Browsing HMS Scholarly Articles by Title

Now showing items 3407-3426 of 17922

    • Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes 

      Plotkin, Lilian I.; Galli, Carlo; Goellner, Joseph J.; Gortazar, Arancha R.; Allen, Matthew R.; Robling, Alexander G.; Turner, Charles H.; Jilka, Robert L.; Weinstein, Robert S.; Manolagas, Stavros C.; Bellido, Teresita; O'Brien, Charles A.; Bouxsein, Mary Larsen; Schipani, Ernestina (Public Library of Science, 2008)
      Osteocytes, former osteoblasts buried within bone, are thought to orchestrate skeletal adaptation to mechanical stimuli. However, it remains unknown whether hormones control skeletal homeostasis through actions on osteocytes. ...

    • Control of Breathing in Children With Mild Sleep Apnoea: A 6-Year Follow-Up Study 

      Rice, Amber; Costy-Bennett, Seres; Goodwin, James; Quan, Stuart; Fregosi, Ralph F (European Respiratory Society (ERS), 2010-01)
      We have previously shown that children (average age 9 yrs) with mildly elevated obstructive apnoea/hypopnoea indices (OAHI) retained CO(2) at rest. Here, we report the results of a 6-yr follow-up study on 14 children from ...

    • Control of Cell Fate Determination by p21ras/Ras1, an Essential Component of Torso Signaling in Drosophila 

      Lu, Xiangyi; Chou, Tze-Bin; Williams, Nidhi Gupta; Roberts, Thomas; Perrimon, Norbert (Cold Spring Harbor Laboratory, 1993-04-01)
      Determination of cell fate at the posterior termini of the Drosophila embryo is specified by the activation of the torso (tor) receptor tyrosine kinase. This signaling pathway is mediated by the serine/threonine kinase ...

    • Control of IBMIR in Neonatal Porcine Islet Xenotransplantation in Baboons 

      Hawthorne, W J; Salvaris, E J; Phillips, P; Hawkes, J; Liuwantara, D; Burns, H; Barlow, H; Stewart, A B; Peirce, S B; Hu, M; Lew, A M; Robson, S C; Nottle, M B; D'Apice, A J F; O'Connell, P J; Cowan, P J (Blackwell Publishing Ltd, 2014)
      The instant blood-mediated inflammatory reaction (IBMIR) is a major obstacle to the engraftment of intraportal pig islet xenografts in primates. Higher expression of the galactose-α1,3-galactose (αGal) xenoantigen on ...

    • Control of Lipid Metabolism by Tachykinin in Drosophila 

      Song, Wei; Veenstra, Jan A.; Perrimon, Norbert (Elsevier BV, 2014-10-09)
      The intestine is a key organ for lipid uptake and distribution, and abnormal intestinal lipid metabolism is associated with obesity and hyperlipidemia. Although multiple regulatory gut hormones secreted from enteroendocrine ...

    • Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling 

      Charbonnier, Louis-Marie; Wang, Sen; Georgiev, Peter; Sefik, Esen; Chatila, Talal A (2015)
      Notch receptors direct the differentiation of T helper (TH) cell subsets, but their influence on regulatory T (Treg) cell responses is obscure. We here report that lineage-specific deletion of components of the Notch pathway ...

    • Control of Proinflammatory Gene Programs by Regulated Trimethylation and Demethylation of Histone H4K20 

      Stender, Joshua D.; Pascual, Gabriel; Liu, Wen; Kaikkonen, Minna U.; Do, Kevin; Spann, Nathanael J.; Boutros, Michael; Perrimon, Norbert; Rosenfeld, Michael G.; Glass, Christopher K. (Elsevier BV, 2012-10-12)
      Regulation of genes that initiate and amplify inflammatory programs of gene expression is achieved by signal-dependent exchange of co-regulator complexes that function to read, write and erase specific histone modifications ...

    • Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53 

      Yoon, K. W.; Byun, S.; Kwon, Eunjeong; Hwang, So-Young; Chu, Kiki; Hiraki, Masatsugu; Jo, Seung-Hee; Weins, Astrid; Hakroush, Samy; Cebulla, Angelika; Sykes, David Brian; Greka, Anna; Mundel, Peter; Fisher, David E.; Mandinova, Anna; Lee, Sam Whan (American Association for the Advancement of Science (AAAS), 2015)
      The inefficient clearance of dying cells can lead to abnormal immune responses, such as unresolved inflammation and autoimmune conditions. We show that tumor suppressor p53 controls signaling-mediated phagocytosis of ...

    • Control of steroid receptor dynamics and function by genomic actions of the cochaperones p23 and Bag-1L 

      Cato, Laura; Neeb, Antje; Brown, Myles; Cato, Andrew C. B. (Nuclear Receptor Signaling Atlas, 2014)
      Molecular chaperones encompass a group of unrelated proteins that facilitate the correct assembly and disassembly of other macromolecular structures, which they themselves do not remain a part of. They associate with a ...

    • Control of Stomach Smooth Muscle Development and Intestinal Rotation by Transcription Factor BARX1 

      Jayewickreme, Chenura D.; Shivdasani, Ramesh Arjun (Elsevier BV, 2015-09-01)
      Diverse functions of the homeodomain transcription factor BARX1 include Wnt-dependent, non-cell autonomous specification of the stomach epithelium, tracheo-bronchial septation, and Wnt-independent expansion of the spleen ...

