Now showing items 3447-3466 of 17918

    • Cooperative benefit for the combination of rapamycin and imatinib in tuberous sclerosis complex neoplasia 

      Govindarajan, Baskaran; Willoughby, Laura; Band, Hamid; Curatolo, Adam S; Veledar, Emir; Chen, Suephy; Bonner, Michael Y.; Abel, Martin-Garrido; Moses, Marsha; Arbiser, Jack L (BioMed Central, 2012)
      Tuberous sclerosis (TS) is a common autosomal-dominant disorder characterized by tumors of the skin, lung, brain, and kidneys. Monotherapy with rapamycin however resulted in partial regression of tumors, implying the ...
    • Cooperative Gating between Single HCN Pacemaker Channels 

      Dekker, John P.; Yellen, Gary (Rockefeller University Press, 2006)
      HCN pacemaker channels (I(f), I(q), or I(h)) play a fundamental role in the physiology of many excitable cell types, including cardiac myocytes and central neurons. While cloned HCN channels have been studied extensively ...
    • Cooperative Interaction between Phosphorylation Sites on PERIOD Maintains Circadian Period in Drosophila 

      Garbe, David S.; Fang, Yanshan; Zheng, Xiangzhong; Sowcik, Mallory; Anjum, Rana; Gygi, Steven P.; Sehgal, Amita (Public Library of Science, 2013)
      Circadian rhythms in Drosophila rely on cyclic regulation of the period (per) and timeless (tim) clock genes. The molecular cycle requires rhythmic phosphorylation of PER and TIM proteins, which is mediated by several ...
    • Cooperative Interaction between the MUC1-C Oncoprotein and the Rab31 GTPase in Estrogen Receptor-Positive Breast Cancer Cells 

      Jin, Caining; Rajabi, Hasan Nabeel; Pitroda, Sean; Li, Ailing; Kharbanda, Akriti; Weichselbaum, Ralph; Kufe, Donald William (Public Library of Science, 2012)
      Rab31 is a member of the Ras superfamily of small GTPases that has been linked to poor outcomes in patients with breast cancer. The MUC1-C oncoprotein is aberrantly overexpressed in most human breast cancers and also confers ...
    • Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels 

      Wang, Weiwei; Touhara, Kouki K; Weir, Keiko; Bean, Bruce P; MacKinnon, Roderick (eLife Sciences Publications, Ltd, 2016)
      G protein gated inward rectifier K+ (GIRK) channels open and thereby silence cellular electrical activity when inhibitory G protein coupled receptors (GPCRs) are stimulated. Here we describe an assay to measure neuronal ...
    • Coordinated Control of Notch/Delta Signalling and Cell Cycle Progression Drives Lateral Inhibition-Mediated Tissue Patterning 

      Hunter, Ginger L.; Hadjivasiliou, Zena; Bonin, Hope; He, Li; Perrimon, Norbert; Charras, Guillaume; Baum, Buzz (The Company of Biologists, 2016-07-01)
      Coordinating cell differentiation with cell growth and division is crucial for the successful development, homeostasis and regeneration of multicellular tissues. Here, we use bristle patterning in the fly notum as a model ...
    • Coordinated integrin activation by actin-dependent force during T-cell migration 

      Nordenfelt, Pontus; Elliott, Hunter L.; Springer, Timothy A. (Nature Publishing Group, 2016)
      For a cell to move forward it must convert chemical energy into mechanical propulsion. Force produced by actin polymerization can generate traction across the plasma membrane by transmission through integrins to their ...
    • Coordinated patterns of gene expression for substrate and energy metabolism in skeletal muscle of diabetic mice 

      Yechoor, Vijay K.; Patti, Mary-Elizabeth; Saccone, Robert; Kahn, C. Ronald (National Academy of Sciences, 2002)
      Metabolic abnormalities underlying diabetes are primarily the result of the lack of adequate insulin action and the associated changes in protein phosphorylation and gene expression. To define the full set of alterations ...
    • Coordinated regulation of bidirectional COPI transport at the Golgi by cdc42 

      Park, Seung-Yeol; Yang, Jia-Shu; Schmider, Angela B.; Soberman, Roy J.; Hsu, Victor W. (2015)
      The Golgi complex plays a central role in the intracellular sorting of secretory proteins 1,2. Anterograde transport through the Golgi has been explained by the movement of Golgi cisternae, known as cisternal maturation ...
    • Coordinated transcriptional regulation of bone homeostasis by Ebf1 and Zfp521 in both mesenchymal and hematopoietic lineages 

      Kiviranta, Riku; Yamana, Kei; Saito, Hiroaki; Ho, Daniel K.; Laine, Julius; Tarkkonen, Kati; Nieminen-Pihala, Vappu; Hesse, Eric; Correa, Diego; Määttä, Jorma; Tessarollo, Lino; Rosen, Evan D.; Horne, William C.; Jenkins, Nancy A.; Copeland, Neal G.; Warming, Soren; Baron, Roland (The Rockefeller University Press, 2013)
      Bone homeostasis is maintained by the coupled actions of hematopoietic bone-resorbing osteoclasts (OCs) and mesenchymal bone-forming osteoblasts (OBs). Here we identify early B cell factor 1 (Ebf1) and the transcriptional ...
    • Coordinated Vascular Endothelial Growth Factor Expression and Signaling During Skeletal Myogenic Differentiation 

