Browsing HMS Scholarly Articles by Title

Now showing items 289-308 of 17922

    • Activation During Sinus Rhythm in Ventricles With Healed Infarction 

      Rottmann, Markus; Kleber, Andre; Barkagan, Michael; Sroubek, Jakub; Leshem, Eran; Shapira-Daniels, Ayelet; Buxton, Alfred; Anter, Elad (Ovid Technologies (Wolters Kluwer Health), 2019-10)
      Background: In infarct-related ventricular tachycardia (VT), the circuit often corresponds to a location characterized by activation slowing during sinus rhythm (SR). However, the relationship between activation slowing ...

    • Activation of AKR1C1/ERβ induces apoptosis by downregulation of c-FLIP in prostate cancer cells: A prospective therapeutic opportunity 

      Yun, Huiyoung; Xie, Jianping; Olumi, Aria F.; Ghosh, Rita; Kumar, Addanki P. (Impact Journals LLC, 2015)
      We provide first-time evidence for ERβ-mediated transcriptional upregulation of c-FLIP as an underlying mechanism in the development of castrate-resistant cancer. While androgens inhibit apoptosis partly through transcriptional ...

    • Activation of caspase-1 by the NLRP3 inflammasome regulates the NADPH oxidase NOX2 to control phagosome function 

      Sokolovska, Anna; Becker, Christine E.; Eddie Ip, WK; Rathinam, Vijay A.K.; Brudner, Matthew; Paquette, Nicholas; Tanne, Antoine; Vanaja, Sivapriya K.; Moore, Kathryn J.; Fitzgerald, Katherine A.; Lacy-Hulbert, Adam; Stuart, Lynda M. (2013)
      Phagocytosis is a fundamental cellular process that is pivotal for immunity as it coordinates microbial killing, innate immune activation and antigen presentation. An essential step in this process is phagosome acidification, ...

    • Activation of Caspase-2 in Apoptosis 

      Li, Honglin; Bergeron, Louise; Cryns, Vince; Pasternack, Mark S.; Zhu, Hong; Shi, Lianfa; Greenberg, Arnold; Yuan, Junying (American Society for Biochemistry and Molecular Biology, 1997)

    • Activation of Cytomegalovirus in Pig-to-Primate Organ Xenotransplantation 

      Mueller, Nicolas; Barth, Rolf; Yamamoto, Shin; Kitamura, Hiroshi; Patience, Clive; Yamada, Kazuhiko; Cooper, David K. C.; Sachs, David H.; Kaur, Amitinder; Fishman, Jay Alan (American Society for Microbiology, 2002)
      Xenotransplantation of porcine organs carries the risk of reactivation of latent virus in donor and recipient tissues as well as transmission of viruses between species. We have investigated the activation of baboon ...

    • Activation of ERK1/2 by Store-Operated Calcium Entry in Rat Parotid Acinar Cells 

      Soltoff, Stephen P.; Lannon, William A. (Public Library of Science, 2013)
      The regulation of intracellular Ca2+ concentration ([Ca2+]i) plays a critical role in a variety of cellular processes, including transcription, protein activation, vesicle trafficking, and ion movement across epithelial ...

    • Activation of mechanosensitive ion channel TRPV4 normalizes tumor vasculature and improves cancer therapy 

      Adapala, Ravi K.; Thoppil, Roslin J.; Ghosh, Kaustabh; Cappelli, Holly; Dudley, Andrew C.; Paruchuri, Sailaja; Keshamouni, Venkateshwar; Klagsbrun, Michael; Meszaros, J. Gary; Chilian, William M.; Ingber, Donald E.; Thodeti, Charles K. (2016)
      Tumor vessels are characterized by abnormal morphology and hyper-permeability that together cause inefficient delivery of chemotherapeutic agents. Although VEGF has been established as a critical regulator of tumor ...

    • Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase 

      Sun, Tingting; Aceto, Nicola; Meerbrey, Kristen L.; Kessler, Jessica D.; Zhou, Chunshui; Migliaccio, Ilenia; Nguyen, Don X.; Pavlova, Natalya N.; Botero, Maria; Huang, Jian; Bernardi, Ronald J.; Schmitt, Earlene; Hu, Guang; Li, Mamie Z.; Dephoure, Noah; Rao, Mitchell; Creighton, Chad J.; Hilsenbeck, Susan G.; Shaw, Chad A.; Muzny, Donna; Gibbs, Richard A.; Wheeler, David A.; Osborne, C. Kent; Schiff, Rachel; Bentires-Alj, Mohamed; Westbrook, Thomas F.; Elledge, Stephen; Gygi, Steven (Elsevier BV, 2011-03)
      Among breast cancers, triple-negative breast cancer (TNBC) is the most poorly understood and is refractory to current targeted therapies. Using a genetic screen, we identify the PTPN12 tyrosine phosphatase as a tumor ...

    • Activation of necroptosis in human and experimental cholestasis 

      Afonso, Marta B; Rodrigues, Pedro M; Simão, André L; Ofengeim, Dimitry; Carvalho, Tânia; Amaral, Joana D; Gaspar, Maria M; Cortez-Pinto, Helena; Castro, Rui E; Yuan, Junying; Rodrigues, Cecília M P (Nature Publishing Group, 2016)
      Cholestasis encompasses liver injury and inflammation. Necroptosis, a necrotic cell death pathway regulated by receptor-interacting protein (RIP) 3, may mediate cell death and inflammation in the liver. We aimed to investigate ...

    • Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1 

      Zhu, Jidong; Blenis, John; Yuan, Junying (National Academy of Sciences, 2008)
      Mad1, a member of the Myc/Max/Mad family, suppresses Myc-mediated transcriptional activity by competing with Myc for heterodimerization with its obligatory partner, Max. The expression of Mad1 suppresses Myc-mediated cell ...

    • Activation of PI3K/mTOR Pathway Occurs in Most Adult Low-Grade Gliomas and Predicts Patient Survival 

      Perez, Daniel A.; Polley, Mei-Yin; Vandenberg, Scott R.; Zheng, Shichun; Lamborn, Kathleen R.; Wiencke, John K.; Chang, Susan M.; Prados, Michael D.; Berger, Mitchel S.; Stokoe, David; Haas-Kogan, Daphne A.; McBride, Sean Matthew; Smith, Justin S. (Springer US, 2009)
      Recent evidence suggests the Akt-mTOR pathway may play a role in development of low-grade gliomas (LGG). We sought to evaluate whether activation of this pathway correlates with survival in LGG by examining expression ...

    • Activation of PKC-δ and SHP-1 by hyperglycemia causes vascular cell apoptosis and diabetic retinopathy 

      Geraldes, Pedro; Hiraoka-Yamamoto, Junko; Matsumoto, Motonobu; Clermont, Allen Charles; Leitges, Michael; Marette, Andre; Aiello, Lloyd Paul; Kern, Timothy S; King, George Liang (Nature Publishing Group, 2009)
      Cellular apoptosis induced by hyperglycemia occurs in many vascular cells and is crucial for the initiation of diabetic pathologies. In the retina, pericyte apoptosis and the formation of acellular capillaries, the most ...

    • Activation of the central nervous system induced by micro-magnetic stimulation 

      Park, Hyun-Joo; Bonmassar, Giorgio; Kaltenbach, James A.; Machado, Andre G.; Manzoor, Nauman F.; Gale, John T. (2013)
      Electrical and transcranial magnetic stimulation have proven to be therapeutically beneficial for patients suffering from neurological disorders. Moreover, these stimulation technologies have provided invaluable tools for ...

    • Activation of the Connective Tissue Growth Factor (CTGF)-Transforming Growth Factor β 1 (TGF-β 1) Axis in Hepatitis C Virus-Expressing Hepatocytes 

      Nagaraja, Tirumuru; Chen, Li; Balasubramanian, Anuradha; Groopman, Jerome Elliot; Ghoshal, Kalpana; Jacob, Samson T.; Leask, Andrew; Brigstock, David R.; Anand, Appakkudal R.; Ganju, Ramesh K. (Public Library of Science, 2012)
      Background: The pro-fibrogenic cytokine connective tissue growth factor (CTGF) plays an important role in the development and progression of fibrosis in many organ systems, including liver. However, its role in the ...

