Browsing HMS Scholarly Articles by Title

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    • Advances in Estrogen Receptor Biology: Prospects for Improvements in Targeted Breast Cancer Therapy 

      Shao, Wenlin; Brown, Myles Avery (BioMed Central, 2003)
      Estrogen receptor (ER) has a crucial role in normal breast development and is expressed in the most common breast cancer subtypes. Importantly, its expression is very highly predictive for response to endocrine therapy. ...

    • Advances in Multidetector CT Diagnosis of Pediatric Pulmonary Thromboembolism 

      Thacker, Paul G.; Lee, Edward Y. (The Korean Society of Radiology, 2016)
      Although pediatric pulmonary thromboembolism is historically believed to be rare with relatively little information available in the medical literature regarding its imaging evaluation, it is more common than previously ...

    • Advances in the Science, Treatment, and Prevention of the Disease of Obesity: Reflections From a Diabetes Care Editors’ Expert Forum 

      Cefalu, William T.; Bray, George A.; Home, Philip D.; Garvey, W. Timothy; Klein, Samuel; Pi-Sunyer, F. Xavier; Hu, Frank B.; Raz, Itamar; Van Gaal, Luc; Wolfe, Bruce M.; Ryan, Donna H. (American Diabetes Association, 2015)
      As obesity rates increase, so too do the risks of type 2 diabetes, cardiovascular disease, and numerous other detrimental conditions. The prevalence of obesity in U.S. adults more than doubled between 1980 and 2010, from ...

    • Advances in the Treatment of Monoclonal Gammopaties: The Emerging Role of Targeted Therapy in Plasma Cell Dyscrasias 

      Roccaro, Aldo M.; Ghobrial, Irene; Blotta, Simona; Treon, Steven P.; Malagola, Michele; Anderson, Kenneth Carl; Russo, Domenico (Dove Medical Press, 2008)
      The paradigm for the treatment of monoclonal gammopaties has dramatically changed: therapeutic options in multiple myeloma (MM) have evolved from the introduction of melphalan and prednisone in the 1960s, high-dose ...

    • Advances in the Understanding of the Pathogenesis and Epidemiology of Herpes Zoster 

      Gershon, Anne A.; Gershon, Michael D.; Breuer, Judith; Levin, Myron J.; Oaklander, Anne; Griffiths, Paul D. (Elsevier BV, 2010-05)
      The primary varicella zoster virus (VZV) infection results in chickenpox (varicella), which is transmitted via the airborne route. VZV is highly infectious, but in the USA the incidence of varicella has been reduced by ...

    • Advances in translational bioinformatics facilitate revealing the landscape of complex disease mechanisms 

      Yang, Jack Y; Dunker, A Keith; Liu, Jun S; Qin, Xiang; Arabnia, Hamid R; Yang, William; Niemierko, Andrzej; Chen, Zhongxue; Luo, Zuojie; Wang, Liangjiang; Liu, Yunlong; Xu, Dong; Deng, Youping; Tong, Weida; Yang, Mary Qu (BioMed Central, 2014)
      Advances of high-throughput technologies have rapidly produced more and more data from DNAs and RNAs to proteins, especially large volumes of genome-scale data. However, connection of the genomic information to cellular ...

    • Advances in Tumor Screening, Imaging, and Avatar Technologies for High-Grade Serous Ovarian Cancer 

      Ohman, Anders W.; Hasan, Noor; Dinulescu, Daniela M. (Frontiers Media S.A., 2014)
      The majority of high-grade serous ovarian carcinoma cases are detected in advanced stages when treatment options are limited. Surgery is less effective at eradicating the disease when it is widespread, resulting in high ...

    • Advances in understanding cartilage remodeling 

      Li, Yefu; Xu, Lin (F1000Research, 2015)
      Cartilage remodeling is currently among the most popular topics in osteoarthritis research. Remodeling includes removal of the existing cartilage and replacement by neo-cartilage. As a loss of balance between removal and ...

    • Advances in Wearable Technology and Applications in Physical Medicine and Rehabilitation 

      Bonato, Paolo (BioMed Central, 2005)
      The development of miniature sensors that can be unobtrusively attached to the body or can be part of clothing items, such as sensing elements embedded in the fabric of garments, have opened countless possibilities of ...

