Browsing HMS Scholarly Articles by Title
Now showing items 471-490 of 17917
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Adverse Drug Events in Pediatric Outpatients
(Elsevier BV, 2007-09)Objective.-To determine rates and types of adverse drug events (ADEs) in the pediatric ambulatory setting. Methods.-A prospective cohort study at 6 office practices in the greater Boston area was conducted over 2-month ... -
Adverse drug events in the outpatient setting: an 11-year national analysis
(Wiley-Blackwell, 2010)Purpose: Adverse drug events (ADEs) are a common complication of medical care resulting in high morbidity and medical expenditure. Population level estimates of outpatient ADEs are limited. Our objective was to provide ... -
Adverse Outcomes After Hospitalization and Delirium in Persons With Alzheimer Disease
(American College of Physicians, 2012)BACKGROUND: Hospitalization, frequently complicated by delirium, can be a life-changing event for patients with Alzheimer disease (AD). OBJECTIVE: To determine risks for institutionalization, cognitive decline, or death ... -
Adverse Outcomes of Underuse of β-Blockers in Elderly Survivors of Acute Myocardial Infarction
(American Medical Association (AMA), 1997)Objectives. —To study determinants and adverse outcomes (mortality and rehospitalization) of β-blocker underuse in elderly patients with myocardial infarction; and whether the relative risks (RRs) of survival associated ... -
Afatinib versus methotrexate in older patients with second-line recurrent and/or metastatic head and neck squamous cell carcinoma: subgroup analysis of the LUX-Head & Neck 1 trial†
(Oxford University Press, 2016)Background: In the phase III LUX-Head & Neck 1 (LHN1) trial, afatinib significantly improved progression-free survival (PFS) versus methotrexate in recurrent and/or metastatic (R/M) head and neck squamous cell carcinoma ... -
Affective and Neural Reactivity to Criticism in Individuals High and Low on Perceived Criticism
(Public Library of Science, 2012)People who have remitted from depression are at increased risk for relapse if they rate their relatives as being critical of them on a simple self-report measure of Perceived Criticism (PC). To explore neural mechanisms ... -
Affinity flow fractionation of cells via transient interactions with asymmetric molecular patterns
(Nature Publishing Group, 2013)Flow fractionation of cells using physical fields to achieve lateral displacement finds wide applications, but its extension to surface molecule-specific separation requires labeling. Here we demonstrate affinity flow ... -
Affinity Inequality among Serum Antibodies That Originate in Lymphoid Germinal Centers
(Public Library of Science, 2015)Upon natural infection with pathogens or vaccination, antibodies are produced by a process called affinity maturation. As affinity maturation ensues, average affinity values between an antibody and ligand increase with ... -
Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains
(National Academy of Sciences, 2014)Rapidly evolving pathogens, such as human immunodeficiency and influenza viruses, escape immune defenses provided by most vaccine-induced antibodies. Proposed strategies to elicit broadly neutralizing antibodies require a ... -
An affinity-based scoring scheme for predicting DNA-binding activities of modularly assembled zinc-finger proteins
(Oxford University Press, 2009)Zinc-finger proteins (ZFPs) have long been recognized for their potential to manipulate genetic information because they can be engineered to bind novel DNA targets. Individual zinc-finger domains (ZFDs) bind specific DNA ... -
An affinity-structure database of helix-turn-helix: DNA complexes with a universal coordinate system
(BioMed Central, 2015)Background: Molecular interactions between proteins and DNA molecules underlie many cellular processes, including transcriptional regulation, chromosome replication, and nucleosome positioning. Computational analyses of ... -
Affordability of health care under publicly subsidized insurance after Massachusetts health care reform: a qualitative study of safety net patients
(BioMed Central, 2015)Introduction: The Affordable Care Act (ACA) and the 2006 Massachusetts (MA) health reform law, on which the ACA was based, aimed to improve the affordability of care largely by expanding publicly sponsored insurances. Both ... -
African Ancestry and Its Correlation to Type 2 Diabetes in African Americans: A Genetic Admixture Analysis in Three U.S. Population Cohorts
(Public Library of Science, 2012)The risk of type 2 diabetes is approximately 2-fold higher in African Americans than in European Americans even after adjusting for known environmental risk factors, including socioeconomic status (SES), suggesting that ... -
After abduction: exploring access to reintegration programs and mental health status among young female abductees in Northern Uganda
(BioMed Central, 2014)Background: Reintegration programs are commonly offered to former combatants and abductees to acquire civilian status and support services to reintegrate into post-conflict society. Among a group of young female abductees ... -
After Adoption: Sustaining the Innovation A Case Study of Disseminating the Hospital Elder Life Program
(Wiley-Blackwell, 2005)OBJECTIVES: To examine key factors that influence sustainability in the diffusion of the Hospital Elder Life Program (HELP) as an example of an evidence-based, multifaceted, innovative program to improve care for hospitalized ... -
Age and Gender Moderate the Impact of Early Palliative Care in Metastatic Non-Small Cell Lung Cancer
(AlphaMed Press, 2016)Background. Studies demonstrate that early palliative care (EPC) improves advanced cancer patients’ quality of life (QOL) and mood. However, it remains unclear whether the role of palliative care differs based upon patients’ ... -
Age at Developmental Cortical Injury Differentially Alters Corpus Callosum Volume in the Rat
(BioMed Central, 2007)Background: Freezing lesions to developing rat cortex induced between postnatal day (P) one and three (P1 – 3) lead to malformations similar to human microgyria, and further correspond to reductions in brain weight and ... -
Age cutoff for Epstein-Barr virus-positive diffuse large B-cell lymphoma–is it necessary?
(Impact Journals LLC, 2015)Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly (EBV+ DLBCL-e) is a molecularly distinct variant of DLBCL, characterized by a monoclonal B-cell proliferation that occurs in patients >50 years of ... -
Age Differences in the Required Coefficient of Friction During Level Walking Do Not Exist When Experimentally-Controlling Speed and Step Length
(Human Kinetics, 2014)The effects of gait speed and step length on the required coefficient of friction (COF) confounds the investigation of age-related differences in required COF. The goals of this study were to investigate whether age ... -
Age Is the Only Predictor of Poor Bowel Preparation in the Hospitalized Patient
(Hindawi Publishing Corporation, 2016)We examine the impact of key variables on the likelihood of inpatient poor bowel preparation for colonoscopy. Records of inpatients that underwent colonoscopy at our institution between January 2010 and December 2011 were ...