    • Activation of the JNK Pathway During Dorsal Closure in Drosophila Requires the Mixed Lineage Kinase, Slipper 

      Stronach, Beth E.; Perrimon, Norbert (Cold Spring Harbor Laboratory, 2002-02-01)
      The Jun kinase (JNK) pathway has been characterized for its role in stimulating AP-1 activity and for modulating the balance between cell growth and death during development, inflammation, and cancer. Six families of ...

    • Activation of the Nrf2 Cell Defense Pathway by Ancient Foods: Disease Prevention by Important Molecules and Microbes Lost from the Modern Western Diet 

      Senger, Donald R.; Li, Dan; Jaminet, Shou-Ching; Cao, Shugeng (Public Library of Science, 2016)
      The Nrf2 (NFE2L2) cell defense pathway protects against oxidative stress and disorders including cancer and neurodegeneration. Although activated modestly by oxidative stress alone, robust activation of the Nrf2 defense ...

    • Activation of the PD-1 Pathway Contributes to Immune Escape in EGFR-Driven Lung Tumors 

      Akbay, E; Koyama, S.; Carretero, J.; Altabef, A.; Tchaicha, J. H.; Christensen, Camilla Laulund; Mikse, O. R.; Cherniack, Andrew David; Beauchamp, Ellen Monica; Pugh, T; Wilkerson, M. D.; Fecci, P; Butaney, M.; Reibel, J. B.; Soucheray, M.; Cohoon, T. J.; Janne, Pasi Antero; Meyerson, Matthew Langer; Hayes, D. N.; Shapiro, Geoffrey Ira; Shimamura, T; Sholl, Lynette Marie; Rodig, Scott J.; Freeman, Gordon James; Hammerman, Peter Seth; Dranoff, G; Wong, Kwok-Kin (American Association for Cancer Research (AACR), 2013)
      The success in lung cancer therapy with Programmed Death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We identified a correlation between Epidermal Growth Factor Receptor ...

    • Activation of TRPC6 Channels Is Essential for Lung Ischaemia–Reperfusion Induced Oedema in Mice 

      Weissmann, Norbert; Sydykov, Akylbek; Storch, Ursula; Fuchs, Beate; Schnitzler, Michael Mederos y; Brandes, Ralf P.; Grimminger, Friedrich; Meissner, Marcel; Freichel, Marc; Offermanns, Stefan; Veit, Florian; Pak, Oleg; Krause, Karl-Heinz; Schermuly, Ralph T.; Brewer, Alison C; Schmidt, Harald H.H.W.; Seeger, Werner; Gudermann, Thomas; Ghofrani, Hossein A.; Dietrich, Alexander; Kalwa, Hermann H; Shah, Ajay Mukesh (Nature Publishing Group, 2012)
      Lung ischaemia–reperfusion-induced oedema (LIRE) is a life-threatening condition that causes pulmonary oedema induced by endothelial dysfunction. Here we show that lungs from mice lacking nicotinamide adenine dinucleotide ...

    • Activation of β-Catenin Signaling in Prostate Cancer by Peptidyl-Prolyl Isomerase Pin1-Mediated Abrogation of the Androgen Receptor-β-Catenin Interaction 

      Chen, Shao-Yong; Wulf, Gerburg; Zhou, Xiao Zhen; Rubin, Mark A.; Lu, Kun Ping; Balk, Steven P. (American Society for Microbiology, 2006)

    • Active Albuterol or Placebo, Sham Acupuncture, or No Intervention in Asthma 

      Wechsler, Michael E.; Kelley, John; Boyd, Ingrid O.E.; Dutile, Stefanie; Marigowda, Gautham; Kirsch, Irving; Israel, Elliot; Kaptchuk, Ted (Massachusetts Medical Society, 2011-07-14)
      BACKGROUND In prospective experimental studies in patients with asthma, it is difficult to determine whether responses to placebo differ from the natural course of physiological changes that occur without any intervention. ...