      Bryan, Brad A.; Walshe, T. E.; Mitchell, Dianne C.; Havumaki, Josh S.; Saint-Geniez, Magali; Maharaj, Arindel S; Maldonado, Angel E.; D'Amore, Patricia Ann (American Society for Cell Biology (ASCB), 2007)
      Angiogenesis is largely controlled by hypoxia-driven transcriptional up-regulation and secretion of vascular endothelial growth factor (VEGF) and its binding to the endothelial cell tyrosine receptor kinases, VEGFR1 and ...
    • COPI Activity Coupled with Fatty Acid Biosynthesis is Required for Viral Replication 

      Cherry, Sara; Kunte, Amit; Wang, Hui; Coyne, Carolyn; Rawson, Robert B; Perrimon, Norbert (Public Library of Science, 2006)
      During infection by diverse viral families, RNA replication occurs on the surface of virally induced cytoplasmic membranes of cellular origin. How this process is regulated, and which cellular factors are required, has ...
    • Copy Number Variation at the APOL1 Locus 

      Ruchi, Rupam; Genovese, Giulio; Lee, Jessica; Charoonratana, Victoria T.; Bernhardy, Andrea J.; Alper, Seth L.; Kopp, Jeffrey B.; Thadhani, Ravi; Friedman, David J.; Pollak, Martin R. (Public Library of Science, 2015)
      Two coding variants in the APOL1 gene (G1 and G2) explain most of the high rate of kidney disease in African Americans. APOL1-associated kidney disease risk inheritance follows an autosomal recessive pattern: The relative ...
    • Copy number variation detection in whole-genome sequencing data using the Bayesian information criterion 

      Xi, Ruibin; Hadjipanayis, Angela G.; Luquette, Lovelace J.; Kim, Tae-Min; Lee, Eunjung; Zhang, Jianhua; Johnson, Mark D.; Muzny, Donna M.; Wheeler, David A.; Gibbs, Richard A.; Kucherlapati, Raju; Park, Peter J. (National Academy of Sciences, 2011)
      DNA copy number variations (CNVs) play an important role in the pathogenesis and progression of cancer and confer susceptibility to a variety of human disorders. Array comparative genomic hybridization has been used widely ...
    • Copy number variation in bipolar disorder 

      Green, EK; Rees, E; Walters, JTR; Smith, K-G; Forty, L; Grozeva, D; Moran, JL; Sklar, P; Ripke, S; Chambert, KD; Genovese, G; McCarroll, SA; Jones, I; Jones, L; Owen, MJ; O’Donovan, MC; Craddock, N; Kirov, G (2016)
      Large (>100 kb), rare (<1% in the population) copy number variants (CNVs) have been shown to confer risk for schizophrenia (SZ), but the findings for bipolar disorder (BD) are less clear. In a new BD sample from the United ...
    • CoQ10 in progressive supranuclear palsy: A randomized, placebo-controlled, double-blind trial 

      Apetauerova, Diana; Scala, Stephanie A.; Hamill, Robert W.; Simon, David K.; Pathak, Subash; Ruthazer, Robin; Standaert, David G.; Yacoubian, Talene A. (Lippincott Williams & Wilkins, 2016)
      Objective: An investigator-initiated, multicenter, randomized, placebo-controlled, double-blind clinical trial to determine whether coenzyme Q10 (CoQ10) is safe, well tolerated, and effective in slowing functional decline ...
    • Core-Shell Nanostars for Multimodal Therapy and Imaging 

      Li, Mengyuan; Li, Lele; Zhan, Changyou; Kohane, Daniel S. (Ivyspring International Publisher, 2016)
      The coupling of diagnostic capability and effective therapy in a single multifunctional nanomedicine is desirable but remains challenging. Here, we developed multifunctional nanoparticles consisting of a gold nanostar ...
    • Corelease of acetylcholine and GABA from cholinergic forebrain neurons 

      Saunders, Arpiar; Granger, Adam J; Sabatini, Bernardo L (eLife Sciences Publications, Ltd, 2015)
      Neurotransmitter corelease is emerging as a common theme of central neuromodulatory systems. Though corelease of glutamate or GABA with acetylcholine has been reported within the cholinergic system, the full extent is ...
    • Corneal Allograft Rejection: Immunopathogenesis to Therapeutics 

      Qazi, Yureeda; Hamrah, Pedram (2013)
      Corneal transplantation is among the most successful solid organ transplants. However, despite low rejection rates of grafts in the ‘low-risk’ setting, rejection can be as high as 70% when grafted into ‘high-risk’ recipient ...
    • Corneal Antigen-Presenting Cells: Diversity, Plasticity, and Disguise The Cogan Lecture 

      Dana, Reza (Association for Research in Vision and Ophthalmology (ARVO), 2004)