Browsing HMS Scholarly Articles by Title
Now showing items 4757-4776 of 17922
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A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth
(Landes Bioscience, 2014)Neurofibromatosis type 1 (NF1) is caused by loss of a negative regulator of Ras oncoproteins. Unknown genetic modifiers have been implicated in NF1’s characteristic variability. Drosophila melanogaster dNf1 phenotypes ... -
Drosophila selenophosphate synthetase 1 regulates vitamin B6 metabolism: prediction and confirmation
(BMC, 2011)Background: There are two selenophosphate synthetases (SPSs) in higher eukaryotes, SPS1 and SPS2. Of these two isotypes, only SPS2 catalyzes selenophosphate synthesis. Although SPS1 does not contain selenophosphate synthesis ... -
The Drosophila Spitz Gene Encodes a Putative EGF-Like Growth Factor Involved in Dorsal-Ventral Axis Formation and Neurogenesis
(Cold Spring Harbor Laboratory, 1992-08-01)We describe the molecular characterization of the Drosophila gene spitz (spi), which encodes a putative 26-kD, EGF-like transmembrane protein that is structurally similar to TGF-alpha. Temporal and spatial expression ... -
The Drosophila Sugarless Gene Modulates Wingless Signaling and Encodes an Enzyme Involved in Polysaccharide Biosynthesis
(The Company of Biologists, 1997-09-15)We have identified and characterized a Drosophila gene, which we have named sugarless, that encodes a homologue of vertebrate UDP-glucose dehydrogenase. This enzyme is essential for the biosynthesis of various proteoglycans, ... -
Drosophila Terminal Structure Development Is Regulated by the Compensatory Activities of Positive and Negative Phosphotyrosine Signaling Sites on the Torso RTK.
(Cold Spring Harbor Laboratory, 1996-03-01)Specification of cell fates in the nonsegmented terminal regions of developing Drosophila embryos is under the control of a signal transduction pathway mediated by the receptor tyrosine kinase Torso (Tor). Here, we identify ... -
Drosophila Unpaired Encodes a Secreted Protein That Activates the JAK Signaling Pathway
(Cold Spring Harbor Laboratory, 1998-10-15)In vertebrates, many cytokines and growth factors have been identified as activators of the JAK/STAT signaling pathway. In Drosophila, JAK and STAT molecules have been isolated, but no ligands or receptors capable of ... -
Drug addiction mutations unveil a repressive methylation ceiling in EZH2-mutant lymphoma
(Research Square Platform LLC, 2022-07-22)Drug addiction, a phenomenon where cancer cells paradoxically depend on continuous drug treatment for survival, has uncovered cell signaling mechanisms and cancer co-dependencies. Here, we discover mutations that confer ... -
Drug Adverse Event Detection in Health Plan Data Using the Gamma Poisson Shrinker and Comparison to the Tree-based Scan Statistic
(MDPI, 2013)Background: Drug adverse event (AE) signal detection using the Gamma Poisson Shrinker (GPS) is commonly applied in spontaneous reporting. AE signal detection using large observational health plan databases can expand ... -
The Drug Data to Knowledge Pipeline: Large-Scale Claims Data Classification for Pharmacologic Insight
(American Medical Informatics Association, 2016)In biomedical informatics, assigning drug codes to categories is a common step in the analysis pipeline. Unfortunately, incomplete mappings are the norm rather than the exception with coverage values less than 85% not ... -
Drug Delivery Approaches for the Treatment of Cervical Cancer
(MDPI, 2016)Cervical cancer is a highly prevalent cancer that affects women around the world. With the availability of new technologies, researchers have increased their efforts to develop new drug delivery systems in cervical cancer ... -
A Drug Delivery System for Administration of Anti–TNF-α Antibody
(The Association for Research in Vision and Ophthalmology, 2016)Purpose To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti–TNF-α antibody administration. Methods: A DDS was fabricated using inverse template ... -
Drug delivery systems in urology—getting “smarter”
(Elsevier BV, 2006)Urology holds the most enviable position in the medical firmament. Unique among specialties in bringing the surgeon in contact with humans throughout the spectrum of human life—from newborn to geriatric patients—urologists ... -
Drug delivery, biomaterials and nanomedicine: an interview with Daniel S Kohane
(Future Science Ltd, 2016)Daniel Kohane speaks to Francesca Lake, Managing Editor: Obtaining his MD and PhD in Physiology from Boston University (MA, USA), Dan Kohane went on to complete residencies in Pediatrics at Boston Children’s Hospital (MA, ... -
Drug Induced Liver Injury: Review with a Focus on Genetic Factors, Tissue Diagnosis, and Treatment Options
(XIA & HE Publishing Ltd, 2015)Drug-induced liver injury (DILI) is a rare but potentially life threatening adverse drug reaction. DILI may mimic any morphologic characteristic of acute or chronic liver disease, and the histopathologic features of DILI ... -
Drug Rash with Eosinophilia and Systemic Symptoms: Two Emergency Department Cases
(University of California, Irvine, 2011)Drug rash with eosinophilia and systemic symptoms (DRESS) is a rare, severe adverse drug event that appears with a generalized rash, fevers, and dysfunction of 1 or more organ systems. We describe 2 patients (1 adult and ... -
Drug Resistance in Cancer: An Overview
(MDPI, 2014)Cancers have the ability to develop resistance to traditional therapies, and the increasing prevalence of these drug resistant cancers necessitates further research and treatment development. This paper outlines the current ... -
Drug Resistance Mutations for Surveillance of Transmitted HIV-1 Drug-Resistance: 2009 Update
(Public Library of Science, 2009)Programs that monitor local, national, and regional levels of transmitted HIV-1 drug resistance inform treatment guidelines and provide feedback on the success of HIV-1 treatment and prevention programs. To accurately ... -
Drug Safety in the Digital Age
(New England Journal of Medicine (NEJM/MMS), 2014) -
Drug Screening Boosted by Hyperpolarized Long-Lived States in NMR
(WILEY-VCH Verlag, 2014)Transverse and longitudinal relaxation times (T1ρ and T1) have been widely exploited in NMR to probe the binding of ligands and putative drugs to target proteins. We have shown recently that long-lived states (LLS) can be ... -
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval
(2013)Variability in response to drug use is common and heritable, suggesting that genome-wide pharmacogenomics studies may help explain the “missing heritability” of complex traits. Here, we describe four independent analyses ...