    • Advancing biomedical imaging 

      Weissleder, Ralph; Nahrendorf, Matthias (National Academy of Sciences, 2015)
      Imaging reveals complex structures and dynamic interactive processes, located deep inside the body, that are otherwise difficult to decipher. Numerous imaging modalities harness every last inch of the energy spectrum. ...

    • Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT 

      Deisboeck, Thomas Steve; Zhang, Le; Martin, Sean (Libertas Academica, 2007)
      Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are ...

    • Advancing medicine one research note at a time: the educational value in clinical case reports 

      Caban-Martinez, Alberto Juan; Garcia Beltran, Wilfredo F. (BioMed Central, 2012)
      A case report—a brief written note that describes unique aspects of a clinical case—provides a significant function in medicine given its rapid, succinct, and educational contributions to scientific literature and clinical ...

    • Advancing Surveillance of Chronic and Non-Communicable Disease—A Path Forward 

      Weitzman, Elissa R.; Waheed, Nadia (University of Illinois at Chicago Library, 2013)
      Objective: To characterize current and future approaches to surveillance of chronic and non-communicable diseases and establish the agenda for both methodological and condition-specific progress. Introduction: Major global ...

    • Advancing the science of ventilator-associated pneumonia surveillance 

      Klompas, Michael (BioMed Central, 2012)
      The landmark Study on the Efficacy of Nosocomial Infection Control definitively demonstrated that infection surveillance and control programs prevent hospital-acquired infections. The rise of public reporting, benchmarking, ...

    • Advantages and Limitations of Anticipating Laboratory Test Results from Regression- and Tree-Based Rules Derived from Electronic Health-Record Data 

      Mohammad, Fahim; Theisen-Toupal, Jesse C.; Arnaout, Ramy (Public Library of Science, 2014)
      Laboratory testing is the single highest-volume medical activity, making it useful to ask how well one can anticipate whether a given test result will be high, low, or within the reference interval (“normal”). We analyzed ...

    • Advantages of Percent Weight Loss as a Method of Reporting Weight Loss after Roux-en-Y Gastric Bypass 

      Hatoum, Ida J.; Kaplan, Lee M. (2012)
      Objective: Although Roux-en-Y gastric bypass (RYGB) is a generally effective treatment for severe obesity, weight loss (WL) after this operation is highly variable. Accurate predictors of outcome would thus be useful in ...

    • Adverse Drug Events in Ambulatory Care 

      Gandhi, Tejal; Weingart, Saul N.; Borus, Joshua; Seger, Andrew C.; Peterson, Josh; Burdick, Elisabeth; Seger, Diane L.; Small, Kirstin; Federico, Frank; Leape, Lucian; Bates, David (Massachusetts Medical Society, 2003-04-17)
      BACKGROUND Adverse events related to drugs occur frequently among inpatients, and many of these events are preventable. However, few data are available on adverse drug events among outpatients. We conducted a study to ...

    • Adverse Drug Events in Pediatric Outpatients 

      Kaushal, Rainu; Goldmann, Donald A.; Keohane, Carol A.; Christino, Melissa; Honour, Melissa; Hale, Andrea S.; Zigmont, Katherine; Lehmann, Lisa Soleymani; Perrin, James; Bates, David W. (Elsevier BV, 2007-09)
      Objective.-To determine rates and types of adverse drug events (ADEs) in the pediatric ambulatory setting. Methods.-A prospective cohort study at 6 office practices in the greater Boston area was conducted over 2-month ...

    • Adverse drug events in the outpatient setting: an 11-year national analysis 

      Bourgeois, Florence Tanya; Shannon, Michael W.; Valim, Clarissa; Mandl, Kenneth David (Wiley-Blackwell, 2010)
      Purpose: Adverse drug events (ADEs) are a common complication of medical care resulting in high morbidity and medical expenditure. Population level estimates of outpatient ADEs are limited. Our objective was to provide ...

    • Adverse Outcomes After Hospitalization and Delirium in Persons With Alzheimer Disease 

      Fong, Tamara G.; Jones, Richard N.; Marcantonio, Edward R.; Tommet, Douglas; Gross, Alden L.; Habtemariam, Daniel; Schmitt, Eva; Yap, Liang; Inouye, Sharon (American College of Physicians, 2012)
      BACKGROUND: Hospitalization, frequently complicated by delirium, can be a life-changing event for patients with Alzheimer disease (AD). OBJECTIVE: To determine risks for institutionalization, cognitive decline, or death ...