Browsing HMS Scholarly Articles by Title

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    • Complementary and Alternative Medical Therapies in Multiple Sclerosis–The American Academy of Neurology Guidelines: A Commentary 

      Yadav, Vijayshree; Narayanaswami, Pushpa (Elsevier BV, 2014)
      Background: Complementary and alternative med- icine (CAM) use in individuals with multiple sclerosis (MS) is common, but its use has been limited by a lack of evidence-based guidance. Methods: In March 2014, the American ...

    • Complementary Genomic Screens Identify SERCA as a Therapeutic Target in NOTCH1 Mutated Cancer 

      Roti, Giovanni; Carlton, Anne; Ross, Kenneth; Markstein, Michele; Pajcini, Kostandin; Su, Angela H.; Perrimon, Norbert; Pear, Warren S.; Kung, Andrew L.; Blacklow, Stephen; Aster, Jon; Stegmaier, Kimberly (Elsevier BV, 2013-03-18)
      Notch1 is a rational therapeutic target in several human cancers, but as a transcriptional regulator, it poses a drug discovery challenge. To identify Notch1 modulators, we performed two cell-based, high-throughput screens ...

    • Complementary Medicine, Exercise, Meditation, Diet, and Lifestyle Modification for Anxiety Disorders: A Review of Current Evidence 

      Sarris, J.; Moylan, S.; Camfield, D. A.; Pase, M. P.; Mischoulon, David; Berk, M.; Jacka, F. N.; Schweitzer, I. (Hindawi Publishing Corporation, 2012)
      Use of complementary medicines and therapies (CAM) and modification of lifestyle factors such as physical activity, exercise, and diet are being increasingly considered as potential therapeutic options for anxiety disorders. ...

    • Complete and Partial Responses of the TEMPI Syndrome to Bortezomib 

      Schroyens, Wilfried; O'Connell, Casey; Sykes, David Brian (New England Journal of Medicine (NEJM/MMS), 2012)

    • Complete Androgen Insensitivity Syndrome 

      Sullivan, Benjamin; Evans, James E.; Cermack, Jennifer M.; Dana, Reza; Sullivan, David A. (American Medical Association (AMA), 2002)
      Objective To determine whether androgen receptors affect the fatty acid profiles of neutral and polar lipids in human meibomian gland secretions. Methods Meibomian gland secretion samples were obtained from both eyes ...

    • Complete Genes May Pass from Food to Human Blood 

      Spisák, Sándor; Solymosi, Norbert; Ittzés, Péter; Bodor, András; Kondor, Dániel; Vattay, Gábor; Barták, Barbara K.; Sipos, Ferenc; Galamb, Orsolya; Tulassay, Zsolt; Szállási, Zoltán; Rasmussen, Simon; Sicheritz-Ponten, Thomas; Brunak, Søren; Molnár, Béla; Csabai, István (Public Library of Science, 2013)
      Our bloodstream is considered to be an environment well separated from the outside world and the digestive tract. According to the standard paradigm large macromolecules consumed with food cannot pass directly to the ...

    • The Complete Genome and Proteome of Mycoplasma mobile 

      Jaffe, JD; Stange-Thomann, N; Smith, C; DeCaprio, D; Fisher, S; Butler, J; Calvo, S; Elkins, T; FitzGerald, MG; Hafez, N; Kodira, CD; Major, J; Wang, S; Wilkinson, J; Nicol, R; Nusbaum, C; Birren, B; Berg, HC; Church, George (Cold Spring Harbor Laboratory, 2004-08)
      Although often considered “minimal” organisms, mycoplasmas show a wide range of diversity with respect to host environment, phenotypic traits, and pathogenicity. Here we report the complete genomic sequence and proteogenomic ...

    • Complete genome of Staphylococcus aureus Tager 104 provides evidence of its relation to modern systemic hospital-acquired strains 

      Davis, Richard W.; Brannen, Andrew D.; Hossain, Mohammad J.; Monsma, Scott; Bock, Paul E.; Nahrendorf, Matthias; Mead, David; Lodes, Michael; Liles, Mark R.; Panizzi, Peter (BioMed Central, 2016)
      Background: Staphylococcus aureus (S. aureus) infections range in severity due to expression of certain virulence factors encoded on mobile genetic elements (MGE). As such, characterization of these MGE, as well as single ...