    • Control of T Helper Cell Differentiation through Cytokine Receptor Inclusion in the Immunological Synapse 

      Maldonado, Roberto A.; Soriano, Michelle A.; Perdomo, L. Carolina; Sigrist, Kirsten; Irvine, Darrell J.; Decker, Thomas; Glimcher, Laurie Hollis (The Rockefeller University Press, 2009)
      The antigen recognition interface formed by T helper precursors (Thps) and antigen-presenting cells (APCs), called the immunological synapse (IS), includes receptors and signaling molecules necessary for Thp activation and ...

    • Control of the innate immune response by the mevalonate pathway 

      Akula, Murali K.; Shi, Man; Jiang, Zhaozhao; Foster, Celia E.; Miao, David; Li, Annie S.; Zhang, Xiaoman; Gavin, Ruth M.; Forde, Sorcha D.; Germain, Gail; Carpenter, Susan; Rosadini, Charles V.; Gritsman, Kira; Chae, Jae Jin; Hampton, Randolph; Silverman, Neal; Gravallese, Ellen M.; Kagan, Jonathan C.; Fitzgerald, Katherine A.; Kastner, Daniel L.; Golenbock, Douglas T.; Bergo, Martin O.; Wang, Donghai (2016)
      Deficiency of mevalonate kinase (MVK) causes systemic inflammation. However, the molecular mechanisms linking the mevalonate pathway to inflammation remain obscure. Geranylgeranyl pyrophosphate (GGPP), a non-sterol ...

    • Control of Transcription by Cell Size 

      Wu, Chia-Yung; Rolfe, P. Alexander; Gifford, David K.; Fink, Gerald R.; Elledge, Stephen J. (Public Library of Science, 2010)
      Cell size increases significantly with increasing ploidy. Differences in cell size and ploidy are associated with alterations in gene expression, although no direct connection has been made between cell size and transcription. ...

    • Controllability Modulates the Anticipatory Response in the Human Ventromedial Prefrontal Cortex 

      Kerr, Deborah L.; McLaren, Donald G.; Mathy, Robin M.; Nitschke, Jack B. (Frontiers Media S.A., 2012)
      Research has consistently shown that control is critical to psychological functioning, with perceived lack of control considered to play a crucial role in the manifestation of symptoms in psychiatric disorders. In a model ...

    • Controlled delivery of bioactive molecules into live cells using the bacterial mechanosensitive channel MscL 

      Doerner, Julia; Febvay, Sebastien; Clapham, David Eldon (2013)
      Bacterial mechanosensitive channels are some of the largest pores in nature. In particular, MscL, with a pore diameter > 25 Å, allows passage of large organic ions and small proteins. Functional MscL reconstitution into ...

    • Controlled DNA double-strand break induction in mice reveals post-damage transcriptome stability 

      Kim, Jeongkyu; Sturgill, David; Tran, Andy D.; Sinclair, David A.; Oberdoerffer, Philipp (Oxford University Press, 2016)
      DNA double-strand breaks (DSBs) and their repair can cause extensive epigenetic changes. As a result, DSBs have been proposed to promote transcriptional and, ultimately, physiological dysfunction via both cell-intrinsic ...

    • Controlled electromechanical cell stimulation on-a-chip 

      Pavesi, Andrea; Adriani, Giulia; Rasponi, Marco; Zervantonakis, Ioannis K.; Fiore, Gianfranco B.; Kamm, Roger D. (Nature Publishing Group, 2015)
      Stem cell research has yielded promising advances in regenerative medicine, but standard assays generally lack the ability to combine different cell stimulations with rapid sample processing and precise fluid control. In ...

    • Controlled Exposure Study of Air Pollution and T-Wave Alternans in Volunteers without Cardiovascular Disease 

      Kusha, Marjan; Masse, Stephane; Farid, Talha; Urch, Bruce; Silverman, Frances; Brook, Robert D; Mangat, Iqwal; Speck, Mary; Nair, Krishnakumar; Poku, Kwaku; Wellenius, Gregory A; Nanthakumar, Kumaraswamy; Gold, Diane R.; Chris, Meyer; Mittleman, Murray A. (National Institute of Environmental Health Sciences, 2012)
      Background: Epidemiological studies have assessed T-wave alternans (TWA) as a possible mechanism of cardiac arrhythmias related to air pollution in high-risk subjects and have reported associations with increased TWA ...

    • Controlled Growth of Filamentous Fatty Acid Vesicles under Flow 

      Hentrich, Christian; Szostak, Jack W. (American Chemical Society, 2014)
      The earliest forms of cellular life would have required a membrane compartment capable of growth and division. Fatty acid vesicles are an attractive model of protocell membranes, as they can grow into filamentous vesicles ...

    • Controlled induction of distributed microdeformation in wounded tissue via a microchamber array dressing 

      Kane, Bartholomew J.; Younan, George; Helm, Douglas; Dastouri, Pouya; Prentice-Mott, Harrison; Irimia, Daniel; Chan, Rodney K.; Toner, Mehmet; Orgill, Dennis Paul (Wiley-Blackwell, 2010)
      Mechanical stimuli are known to play an important role in determining the structure and function of living cells and tissues. Recent studies have highlighted the role of mechanical signals in mammalian dermal wound healing. ...