involving induction of lipid autoantigens, CD1 transcription, or cytokine release. ... -
CD1c Bypasses Lysosomes to Present a Lipopeptide Antigen with 12 Amino Acids
(The Rockefeller University Press, 2009)The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ... -
CD1c bypasses lysosomes to present a lipopeptide antigen with 12 amino acids
(The Rockefeller University Press, 2009)The recent discovery of dideoxymycobactin (DDM) as a ligand for CD1a demonstrates how a nonribosomal lipopeptide antigen is presented to T cells. DDM contains an unusual acylation motif and a peptide sequence present only ... -
CD2 regulates responsiveness of activated T cells to interleukin 12.
(Rockefeller University Press, 1995)Interleukin (IL) 12 is a 70-kD heterodimeric cytokine produced by antigen-presenting cells (APCs) such as macrophages in response to infectious pathogens and interferon (IFN) gamma. The varied immunomodulatory effects of ... -
CD200 increases alternatively activated macrophages through cAMP-response element binding protein - C/EBP-beta signaling
(Wiley, 2016)The concept of macrophage polarization toward different phenotypes after CNS injury has been increasingly discussed. Here, we propose that CD200 treatment may help shift pro-inflammatory macrophages to an arginase 1 (Arg1)-, ... -
CD200 restrains macrophage attack on oligodendrocyte precursors via toll-like receptor 4 downregulation
(SAGE Publications, 2016)There are numerous barriers to white matter repair after CNS injury and the underlying mechanisms remain to be fully understood. In this study, we propose the hypothesis that inflammatory macrophages in damaged white matter ... -
CD200R1 Supports HSV-1 Viral Replication and Licenses Pro-Inflammatory Signaling Functions of TLR2
(Public Library of Science, 2012)The CD200R1:CD200 axis is traditionally considered to limit tissue inflammation by down-regulating pro-inflammatory signaling in myeloid cells bearing the receptor. We generated CD200R1−/− mice and employed them to explore ... -
CD28 Costimulation Regulates Genome-Wide Effects on Alternative Splicing
(Public Library of Science, 2012)CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing ... -
CD28 Ligation Increases Macrophage Suppression of T Cell Proliferation
(Nature Publishing Group, 2012)When compared to spleen or lymph node cells, resident peritoneal cavity cells respond poorly to T cell activation in vitro. The greater proportional representation of macrophages in this cell source has been shown to ...