    • The complete genome sequence of a Neandertal from the Altai Mountains 

      Prüfer, Kay; Racimo, Fernando; Patterson, Nick; Jay, Flora; Sankararaman, Sriram; Sawyer, Susanna; Heinze, Anja; Renaud, Gabriel; Sudmant, Peter H.; de Filippo, Cesare; Li, Heng; Mallick, Swapan; Dannemann, Michael; Fu, Qiaomei; Kircher, Martin; Kuhlwilm, Martin; Lachmann, Michael; Meyer, Matthias; Ongyerth, Matthias; Siebauer, Michael; Theunert, Christoph; Tandon, Arti; Moorjani, Priya; Pickrell, Joseph; Mullikin, James C.; Vohr, Samuel H.; Green, Richard E.; Hellmann, Ines; Johnson, Philip L. F.; Blanche, Hélène; Cann, Howard; Kitzman, Jacob O.; Shendure, Jay; Eichler, Evan E.; Lein, Ed S.; Bakken, Trygve E.; Golovanova, Liubov V.; Doronichev, Vladimir B.; Shunkov, Michael V.; Derevianko, Anatoli P.; Viola, Bence; Slatkin, Montgomery; Reich, David; Kelso, Janet; Pääbo, Svante (2014)
      We present a high-quality genome sequence of a Neandertal woman from Siberia. We show that her parents were related at the level of half siblings and that mating among close relatives was common among her recent ancestors. ...

    • Complete Genome Sequence of Linezolid-Susceptible Staphylococcus haemolyticus Sh29/312/L2, a Clonal Derivative of a Linezolid-Resistant Clinical Strain 

      de Almeida, Lara M.; Pires, Carlos; Cerdeira, Louise T.; de Oliveira, Théo G. M.; McCulloch, John Anthony; Perez-Chaparro, Paula Juliana; Sacramento, Andrey G.; Brito, Artemir C.; da Silva, Joás L.; de Araújo, Maria Rita E.; Lincopan, Nilton; Martin, Melissa J.; Gilmore, Michael S.; Mamizuka, Elsa M. (American Society for Microbiology, 2015)
      We report the whole-genome sequence (WGS) of an in vitro susceptible derivative revertant mutant from a bloodstream isolate involved in a nosocomial outbreak in Brazil. The WGS comprises 2.5 Mb with 2,500 protein-coding ...

    • Complete Genome Sequence of Methanobacterium Thermoautotrophicum deltaH: Functional Analysis and Comparative Genomics 

      Smith, Douglas R.; Doucette-Stamm, Lynn; Deloughery, Craig; Lee, Hongmei; Dubois, Joann; Aldredge, Tyler; Bashirzadeh, Romina; Blakely, Derron; Cook, Robin; Gilbert, Katie; Keagle, Pamela; Hoang, Lieu; Harrison, Dawn; Lumm, Wendy; Pothier, Bryan; Qiu, Dayong; Spadafora, Rob; Vicaire, Rita; Wang, Ying; Wierzbowski, Jamey; Gibson, Rene; Jiwani, Nilofer; Caruso, Anthony; Bush, David; Safer, Hershel; Patwell, Donivan; Prabhakar, Shashi; McDougall, Steven; Shimer, George; Goyal, Anil; Pietrokovski, Shmuel; Church, George; Daniels, Charles; Mao, Jen-i; Rice, Phil; Nolling, Jork; Reeve, John (American Society for Microbiology, 1997)
      The complete 1,751,377-bp sequence of the genome of the thermophilic archaeon Methanobacterium thermoautotrophicum deltaH has been determined by a whole-genome shotgun sequencing approach. A total of 1,855 open reading ...

    • Complete Genome Sequence of Pseudomonas aeruginosa Phage AAT-1 

      Andrade-Domínguez, Andrés; Kolter, Roberto (American Society for Microbiology, 2016)
      Aspects of the interaction between phages and animals are of interest and importance for medical applications. Here, we report the genome sequence of the lytic Pseudomonas phage AAT-1, isolated from mammalian serum. AAT-1 ...

    • Complete Genome Sequences of T4-Like Bacteriophages RB3, RB5, RB6, RB7, RB9, RB10, RB27, RB33, RB55, RB59, and RB68 

      Yaung, Stephanie J.; Esvelt, Kevin M.; Church, George M. (American Society for Microbiology, 2015)
      T4-like bacteriophages have been explored for phage therapy and are model organisms for phage genomics and evolution. Here, we describe the sequencing of 11 T4-like phages. We found a high nucleotide similarity among the ...

