Browsing HMS Scholarly Articles by Title
Now showing items 272-291 of 17922
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Actin Disassembly by Cofilin, Coronin, and Aip1 Occurs in Bursts and Is Inhibited by Barbed-end Cappers
(The Rockefeller University Press, 2008)Turnover of actin filaments in cells requires rapid actin disassembly in a cytoplasmic environment that thermodynamically favors assembly because of high concentrations of polymerizable monomers. We here image the disassembly ... -
Actin foci facilitate activation of the phospholipase C-γ in primary T lymphocytes via the WASP pathway
(eLife Sciences Publications, Ltd, 2015)Wiscott Aldrich Syndrome protein (WASP) deficiency results in defects in calcium ion signaling, cytoskeletal regulation, gene transcription and overall T cell activation. The activation of WASP constitutes a key pathway ... -
Actin polymerization stabilizes α4β1 integrin anchors that mediate monocyte adhesion
(The Rockefeller University Press, 2012)Leukocytes arrested on inflamed endothelium via integrins are subjected to force imparted by flowing blood. How leukocytes respond to this force and resist detachment is poorly understood. Live-cell imaging with ... -
An Actin-Based Wave Generator Organizes Cell Motility
(Public Library of Science, 2007)Although many of the regulators of actin assembly are known, we do not understand how these components act together to organize cell shape and movement. To address this question, we analyzed the spatial dynamics of a key ... -
Actin-dependent mitochondrial internalization in cardiomyocytes: evidence for rescue of mitochondrial function
(The Company of Biologists, 2015)Previously, we have demonstrated that the transplantation of viable, structurally intact, respiration competent mitochondria into the ischemic myocardium during early reperfusion significantly enhanced cardioprotection by ... -
Actinobacillus actinomycetemcomitans Keratitis After Glaucoma Infiltration Surgery: A Clinical Report and Literature Review
(Wolters Kluwer Health, 2016)Abstract Actinobacillus actinomycetemcomitans infection is a rare and easily misdiagnosed ocular disease. In this article, the authors report a chronic, purulent, and difficult-to-treat case of A actinomycetemcomitans ... -
Action Initiation in the Human Dorsal Anterior Cingulate Cortex
(Public Library of Science, 2013)The dorsal anterior cingulate cortex (dACC) has previously been implicated in processes that influence action initiation. In humans however, there has been little direct evidence connecting dACC to the temporal onset of ... -
Action video game play and transfer of navigation and spatial cognition skills in adolescents who are blind
(Frontiers Media S.A., 2014)For individuals who are blind, navigating independently in an unfamiliar environment represents a considerable challenge. Inspired by the rising popularity of video games, we have developed a novel approach to train ... -
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
(Springer Science and Business Media LLC, 2021-04) -
Activated carbon for aerobic oxidation: Benign approach toward 2-benzoylbenzimidazoles and 2-benzoylbenzoxazoles synthesis
(Nature Publishing Group, 2015)A general strategy involving a novel and highly efficient aerobic benzylic oxidation promoted by cheap, reusable activated carbon in water is developed. Application of this method has been demonstrated in the benign synthesis ... -
Activated fibronectin-secretory phenotype of mesenchymal stromal cells in pre-fibrotic myeloproliferative neoplasms
(BioMed Central, 2014)We characterized bone marrow stromal cells (BMSC) from patients with pre-fibrotic myeloproliferative neoplasms (MPN). MPN-BMSC showed decreased capacity to stimulate the proliferation of colony-forming units of normal ... -
Activated Human CD4+CD45RO+ Memory T-Cells Indirectly Inhibit NLRP3 Inflammasome Activation through Downregulation of P2X7R Signalling
(Public Library of Science, 2012)Inflammasomes are multi-protein complexes that control the production of pro-inflammatory cytokines such as IL-1β. Inflammasomes play an important role in the control of immunity to tumors and infections, and also in ... -
Activated mouse \(CD4^+Foxp3^−\) T cells facilitate melanoma metastasis via Qa-1-dependent suppression of NK-cell cytotoxicity
(Nature Publishing Group, 2012)The regulatory activities of mouse \(CD^4+Foxp3^+\) T cells on various immune cells, including NK cells, have been well documented. Under some conditions, conventional \(CD4^+Foxp3^−\) T cells in the periphery are able to ... -
Activated N-Ras signaling regulates arterial-venous specification in zebrafish
(BioMed Central, 2013)Background: The aberrant activation of Ras signaling is associated with human diseases including hematological malignancies and vascular disorders. So far the pathological roles of activated Ras signaling in hematopoiesis ... -
Activated networking of platelet activating factor receptor and FAK/STAT1 induces malignant potential in BRCA1-mutant at-risk ovarian epithelium
(Springer Science + Business Media, 2010)Objectives It is essential to understand the molecular basis of ovarian cancer etiology and tumor development to provide more effective preventive and therapeutic approaches to reduce mortality. Particularly, the molecular ... -
Activating Fc γ receptors contribute to the antitumor activities of immunoregulatory receptor-targeting antibodies
(The Rockefeller University Press, 2013)Fc γ receptor (FcγR) coengagement can facilitate antibody-mediated receptor activation in target cells. In particular, agonistic antibodies that target tumor necrosis factor receptor (TNFR) family members have shown ... -
Activating Mutations in ERBB2 and Their Impact on Diagnostics and Treatment
(Frontiers Media S.A., 2013)Despite the ongoing “war on cancer,” cancer remains one of the major causes of human morbidity and mortality. A new paradigm of targeted therapies holds the most promise for the future, making identification of tumor-specific ... -
Activation During Sinus Rhythm in Ventricles With Healed Infarction
(Ovid Technologies (Wolters Kluwer Health), 2019-10)Background: In infarct-related ventricular tachycardia (VT), the circuit often corresponds to a location characterized by activation slowing during sinus rhythm (SR). However, the relationship between activation slowing ... -
Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity
(Impact Journals LLC, 2015)We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an underlying mechanism in the development of castrate-resistant cancer. While androgens inhibit apoptosis partly through transcriptional ... -
Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function
(2013)Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, ...