    • Complete hematologic response of early T-cell progenitor acute lymphoblastic leukemia to the γ-secretase inhibitor BMS-906024: genetic and epigenetic findings in an outlier case 

      Knoechel, Birgit; Bhatt, Ami; Pan, Li; Pedamallu, Chandra S.; Severson, Eric; Gutierrez, Alejandro; Dorfman, David M.; Kuo, Frank C.; Kluk, Michael; Kung, Andrew L.; Zweidler-McKay, Patrick; Meyerson, Matthew; Blacklow, Stephen C.; DeAngelo, Daniel J.; Aster, Jon C. (Cold Spring Harbor Laboratory Press, 2015)
      Notch pathway antagonists such as γ-secretase inhibitors (GSIs) are being tested in diverse cancers, but exceptional responses have yet to be reported. We describe the case of a patient with relapsed/refractory early T-cell ...

    • Complete integration of carbene-transfer chemistry into biosynthesis 

      Huang, Jing; Quest, Andrew; Cruz-Morales, Pablo; Deng, Kai; Pereira, Jose Henrique; Van Cura, Devon; Kakumanu, Ramu; Baidoo, Edward E. K.; Dan, Qingyun; Chen, Yan; Petzold, Christopher J.; Northen, Trent R.; Adams, Paul D.; Clark, Douglas S.; Balskus, Emily; Hartwig, John F.; Mukhopadhyay, Aindrila; Keasling, Jay D. (Springer Science and Business Media LLC, 2023-05-03)

    • Complete integrin headpiece opening in eight steps 

      Zhu, Jieqing; Zhu, Jianghai; Springer, Timothy A. (The Rockefeller University Press, 2013)
      Carefully soaking crystals with Arg-Gly-Asp (RGD) peptides, we captured eight distinct RGD-bound conformations of the αIIbβ3 integrin headpiece. Starting from the closed βI domain conformation, we saw six intermediate βI ...

    • The complex and specific pMHC interactions with diverse HIV-1 TCR clonotypes reveal a structural basis for alterations in CTL function 

      Xia, Zhen; Chen, Huabiao; Kang, Seung-gu; Huynh, Tien; Fang, Justin W.; Lamothe, Pedro A.; Walker, Bruce D.; Zhou, Ruhong (Nature Publishing Group, 2014)
      Immune control of viral infections is modulated by diverse T cell receptor (TCR) clonotypes engaging peptide-MHC class I complexes on infected cells, but the relationship between TCR structure and antiviral function is ...

    • Complex Breakpoints and Template Switching Associated with Non-canonical Termination of Homologous Recombination in Mammalian Cells 

      Hartlerode, Andrea J.; Willis, Nicholas A.; Rajendran, Anbazhagan; Manis, John P.; Scully, Ralph (Public Library of Science, 2016)
      A proportion of homologous recombination (HR) events in mammalian cells resolve by “long tract” gene conversion, reflecting copying of several kilobases from the donor sister chromatid prior to termination. Cells lacking ...

    • Complex cytogenetic rearrangements at the DURS1 locus in syndromic Duane retraction syndrome 

      Baris, Hagit N; Chan, Wai-Man; Andrews, Caroline; Behar, Doron M; Donovan, Diana J; Morton, Cynthia C; Ranells, Judith; Pal, Tuya; Ligon, Azra H; Engle, Elizabeth C (Blackwell Publishing Ltd, 2013)
      Key Clinical Message A patient with syndromic Duane retraction syndrome harbors a chromosome 811.1q13.2 inversion and 8p11.1-q12.3 marker chromosome containing subregions with differing mosaicism and allele frequencies. ...

    • Complex Effects of Rexinoids on Ligand Dependent Activation or Inhibition of the Xenobiotic Receptor, CAR 

      Tzameli, Iphigenia; Chua, Steven S; Cheskis, Boris; Moore, David D (BioMed Central, 2003)
      Background: CAR/RXR heterodimers bind a variety of hormone response elements and activate transcription in the absence of added ligands. This constitutive activity of murine CAR can be inhibited by the inverse agonist ...